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Osteoporosis International

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01.01.2013 | Original Article

Relationship between use of antidepressants and risk of fractures: a meta-analysis

verfasst von: V. Rabenda, D. Nicolet, C. Beaudart, O. Bruyère, J.-Y. Reginster

Erschienen in: Osteoporosis International | Ausgabe 1/2013

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Abstract

Summary

It has been shown that antidepressants would have a direct action on bone metabolism and would be associated with increased fracture risk. Results from this large meta-analysis show that both SSRIs and TCAs are associated with a moderate and clinically significant increase in the risk of fractures of all types.

Introduction

This study seeks to investigate the relationship between use of antidepressants and the risk of fracture.

Methods

An exhaustive systematic research of case–control and cohort studies published or performed between 1966 and April 2011 that reported risk estimates of fracture associated with use of antidepressants was performed using MEDLINE, PsycINFO, and the Cochrane Systematic Review Database, manual review of the literature, and congressional abstracts. Inclusion, quality scoring, and data abstraction were performed systematically by three independent reviewers.

Results

A total of 34 studies (n = 1,217,464 individuals) were identified. Compared with non-users, the random effects pooled RR of fractures of all types, among antidepressant users, were 1.39 (95%CI 1.32–1.47). Use of antidepressants were associated with a 42 %, 47 %, and 38 % risk increase in non-vertebral, hip, and spine fractures, respectively ([For non-vertebral fractures: RR = 1.42, 95%CI 1.34–1.51]; [For hip fractures: RR = 1.47, 95%CI 1.36–1.58]; [For spine fractures: RR = 1.38, 95%CI 1.19–1.61]). Studies examining SSRI use showed systematically a higher increase in the risk of fractures of all types, non-vertebral, and hip fractures than studies evaluating TCA use.

Conclusions

Results from this large meta-analysis show that both SSRIs and TCAs are associated with a moderate and clinically significant increase in the risk of fractures of all types.

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Titel: Relationship between use of antidepressants and risk of fractures: a meta-analysis
verfasst von: V. Rabenda
D. Nicolet
C. Beaudart
O. Bruyère
J.-Y. Reginster
Publikationsdatum: 01.01.2013
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 1/2013
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-012-2015-9

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Relationship between use of antidepressants and risk of fractures: a meta-analysis

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