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Erschienen in: Osteoporosis International 11/2009

01.11.2009 | Original Article

Vitamin D status and falls, frailty, and fractures among postmenopausal Japanese women living in Hawaii

verfasst von: P. Pramyothin, S. Techasurungkul, J. Lin, H. Wang, A. Shah, P. D. Ross, R. Puapong, R. D. Wasnich

Erschienen in: Osteoporosis International | Ausgabe 11/2009

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Abstract

Summary

Vitamin D status and its relationship to physical performance, falls, and fractures in 495 postmenopausal women of Japanese ancestry in Hawaii were investigated. The mean 25-hydroxyvitamin D (25-OHD) was 31.94 ng/mL. No significant association of 25-OHD was demonstrated with most outcomes, possibly due to higher 25-OHD levels in this population.

Introduction

In this study, we investigated vitamin D status and its relationship to physical performance, muscle strength, falls, and fractures in postmenopausal Japanese females living in Hawaii.

Methods

Of 510 community-dwelling women who participated in the eighth examination of the Hawaii Osteoporosis Study, 495 were included in these analyses. Multivariate regression models were used to evaluate the relationship of 25-OHD (D3 and total) to eight performance-based measurements, 12 activities of daily living (ADLs), and muscle strength (grip, triceps, and quadriceps). Logistic regression analyses were performed to evaluate the relationship of 25-OHD to falls, vertebral fractures, and non-vertebral fractures.

Results

The mean total 25-OHD was 31.94 ± 9.46 ng/mL; 44% of subjects had values <30 ng/mL, while none had values <10–12 ng/mL. There was little evidence of seasonal variation. Among performance-based measures, ADLs, and strength tests, only quadriceps strength was significantly associated with total 25-OHD (p = 0.0063) and 25-OHD3 (p = 0.0001). No significant association of 25-OHD was found with vertebral or non-vertebral fractures, or incidence of one or more falls.

Conclusions

Lack of serum 25-OHD relationship with falls and fractures or most physical performance measures in this study may be related to the low prevalence of very low 25-OHD levels in this population.
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Metadaten
Titel
Vitamin D status and falls, frailty, and fractures among postmenopausal Japanese women living in Hawaii
verfasst von
P. Pramyothin
S. Techasurungkul
J. Lin
H. Wang
A. Shah
P. D. Ross
R. Puapong
R. D. Wasnich
Publikationsdatum
01.11.2009
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 11/2009
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-009-0910-5

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