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Erschienen in: Osteoporosis International 8/2011

01.08.2011 | Original Article

Fall mechanisms, bone strength, and hip fractures in elderly men and women in Taiwan

verfasst von: H.-F. Hwang, H.-D. Lee, H.-H. Huang, C.-Y. Chen, M.-R. Lin

Erschienen in: Osteoporosis International | Ausgabe 8/2011

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Abstract

Summary

Three modifiable factors of fall direction, poor bone strength, and depression were associated with an increased risk of hip fractures for elderly men and women; fall direction was a much stronger predictor than the other two. When a fall occurs, changing fall direction may be most effective to prevent hip fractures.

Introduction

A matched case-control study was conducted to identify risk factors for hip fractures in elderly men and women in Taiwan.

Methods

Cases were defined as persons who visited the emergency room due to a fall and were diagnosed with a first hip fracture. For each case, a control was matched by gender and time of falling, selected from persons who sought care at the same emergency room due to a fall resulting in injury other than a hip fracture. In total, 85 paired men and 221 paired women were included.

Results

For men, backward, straight-down, and sideways falls were associated with 10.8-, 13.6-, and 15.2-fold increased risks of hip fractures, respectively, compared with forward falls. Poor bone strength and depression were associated with 2.27- and 2.85-fold increased risks of hip fractures, respectively, while dependence in ≥3 activities of daily living was associated with a fivefold lower risk. For women, compared with forward falls, backward, straight-down, and sideways falls were associated with 10.2-, 9.86-, and 12.8-fold increased risks of hip fractures, respectively. Living in a rented house, poor bone strength, depression, and use of antidiabetics were associated with 1.65-, 2.78-, 1.89-, and 1.92-fold increased risks of hip fractures, respectively. Hormone replacement therapy was associated with a fivefold lower risk of hip fractures.

