nach oben

Osteoporosis International

Erschienen in:

01.10.2010 | Original Article

Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men

verfasst von: S. Beer, C. H. Saely, G. Hoefle, P. Rein, A. Vonbank, J. Breuss, B. Gaensbacher, A. Muendlein, H. Drexel

Erschienen in: Osteoporosis International | Ausgabe 10/2010

Einloggen, um Zugang zu erhalten

Abstract

Summary

This study for the first time investigates the association of bone mineral density (BMD) with angiographically determined coronary atherosclerosis in men. Our data show that the prevalence of low BMD is very high in men undergoing coronary angiography. However, neither osteopenia nor osteoporosis is associated with an increased prevalence of angiographically determined coronary atherosclerosis.

Introduction

The association of low BMD with angiographically determined coronary atherosclerosis in men is unknown.

Methods

We enrolled 623 consecutive men undergoing coronary angiography for the evaluation of established or suspected coronary artery disease (CAD). BMD was assessed by dual X-ray absorptiometry. CAD was diagnosed in the presence of any coronary artery lumen narrowing at angiography; coronary stenoses with lumen narrowing ≥50% were considered significant.

Results

From the total study cohort (mean age of 64 ± 11 years), 207 patients (33.2%) had osteopenia and 65 (10.4%) had osteoporosis; at angiography, CAD was diagnosed in 558 patients (89.6%) and 403 (64.7%) had significant coronary stenoses. In multivariate logistic regression analysis neither osteopenia nor osteoporosis was associated with an increased prevalence of CAD (adjusted odds ratios (ORs) = 0.71 [95% confidence interval 0.40–1.23]; p = 0.222 and 1.03 [0.38–2.80]; p = 0.955, respectively) or with significant coronary stenoses (OR 0.74 [0.52–1.07], p = 0.112 and 0.72 [0.41–1.26]; p = 0.251, respectively). Also, as a continuous variable, BMD was not associated with angiographically diagnosed CAD.

Conclusions

The prevalence of low BMD is very high in men undergoing coronary angiography. However, low BMD is not associated with angiographically determined coronary atherosclerosis in men.

Epstein FH (1996) Cardiovascular disease epidemiology: a journey from the past into the future. Circulation 93:1755–1764PubMed

Cooper C, Atkinson EJ, Jacobsen SJ et al (1993) Population-based study of survival after osteoporotic fractures. Am J Epidemiol 137:1001–1005PubMed

Keene GS, Parker MJ, Pryor GA (1993) Mortality and morbidity after hip fractures. BMJ 307:1248–1250CrossRefPubMed

Burge R, Dawson-Hughes B, Solomon DH et al (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res 22:465–475CrossRefPubMed

Dolan P, Torgerson DJ (1998) The cost of treating osteoporotic fractures in the United Kingdom female population. Osteoporos Int 8:611–617CrossRefPubMed

Cooper C (1997) The crippling consequences of fractures and their impact on quality of life. Am J Med 103:12S–17SCrossRefPubMed

Peterson AM, McGhan WF (2005) Pharmacoeconomic impact of non-compliance with statins. Pharmacoeconomics 23:13–25CrossRefPubMed

van Jaarsveld CH, Sanderman R, Ranchor AV et al (2002) Gender-specific changes in quality of life following cardiovascular disease: a prospective study. J Clin Epidemiol 55:1105–1112CrossRefPubMed

Tanko LB, Bagger YZ, Christiansen C (2003) Low bone mineral density in the hip as a marker of advanced atherosclerosis in elderly women. Calcif Tissue Int 73:15–20CrossRefPubMed

10.

Barengolts EI, Berman M, Kukreja SC et al (1998) Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int 62:209–213CrossRefPubMed

11.

Kiel DP, Kauppila LI, Cupples LA et al (2001) Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int 68:271–276CrossRefPubMed

12.

Hak AE, Pols HA, van Hemert AM et al (2000) Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler Thromb Vasc Biol 20:1926–1931PubMed

13.

Hofbauer LC, Brueck CC, Shanahan CM et al (2007) Vascular calcification and osteoporosis—from clinical observation towards molecular understanding. Osteoporos Int 18:251–259CrossRefPubMed

14.

Doherty TM, Detrano RC (1994) Coronary arterial calcification as an active process: a new perspective on an old problem. Calcif Tissue Int 54:224–230CrossRefPubMed

15.

Schmid K, McSharry WO, Pameijer CH, Binette JP (1980) Chemical and physicochemical studies on the mineral deposits of the human atherosclerotic aorta. Atherosclerosis 37:199–210CrossRefPubMed

16.

Shanahan CM, Cary NR, Metcalfe JC, Weissberg PL (1994) High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J Clin Invest 93:2393–2402CrossRefPubMed

17.

Bostrom K, Watson KE, Horn S et al (1993) Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest 91:1800–1809CrossRefPubMed

18.

Giachelli CM, Bae N, Almeida M et al (1993) Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J Clin Invest 92:1686–1696CrossRefPubMed

19.

Dhore CR, Cleutjens JP, Lutgens E et al (2001) Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 21:1998–2003CrossRefPubMed

20.

Von der RP, Hansen MA, Hassager C (1999) The association between low bone mass at the menopause and cardiovascular mortality. Am J Med 106:273–278CrossRef

21.

Samelson EJ, Kiel DP, Broe KE et al (2004) Metacarpal cortical area and risk of coronary heart disease: the Framingham Study. Am J Epidemiol 159:589–595CrossRefPubMed

22.

Trivedi DP, Khaw KT (2001) Bone mineral density at the hip predicts mortality in elderly men. Osteoporos Int 12:259–265CrossRefPubMed

23.

