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Osteoporosis International

Erschienen in:

01.12.2011 | Letter to the Editor

Re: The calcium scare: what would Austin Bradford Hill have thought?

verfasst von: M. J. Bolland, A. Grey, I. R. Reid

Erschienen in: Osteoporosis International | Ausgabe 12/2011

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Excerpt

Many of the issues raised by Nordin and colleagues [1] about our meta-analysis of the effects of calcium supplements on cardiovascular events [2] have been extensively addressed in the BMJ [3, 4] and in a review in Osteoporosis International [5]. It is unnecessary to repeat these responses, but we do wish to address new assertions and highlight errors in their analysis. …

Nordin BE, Lewis JR, Daly RM et al. (2011) The calcium scare—what would Austin Bradford Hill have thought? Osteoporos Int. doi:10.1007/s00198-011-1680-4

Bolland MJ, Avenell A, Baron JA et al (2010) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 341:c3691PubMedCrossRef

Bolland MJ, Avenell A, Baron JA et al. (2010) Calcium and cardiovascular risk- author response. BMJ http://www.bmj.com/content/341/bmj.c3691/reply#bmj_el_240991. Accessed 5 Sept 2011

Bolland MJ, Avenell A, Baron JA et al. (2010) Calcium and cardiovascular risk- author response to further issues. BMJ http://www.bmj.com/content/341/bmj.c3691/reply#bmj_el_240994. Accessed 5 Sept 2011

Reid IR, Bolland MJ, Avenell A et al (2011) Cardiovascular effects of calcium supplementation. Osteoporos Int 22:1649–1658PubMedCrossRef

Bolland MJ, Barber PA, Doughty RN et al (2008) Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 336:262–266PubMedCrossRef

Hill AB (1965) The environment and disease: association or causation? Proc R Soc Med 58:295–300PubMed

Demer LL (1995) A skeleton in the atherosclerosis closet. Circulation 92:2029–2032PubMed

Ronni-Sivula H (1985) Causes of death in patients previously operated on for primary hyperparathyroidism. Ann Chir Gynaecol 74:13–18PubMed

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Palmer M, Adami HO, Bergstrom R et al (1987) Survival and renal function in untreated hypercalcaemia. Population-based cohort study with 14 years of follow-up. Lancet 1:59–62PubMedCrossRef

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12.

Lundgren E, Lind L, Palmer M et al (2001) Increased cardiovascular mortality and normalized serum calcium in patients with mild hypercalcemia followed up for 25 years. Surgery 130:978–985PubMedCrossRef

13.

Nilsson IL, Yin L, Lundgren E et al (2002) Clinical presentation of primary hyperparathyroidism in Europe—nationwide cohort analysis on mortality from nonmalignant causes. J Bone Miner Res 17(Suppl 2):N68–N74PubMed

14.

Vestergaard P, Mollerup CL, Frokjaer VG et al (2003) Cardiovascular events before and after surgery for primary hyperparathyroidism. World J Surg 27:216–222PubMedCrossRef

15.

Ogard CG, Engholm G, Almdal TP et al (2004) Increased mortality in patients hospitalized with primary hyperparathyroidism during the period 1977–1993 in Denmark. World J Surg 28:108–111PubMedCrossRef

16.

Bolland MJ, Grey A, Reid IR (2011) Calcium supplements and cardiovascular risk. J Bone Miner Res 26:899PubMedCrossRef

17.

Bolland MJ, Grey A, Avenell A et al (2011) Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 342:d2040PubMedCrossRef

18.

Tang BMP, Eslick GD, Nowson C et al (2007) Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 370:657–666PubMedCrossRef

19.

DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) Group (2010) Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 340:b5463CrossRef

20.

Reid IR, Bolland MJ, Grey A (2008) Effect of calcium supplementation on hip fractures. Osteoporos Int 19:1119–1123PubMedCrossRef

21.

Grant AM, Avenell A, Campbell MK et al (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365:1621–1628PubMedCrossRef

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Jackson RD, LaCroix AZ, Gass M et al (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354:669–683PubMedCrossRef

23.

Prince RL, Devine A, Dhaliwal SS et al (2006) Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 166:869–875PubMedCrossRef

24.

Reid IR, Mason B, Horne A et al (2006) Randomized controlled trial of calcium in healthy older women. Am J Med 119:777–785PubMedCrossRef

Titel: Re: The calcium scare: what would Austin Bradford Hill have thought?
verfasst von: M. J. Bolland
A. Grey
I. R. Reid
Publikationsdatum: 01.12.2011
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 12/2011
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-011-1783-y

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