Conclusions

While bone strength and depression can be risk factors for hip fractures in elderly people, the direction of the fall was the strongest predictor. Some risk factors differed between elderly men and women.
Literatur
1.
Zurück zum Zitat Cummings SR, Kelsey JL, Nevitt MC, O’Dowd KJ (1985) Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 7:178–208PubMed Cummings SR, Kelsey JL, Nevitt MC, O’Dowd KJ (1985) Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 7:178–208PubMed
2.
Zurück zum Zitat Kannus P, Parkkari J, Koskinen S et al (1999) Fall-induced injuries and deaths among older adults. JAMA 281(20):1895–1899PubMedCrossRef Kannus P, Parkkari J, Koskinen S et al (1999) Fall-induced injuries and deaths among older adults. JAMA 281(20):1895–1899PubMedCrossRef
3.
Zurück zum Zitat Grisso JA, Kelsey JL, Strom BL et al (1991) Risk factors for falls as a cause of hip fracture in women. The Northeast hip fracture study group. N Engl J Med 324(19):1326–1331PubMedCrossRef Grisso JA, Kelsey JL, Strom BL et al (1991) Risk factors for falls as a cause of hip fracture in women. The Northeast hip fracture study group. N Engl J Med 324(19):1326–1331PubMedCrossRef
4.
Zurück zum Zitat Bentler SE, Liu L, Obrizan M et al (2009) The aftermath of hip fracture: discharge placement, functional status change and mortality. Am J Epidemiol 170:1290–1299PubMedCrossRef Bentler SE, Liu L, Obrizan M et al (2009) The aftermath of hip fracture: discharge placement, functional status change and mortality. Am J Epidemiol 170:1290–1299PubMedCrossRef
5.
Zurück zum Zitat Magaziner J, Fredman L, Hawkes W et al (2003) Changes in functional status attributable to hip fracture: a comparison of hip fracture patients to community-dwelling aged. Am J Epidemiol 157(11):1023–1031PubMedCrossRef Magaziner J, Fredman L, Hawkes W et al (2003) Changes in functional status attributable to hip fracture: a comparison of hip fracture patients to community-dwelling aged. Am J Epidemiol 157(11):1023–1031PubMedCrossRef
6.
Zurück zum Zitat Resnick NM, Greenspan SL (1989) ‘Senile’ osteoporosis reconsidered. JAMA 17 261(7):1025–1029CrossRef Resnick NM, Greenspan SL (1989) ‘Senile’ osteoporosis reconsidered. JAMA 17 261(7):1025–1029CrossRef
7.
Zurück zum Zitat Koot VC, Peeters PH, de Jong JR, Clevers GJ, van der Werken C (2000) Functional results after treatment of hip fracture: a multicentre, prospective study in 215 patients. Eur J Surg 166:480–485PubMedCrossRef Koot VC, Peeters PH, de Jong JR, Clevers GJ, van der Werken C (2000) Functional results after treatment of hip fracture: a multicentre, prospective study in 215 patients. Eur J Surg 166:480–485PubMedCrossRef
8.
Zurück zum Zitat Cummings SR, Nevitt MC, Browner WS et al (1995) Risk factors for hip fracture in white women. Study of osteoporotic fractures research group. N Engl J Med 332(12):767–773PubMedCrossRef Cummings SR, Nevitt MC, Browner WS et al (1995) Risk factors for hip fracture in white women. Study of osteoporotic fractures research group. N Engl J Med 332(12):767–773PubMedCrossRef
9.
Zurück zum Zitat Kanis J, Johnell O, Gullberg B et al (1999) Risk factors for hip fracture in men from southern Europe: the MEDOS study. Mediterranean osteoporosis study. Osteoporos Int 9(1):45–54PubMedCrossRef Kanis J, Johnell O, Gullberg B et al (1999) Risk factors for hip fracture in men from southern Europe: the MEDOS study. Mediterranean osteoporosis study. Osteoporos Int 9(1):45–54PubMedCrossRef
10.
Zurück zum Zitat Lan TY, Hou SM, Chen CY et al (2010) Risk factors for hip fracture in older adults: a case-control study in Taiwan. Osteoporos Int 21(5):773–784PubMedCrossRef Lan TY, Hou SM, Chen CY et al (2010) Risk factors for hip fracture in older adults: a case-control study in Taiwan. Osteoporos Int 21(5):773–784PubMedCrossRef
11.
Zurück zum Zitat Stone KL, Seeley DG, Lui LY et al (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the study of osteoporotic fractures. J Bone Miner Res 18:1947–1954PubMedCrossRef Stone KL, Seeley DG, Lui LY et al (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the study of osteoporotic fractures. J Bone Miner Res 18:1947–1954PubMedCrossRef
12.