Tanko LB, Christiansen C, Cox DA et al (2005) Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res 20:1912–1920CrossRefPubMed

24.

Fuster V, Badimon L, Badimon JJ, Chesebro JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 326:310–318CrossRefPubMed

25.

Fuster V, Badimon L, Badimon JJ, Chesebro JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med 326:242–250CrossRefPubMed

26.

Marcovitz PA, Tran HH, Franklin BA et al (2005) Usefulness of bone mineral density to predict significant coronary artery disease. Am J Cardiol 96:1059–1063CrossRefPubMed

27.

Tekin GO, Kekilli E, Yagmur J et al (2008) Evaluation of cardiovascular risk factors and bone mineral density in post menopausal women undergoing coronary angiography. Int J Cardiol 131:66–69CrossRefPubMed

28.

Sytkowski PA, D’Agostino RB, Belanger A, Kannel WB (1996) Sex and time trends in cardiovascular disease incidence and mortality: the Framingham Heart Study, 1950–1989. Am J Epidemiol 143:338–350PubMed

29.

Chobanian AV, Bakris GL, Black HR et al (2003) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289:2560–2572CrossRefPubMed

30.

Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539–553CrossRefPubMed

31.

Saely CH, Koch L, Schmid F et al (2006) Lipoprotein(a), type 2 diabetes and vascular risk in coronary patients. Eur J Clin Invest 36:91–97CrossRefPubMed

32.

Kanis JA, Melton LJ III, Christiansen C et al (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137–1141CrossRefPubMed

33.

Drexel H, Aczel S, Marte T et al (2005) Is atherosclerosis in diabetes and impaired fasting glucose driven by elevated LDL cholesterol or by decreased HDL cholesterol? Diabetes Care 28:101–107CrossRefPubMed

34.

Muendlein A, Saely CH, Marte T et al (2008) Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3–482 C>T polymorphisms on their association with coronary artery disease. Atherosclerosis 199:179–186CrossRefPubMed

35.

Marte T, Saely CH, Schmid F et al (2009) Effectiveness of atrial fibrillation as an independent predictor of death and coronary events in patients having coronary angiography. Am J Cardiol 103:36–40CrossRefPubMed

36.

Saely CH, Drexel H, Sourij H et al (2008) Key role of postchallenge hyperglycemia for the presence and extent of coronary atherosclerosis: an angiographic study. Atherosclerosis 199:317–322CrossRefPubMed

37.

Drexel H, Amann FW, Rentsch K et al (1992) Relation of the level of high-density lipoprotein subfractions to the presence and extent of coronary artery disease. Am J Cardiol 70:436–440CrossRefPubMed

38.

Drexel H, Amann FW, Beran J et al (1994) Plasma triglycerides and three lipoprotein cholesterol fractions are independent predictors of the extent of coronary atherosclerosis. Circulation 90:2230–2235PubMed

39.

Gluer CC, Eastell R, Reid DM et al (2004) Association of five quantitative ultrasound devices and bone densitometry with osteoporotic vertebral fractures in a population-based sample: the OPUS Study. J Bone Miner Res 19:782–793CrossRefPubMed

40.

Haussler B, Gothe H, Gol D et al (2007) Epidemiology, treatment and costs of osteoporosis in Germany—the BoneEVA Study. Osteoporos Int 18:77–84CrossRefPubMed

41.

Ebeling PR (2008) Clinical practice. Osteoporosis in men. N Engl J Med 358:1474–1482CrossRefPubMed

42.

Hoefle G, Saely CH, Aczel S et al (2005) Impact of total and central obesity on vascular mortality in patients undergoing coronary angiography. Int J Obes (Lond) 29:785–791CrossRef

43.

Saely CH, Koch L, Schmid F et al (2006) Adult Treatment Panel III 2001 but not International Diabetes Federation 2005 criteria of the metabolic syndrome predict clinical cardiovascular events in subjects who underwent coronary angiography. Diabetes Care 29:901–907CrossRefPubMed

44.

Varma R, Aronow WS, Basis Y et al (2008) Relation of bone mineral density to frequency of coronary heart disease. Am J Cardiol 101:1103–1104CrossRefPubMed

45.

Saely CH, Vonbank A, Rein P et al (2008) Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis. Clin Chim Acta 397:82–86CrossRefPubMed

Titel: Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men
verfasst von: S. Beer
C. H. Saely
G. Hoefle
P. Rein
A. Vonbank
J. Breuss
B. Gaensbacher
A. Muendlein
H. Drexel
Publikationsdatum: 01.10.2010
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 10/2010
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-1103-y

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen.
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

18.04.2024 | Wirbelsäulenmetastase | Nachrichten

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men

Abstract

Summary

Introduction

Methods

Results

Conclusions

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Brustkrebs in der Vorgeschichte macht Gelenkersatz komplikationsträchtiger

Zwei neue Alternativen zu TNF-Inhibitoren bei axSpA

Update Orthopädie und Unfallchirurgie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Summary

Introduction

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2010

Novel ultrasonic bone densitometry based on two longitudinal waves: significant correlation with pQCT measurement values and age-related changes in trabecular bone density, cortical thickness, and elastic modulus of trabecular bone in a normal Japanese population

Outdoor air pollution, bone density and self-reported forearm fracture: the Oslo Health Study

“Evidence-based” or “logic-based” medicine?

Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial

A systematic review of interventions by healthcare professionals on community-dwelling postmenopausal women with osteoporosis

Cross-sectional geometry of weight-bearing tibia in female athletes subjected to different exercise loadings

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Brustkrebs in der Vorgeschichte macht Gelenkersatz komplikationsträchtiger

Zwei neue Alternativen zu TNF-Inhibitoren bei axSpA

Update Orthopädie und Unfallchirurgie