Erschienen in:
01.11.2009 | Original Article
Vitamin D status and falls, frailty, and fractures among postmenopausal Japanese women living in Hawaii
verfasst von:
P. Pramyothin, S. Techasurungkul, J. Lin, H. Wang, A. Shah, P. D. Ross, R. Puapong, R. D. Wasnich
Erschienen in:
Osteoporosis International
|
Ausgabe 11/2009
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Abstract
Summary
Vitamin D status and its relationship to physical performance, falls, and fractures in 495 postmenopausal women of Japanese ancestry in Hawaii were investigated. The mean 25-hydroxyvitamin D (25-OHD) was 31.94 ng/mL. No significant association of 25-OHD was demonstrated with most outcomes, possibly due to higher 25-OHD levels in this population.
Introduction
In this study, we investigated vitamin D status and its relationship to physical performance, muscle strength, falls, and fractures in postmenopausal Japanese females living in Hawaii.
Methods
Of 510 community-dwelling women who participated in the eighth examination of the Hawaii Osteoporosis Study, 495 were included in these analyses. Multivariate regression models were used to evaluate the relationship of 25-OHD (D3 and total) to eight performance-based measurements, 12 activities of daily living (ADLs), and muscle strength (grip, triceps, and quadriceps). Logistic regression analyses were performed to evaluate the relationship of 25-OHD to falls, vertebral fractures, and non-vertebral fractures.
Results
The mean total 25-OHD was 31.94 ± 9.46 ng/mL; 44% of subjects had values <30 ng/mL, while none had values <10–12 ng/mL. There was little evidence of seasonal variation. Among performance-based measures, ADLs, and strength tests, only quadriceps strength was significantly associated with total 25-OHD (p = 0.0063) and 25-OHD3 (p = 0.0001). No significant association of 25-OHD was found with vertebral or non-vertebral fractures, or incidence of one or more falls.
Conclusions
Lack of serum 25-OHD relationship with falls and fractures or most physical performance measures in this study may be related to the low prevalence of very low 25-OHD levels in this population.