Zurück zum Zitat Kannus P, Sievänen H, Palvanen M, Järvinen T, Parkkari J (2005) Prevention of falls and consequent injuries in elderly people. Lancet 366(9500):1885–1893PubMedCrossRef Kannus P, Sievänen H, Palvanen M, Järvinen T, Parkkari J (2005) Prevention of falls and consequent injuries in elderly people. Lancet 366(9500):1885–1893PubMedCrossRef
13.
Zurück zum Zitat Hayes WC, Myers ER, Robinovitch SN, van den Kroonenberg AJ, Courtney AC, McMahon TA (1996) Etiology and prevention of age-related hip fractures. Bone 18(Suppl 1):77 S–86 S Hayes WC, Myers ER, Robinovitch SN, van den Kroonenberg AJ, Courtney AC, McMahon TA (1996) Etiology and prevention of age-related hip fractures. Bone 18(Suppl 1):77 S–86 S
14.
Zurück zum Zitat Greenspan SL, Myers ER, Maitland LA, Resnick NM, Hayes WC (1994) Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA 271(2):128–133PubMedCrossRef Greenspan SL, Myers ER, Maitland LA, Resnick NM, Hayes WC (1994) Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA 271(2):128–133PubMedCrossRef
15.
Zurück zum Zitat Järvinen TL, Sievänen H, Khan KM, Heinonen A, Kannus P (2008) Shifting the focus in fracture prevention from osteoporosis to falls. BMJ 336(7636):124–126PubMedCrossRef Järvinen TL, Sievänen H, Khan KM, Heinonen A, Kannus P (2008) Shifting the focus in fracture prevention from osteoporosis to falls. BMJ 336(7636):124–126PubMedCrossRef
16.
Zurück zum Zitat Cummings SR, Nevitt MC (1989) A hypothesis: the causes of hip fractures. J Gerontol 44(4):M107–M111PubMed Cummings SR, Nevitt MC (1989) A hypothesis: the causes of hip fractures. J Gerontol 44(4):M107–M111PubMed
17.
Zurück zum Zitat Hayes WC, Myers ER, Morris JN, Gerhart TN, Yett HS, Lipsitz LA (1993) Impact near the hip dominates fracture risk in elderly nursing home residents who fall. Calcif Tissue Int 52(3):192–198PubMedCrossRef Hayes WC, Myers ER, Morris JN, Gerhart TN, Yett HS, Lipsitz LA (1993) Impact near the hip dominates fracture risk in elderly nursing home residents who fall. Calcif Tissue Int 52(3):192–198PubMedCrossRef
18.
Zurück zum Zitat Grisso JA, Kelsey JL, Strom BL et al (1994) Risk factors for hip fracture in black women. N Engl J Med 330:1555–1559PubMedCrossRef Grisso JA, Kelsey JL, Strom BL et al (1994) Risk factors for hip fracture in black women. N Engl J Med 330:1555–1559PubMedCrossRef
19.
Zurück zum Zitat Grisso JA, Kelsey JL, O’Brien LA et al (1997) Risk factors for hip fracture in men. Am J Epidemiol 145:786–793PubMed Grisso JA, Kelsey JL, O’Brien LA et al (1997) Risk factors for hip fracture in men. Am J Epidemiol 145:786–793PubMed
20.
Zurück zum Zitat Cumming RG, Klineberg R (1994) Case-control study of risk factors for hip fractures in the elderly. Am J Epidemiol 139:493–503PubMed Cumming RG, Klineberg R (1994) Case-control study of risk factors for hip fractures in the elderly. Am J Epidemiol 139:493–503PubMed
21.
Zurück zum Zitat Lau EM, Lee JK, Suriwongpaisal P et al (2001) The incidence of hip fracture in four Asian countries: the Asian Osteoporosis Study (AOS). Osteoporos Int 12(3):239–243PubMedCrossRef Lau EM, Lee JK, Suriwongpaisal P et al (2001) The incidence of hip fracture in four Asian countries: the Asian Osteoporosis Study (AOS). Osteoporos Int 12(3):239–243PubMedCrossRef
22.
Zurück zum Zitat Chie WC, Yang RS, Liu JP, Tsai KS (2004) High incidence rate of hip fracture in Taiwan: estimated from a nationwide health insurance database. Osteoporos Int 15(12):998–1002PubMedCrossRef Chie WC, Yang RS, Liu JP, Tsai KS (2004) High incidence rate of hip fracture in Taiwan: estimated from a nationwide health insurance database. Osteoporos Int 15(12):998–1002PubMedCrossRef
23.
Zurück zum Zitat Lamb SW, Jørstad-Stein EC, Hauer K, Becker C (2005) Prevention of falls network Europe and outcomes consensus group. Development of a common outcome data set for fall injury prevention trials: the prevention of falls network Europe consensus. J Am Geriatr Soc 53(9):1618–1622PubMedCrossRef Lamb SW, Jørstad-Stein EC, Hauer K, Becker C (2005) Prevention of falls network Europe and outcomes consensus group. Development of a common outcome data set for fall injury prevention trials: the prevention of falls network Europe consensus. J Am Geriatr Soc 53(9):1618–1622PubMedCrossRef
24.
Zurück zum Zitat WHO/IASO/IOTF (2000) The Asia-Pacific perspective: redefining obesity and its treatment. Health Communication Australia, Melbourne WHO/IASO/IOTF (2000) The Asia-Pacific perspective: redefining obesity and its treatment. Health Communication Australia, Melbourne
25.
Zurück zum Zitat Bauer DC, Gluer CC, Cauley JA et al (1997) Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Arch Intern Med 157:629–634PubMedCrossRef Bauer DC, Gluer CC, Cauley JA et al (1997) Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Arch Intern Med 157:629–634PubMedCrossRef
26.
Zurück zum Zitat Khaw KT, Reeve J, Luben R et al (2004) Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study. Lancet 363:197–202PubMedCrossRef Khaw KT, Reeve J, Luben R et al (2004) Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study. Lancet 363:197–202PubMedCrossRef
27.
Zurück zum Zitat Hans D, Dargent-Molina P, Schott AM et al (1996) Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet 348:511–514PubMedCrossRef Hans D, Dargent-Molina P, Schott AM et al (1996) Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet 348:511–514PubMedCrossRef
28.
Zurück zum Zitat Fillenbaum GG, Smyer MA (1981) The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. J Gerontol 36:428–434PubMed Fillenbaum GG, Smyer MA (1981) The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. J Gerontol 36:428–434PubMed
29.
Zurück zum Zitat Chiu HC, Chen YC, Mau LW, Shiao SH, Liu HW, Huang MS (1997) An evaluation of the reliability and validity of the Chinese-version OARS multidimensional functional assessment questionnaire. Chin J Public Health Taipei 16(2):119–132 Chiu HC, Chen YC, Mau LW, Shiao SH, Liu HW, Huang MS (1997) An evaluation of the reliability and validity of the Chinese-version OARS multidimensional functional assessment questionnaire. Chin J Public Health Taipei 16(2):119–132
30.
Zurück zum Zitat Pfeiffer E (1975) A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatr Soc 23:433–441PubMed Pfeiffer E (1975) A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatr Soc 23:433–441PubMed
31.
Zurück zum Zitat Liu CK, Tai CT, Lin RT, Chen YF, Lai CL (1996) Validation of Short Portable Mental Status Questionnaire. The 5th Annual Meeting of the Gerontological Society, Taiwan, R.O.C. p. 41 Liu CK, Tai CT, Lin RT, Chen YF, Lai CL (1996) Validation of Short Portable Mental Status Questionnaire. The 5th Annual Meeting of the Gerontological Society, Taiwan, R.O.C. p. 41
32.
Zurück zum Zitat Sheikh JA, Yessavage JA (1986) Geriatric Depression Scale (GDS): recent findings and development of a shorter version. In: Brink TL (ed) Clinical gerontology: a guide to assessment and intervention. Howarth Press, New York Sheikh JA, Yessavage JA (1986) Geriatric Depression Scale (GDS): recent findings and development of a shorter version. In: Brink TL (ed) Clinical gerontology: a guide to assessment and intervention. Howarth Press, New York
33.
Zurück zum Zitat Liao YC, Yeh TL, Ko HC et al (1995) Geriatric Depression Scale—validity and reliability of the Chinese-translated version: a preliminary study. Med J Changhua Christ Hosp ROC 1:11–17 Liao YC, Yeh TL, Ko HC et al (1995) Geriatric Depression Scale—validity and reliability of the Chinese-translated version: a preliminary study. Med J Changhua Christ Hosp ROC 1:11–17
34.
Zurück zum Zitat Mickey RM, Greenland S (1989) The impact of confounder selection criteria on effect estimation. Am J Epidemiol 129:125–137PubMed Mickey RM, Greenland S (1989) The impact of confounder selection criteria on effect estimation. Am J Epidemiol 129:125–137PubMed
35.
Zurück zum Zitat de Bakker PM, Manske SL, Ebacher V, Oxland TR, Cripton PA, Guy P (2009) During sideways falls proximal femur fractures initiate in the superolateral cortex: evidence from high-speed video of simulated fractures. J Biomech 42:1917–1925PubMedCrossRef de Bakker PM, Manske SL, Ebacher V, Oxland TR, Cripton PA, Guy P (2009) During sideways falls proximal femur fractures initiate in the superolateral cortex: evidence from high-speed video of simulated fractures. J Biomech 42:1917–1925PubMedCrossRef
36.
Zurück zum Zitat Parkkari J, Kannus P, Palvanen M et al (1999) Majority of hip fractures occur as a result of a fall and impact on the greater trochanter of the femur: a prospective controlled hip fracture study with 206 consecutive patients. Calcif Tissue Int 65(3):183–187PubMedCrossRef Parkkari J, Kannus P, Palvanen M et al (1999) Majority of hip fractures occur as a result of a fall and impact on the greater trochanter of the femur: a prospective controlled hip fracture study with 206 consecutive patients. Calcif Tissue Int 65(3):183–187PubMedCrossRef
37.
Zurück zum Zitat Sabick MB, Hay JG, Goel VK, Banks SA (1999) Active responses decrease impact forces at the hip and shoulder in falls to the side. J Biomech 32:993–998PubMedCrossRef Sabick MB, Hay JG, Goel VK, Banks SA (1999) Active responses decrease impact forces at the hip and shoulder in falls to the side. J Biomech 32:993–998PubMedCrossRef
38.
Zurück zum Zitat Mussolino ME (2005) Depression and hip fracture risk: the NHANES I epidemiologic follow-up study. Public Health Rep 120(1):71–75PubMed Mussolino ME (2005) Depression and hip fracture risk: the NHANES I epidemiologic follow-up study. Public Health Rep 120(1):71–75PubMed
39.
Zurück zum Zitat Whooley MA, Kip KE, Cauley JA, Ensrud KE, Nevitt MC, Browner WS (1999) Depression, falls, and risk of fracture in older women. Study of osteoporotic fractures research group. Arch Intern Med 159(5):484–490PubMedCrossRef Whooley MA, Kip KE, Cauley JA, Ensrud KE, Nevitt MC, Browner WS (1999) Depression, falls, and risk of fracture in older women. Study of osteoporotic fractures research group. Arch Intern Med 159(5):484–490PubMedCrossRef
40.
Zurück zum Zitat Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LJ (1987) Psychotropic drug use and the risk of hip fracture. N Engl J Med 316(7):363–369PubMedCrossRef Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LJ (1987) Psychotropic drug use and the risk of hip fracture. N Engl J Med 316(7):363–369PubMedCrossRef
41.
Zurück zum Zitat Walter LC, Lui L-Y, Eng C, Covinsky KE (2003) Risk of in disabled community-living older adults. J Am Geriatr Soc 51:50–55PubMedCrossRef Walter LC, Lui L-Y, Eng C, Covinsky KE (2003) Risk of in disabled community-living older adults. J Am Geriatr Soc 51:50–55PubMedCrossRef
42.
Zurück zum Zitat Norton R, Butler M, Robinson E, Lee-Joe T, Campbell AJ (2000) Declines in physical functioning attributable to hip fracture among older people: a follow-up study of case-control participants. Disabil Rehabil 22:345–351PubMedCrossRef Norton R, Butler M, Robinson E, Lee-Joe T, Campbell AJ (2000) Declines in physical functioning attributable to hip fracture among older people: a follow-up study of case-control participants. Disabil Rehabil 22:345–351PubMedCrossRef
43.
Zurück zum Zitat Fransen M, Woodward M, Norton R, Robinson E, Butler M, Campbell AJ (2002) Excess mortality or institutionalization after hip fracture: men are at greater risk than women. J Am Geriatr Soc 50:685–690PubMedCrossRef Fransen M, Woodward M, Norton R, Robinson E, Butler M, Campbell AJ (2002) Excess mortality or institutionalization after hip fracture: men are at greater risk than women. J Am Geriatr Soc 50:685–690PubMedCrossRef
44.
Zurück zum Zitat Forsen L, Sogaard AJ, Meyer HE, Edna T, Kopjar B (1999) Survival after hip fracture: short- and long-term excess mortality according to age and gender. Osteoporos Int 10:73–78PubMedCrossRef Forsen L, Sogaard AJ, Meyer HE, Edna T, Kopjar B (1999) Survival after hip fracture: short- and long-term excess mortality according to age and gender. Osteoporos Int 10:73–78PubMedCrossRef
45.
Zurück zum Zitat Stenvall M, Elinge E, von Heideken WP, Lundström M, Gustafson Y, Nyberg L (2005) Having had a hip fracture: association with dependency among the oldest old. Age Ageing 34:294–297PubMedCrossRef Stenvall M, Elinge E, von Heideken WP, Lundström M, Gustafson Y, Nyberg L (2005) Having had a hip fracture: association with dependency among the oldest old. Age Ageing 34:294–297PubMedCrossRef
46.
Zurück zum Zitat Nakamura K, Takahashi S, Oyama M et al (2009) Incidence and risk factors associated with hip fracture in institutionalized elderly people in Japan. Age Ageing 38(4):478–482PubMedCrossRef Nakamura K, Takahashi S, Oyama M et al (2009) Incidence and risk factors associated with hip fracture in institutionalized elderly people in Japan. Age Ageing 38(4):478–482PubMedCrossRef
47.
Zurück zum Zitat Volpato S, Leveille SG, Blaum C, Fried LP, Guralnik JM (2005) Risk factors for falls in older disabled women with diabetes: the Women's Health and Aging Study. J Gerontol A Biol Sci Med Sci 60A:1539–1545CrossRef Volpato S, Leveille SG, Blaum C, Fried LP, Guralnik JM (2005) Risk factors for falls in older disabled women with diabetes: the Women's Health and Aging Study. J Gerontol A Biol Sci Med Sci 60A:1539–1545CrossRef
48.
Zurück zum Zitat Wallace C, Reiber GE, LeMaster J et al (2002) Incidence of falls, risk factors for falls, and fall-related fractures in individuals with diabetes and a prior foot ulcer. Diabet Care 11:1983–1986CrossRef Wallace C, Reiber GE, LeMaster J et al (2002) Incidence of falls, risk factors for falls, and fall-related fractures in individuals with diabetes and a prior foot ulcer. Diabet Care 11:1983–1986CrossRef
49.
Zurück zum Zitat Ivers RQ, Cumming RG, Mitchell P, Peduto AJ (2001) Diabetes and risk of fracture: the Blue Mountains Eye Study. Diabet Care 24:1198–1203CrossRef Ivers RQ, Cumming RG, Mitchell P, Peduto AJ (2001) Diabetes and risk of fracture: the Blue Mountains Eye Study. Diabet Care 24:1198–1203CrossRef
50.
Zurück zum Zitat UK Prospective Diabetes Study Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837–853CrossRef UK Prospective Diabetes Study Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837–853CrossRef
51.
Zurück zum Zitat Cavanagh PR, Derr JA, Ulbrecht JS, Maser RE, Orchard JJ (1992) Problems with gait and posture in neuropathic patients with insulin-dependent diabetes mellitus. Diabet Med 9:469–474PubMedCrossRef Cavanagh PR, Derr JA, Ulbrecht JS, Maser RE, Orchard JJ (1992) Problems with gait and posture in neuropathic patients with insulin-dependent diabetes mellitus. Diabet Med 9:469–474PubMedCrossRef
52.
Zurück zum Zitat Cauley JA, Robbins J, Chen Z et al (2003) Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA 290:1729–1738PubMedCrossRef Cauley JA, Robbins J, Chen Z et al (2003) Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA 290:1729–1738PubMedCrossRef
53.
Zurück zum Zitat Collaborative Group on Hormonal Factors in Breast Cancer (1997) Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer. Lancet 350:1047–1059CrossRef Collaborative Group on Hormonal Factors in Breast Cancer (1997) Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer. Lancet 350:1047–1059CrossRef
54.
Zurück zum Zitat Beresford SAA, Weiss NS, Voigt LF, McKnight B (1997) Risk of endometrial cancer in relation to use of estrogen combined with cyclic progestagen therapy in postmenopausal women. Lancet 349:458–461PubMedCrossRef Beresford SAA, Weiss NS, Voigt LF, McKnight B (1997) Risk of endometrial cancer in relation to use of estrogen combined with cyclic progestagen therapy in postmenopausal women. Lancet 349:458–461PubMedCrossRef
55.
Zurück zum Zitat Jick H, Derby LE, Myers MW, Vasilakis C, Newton KM (1996) Risk of hospital admission for idiopathic venous thromboembolism among users of post-menopausal estrogens. Lancet 348:981–983PubMedCrossRef Jick H, Derby LE, Myers MW, Vasilakis C, Newton KM (1996) Risk of hospital admission for idiopathic venous thromboembolism among users of post-menopausal estrogens. Lancet 348:981–983PubMedCrossRef
56.
Zurück zum Zitat Vestergaard P, Rejnmark L, Mosekilde L (2001) Hip fracture prevention – cost-effective strategies. Pharmcoeconomics 19:449–468CrossRef Vestergaard P, Rejnmark L, Mosekilde L (2001) Hip fracture prevention – cost-effective strategies. Pharmcoeconomics 19:449–468CrossRef
Metadaten
Titel
Fall mechanisms, bone strength, and hip fractures in elderly men and women in Taiwan
verfasst von
H.-F. Hwang
H.-D. Lee
H.-H. Huang
C.-Y. Chen
M.-R. Lin
Publikationsdatum
01.08.2011
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 8/2011
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-010-1446-4

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