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Erschienen in: Osteoporosis International 5/2013

01.05.2013 | Opinion Paper

Vitamin D: do we get enough?

A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe

verfasst von: E. M. Brouwer-Brolsma, H. A. Bischoff-Ferrari, R. Bouillon, E. J. M. Feskens, C. J. Gallagher, E. Hypponen, D. J. Llewellyn, E. Stoecklin, J. Dierkes, A. K. Kies, F. J. Kok, C. Lamberg-Allardt, U. Moser, S. Pilz, W. H. Saris, N. M. van Schoor, P. Weber, R. Witkamp, A. Zittermann, L. C. P. G. M. de Groot

Erschienen in: Osteoporosis International | Ausgabe 5/2013

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Abstract

Summary

On September 29, 2011, acknowledged experts in the field of vitamin D, mainly European, were brought together in order to discuss the recent scientific advances in relation to vitamin D: the current requirements and associations with various health outcomes. In this article, the discussions resulting from the meeting are summarized.

Introduction

Several groups at risk for developing vitamin D insufficiency have been identified. Accordingly, reviews indicate that a significant percentage of the population worldwide have serum 25-hydroxyvitamin D levels below 50 nmol/l. In addition to the role of vitamin D in bone health, recent studies suggest that it may play a pivotal role in other systems, e.g., the cardiovascular system, pancreas, muscle, immune system and brain. Most evidence, however, is obtained from observational studies and yet inconclusive.

Methods

To exchange and broaden knowledge on the requirements for vitamin D and its effect on various health outcomes, a workshop entitled “Vitamin D Expert Meeting: Do we get enough?”, was organized.

Results

Despite low vitamin D levels worldwide, consensus on the definition of deficiency is not yet reached. In order to define cut-off points for vitamin D whilst taking into account extraskeletal health effects, randomized controlled trials in these fields are warranted. The experts do emphasize that there is evidence to suggest an important role for vitamin D in the maintenance of optimal bone health at all ages and that vitamin D supplementation, in most studies co-administered with calcium, reduces fracture risk in the senior population.

Conclusion

To reach a serum 25-hydroxyvitamin D level of 50 nmol/l older adults aged ≥65 years are therefore recommended to meet a mean daily vitamin D intake of 20 μg (800 IU), which is best achieved with a supplement.
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Literatur
1.
Zurück zum Zitat Mithal A, Wahl DA, Bonjour JP et al (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1820PubMedCrossRef Mithal A, Wahl DA, Bonjour JP et al (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1820PubMedCrossRef
3.
Zurück zum Zitat van Schoor NM, Lips P (2011) Worldwide vitamin D status. Best practice & research Clinical endocrinology & metabolism 25:671–680CrossRef van Schoor NM, Lips P (2011) Worldwide vitamin D status. Best practice & research Clinical endocrinology & metabolism 25:671–680CrossRef
4.
Zurück zum Zitat Bischoff-Ferrari HA, Can U, Staehelin HB, Platz A, Henschkowski J, Michel BA, Dawson-Hughes B, Theiler R (2008) Severe vitamin D deficiency in Swiss hip fracture patients. Bone 42:597–602PubMedCrossRef Bischoff-Ferrari HA, Can U, Staehelin HB, Platz A, Henschkowski J, Michel BA, Dawson-Hughes B, Theiler R (2008) Severe vitamin D deficiency in Swiss hip fracture patients. Bone 42:597–602PubMedCrossRef
5.
Zurück zum Zitat LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J (1999) Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA 281:1505–1511PubMedCrossRef LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J (1999) Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA 281:1505–1511PubMedCrossRef
6.
Zurück zum Zitat Bouillon R, Bischoff-Ferrari H, Willett W (2008) Vitamin D and health: perspectives from mice and man. J Bone Miner Res 23:974–979PubMedCrossRef Bouillon R, Bischoff-Ferrari H, Willett W (2008) Vitamin D and health: perspectives from mice and man. J Bone Miner Res 23:974–979PubMedCrossRef
7.
Zurück zum Zitat Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J (2009) Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 339:b3692PubMedCrossRef Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J (2009) Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 339:b3692PubMedCrossRef
8.
Zurück zum Zitat Ross AC, Taylor CL, Yaktine AL, Del Valle HB (eds) (2011) Dietary reference intakes for calcium and vitamin D Ross AC, Taylor CL, Yaktine AL, Del Valle HB (eds) (2011) Dietary reference intakes for calcium and vitamin D
9.
Zurück zum Zitat Muir SW, Montero-Odasso M (2011) Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc 59:2291–2300PubMedCrossRef Muir SW, Montero-Odasso M (2011) Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc 59:2291–2300PubMedCrossRef
10.
Zurück zum Zitat Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M (2008) Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29:726–776PubMedCrossRef Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M (2008) Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29:726–776PubMedCrossRef
11.
Zurück zum Zitat Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, Llewellyn DJ, Raina P (2012) Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology 79:1397–1405PubMedCrossRef Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, Llewellyn DJ, Raina P (2012) Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology 79:1397–1405PubMedCrossRef
12.
Zurück zum Zitat Mitri J, Muraru MD, Pittas AG (2011) Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr 65:1005–1015PubMedCrossRef Mitri J, Muraru MD, Pittas AG (2011) Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr 65:1005–1015PubMedCrossRef
13.
Zurück zum Zitat Ascherio A, Munger KL, Simon KC (2010) Vitamin D and multiple sclerosis. Lancet Neurol 9:599–612PubMedCrossRef Ascherio A, Munger KL, Simon KC (2010) Vitamin D and multiple sclerosis. Lancet Neurol 9:599–612PubMedCrossRef
14.
Zurück zum Zitat Grandi NC, Breitling LP, Brenner H (2010) Vitamin D and cardiovascular disease: systematic review and meta-analysis of prospective studies. Preventive medicine 51:228–233PubMedCrossRef Grandi NC, Breitling LP, Brenner H (2010) Vitamin D and cardiovascular disease: systematic review and meta-analysis of prospective studies. Preventive medicine 51:228–233PubMedCrossRef
15.
Zurück zum Zitat Fleet JC, DeSmet M, Johnson R, Li Y (2012) Vitamin D and cancer: a review of molecular mechanisms. Biochem J 441:61–76PubMedCrossRef Fleet JC, DeSmet M, Johnson R, Li Y (2012) Vitamin D and cancer: a review of molecular mechanisms. Biochem J 441:61–76PubMedCrossRef
16.
Zurück zum Zitat Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S (2012) Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr 95:91–100PubMedCrossRef Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S (2012) Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr 95:91–100PubMedCrossRef
17.
Zurück zum Zitat Schottker B, Ball D, Gellert C, Brenner H (2012) Serum 25-hydroxyvitamin D levels and overall mortality. A systematic review and meta-analysis of prospective cohort studies. Ageing Research Reviews Schottker B, Ball D, Gellert C, Brenner H (2012) Serum 25-hydroxyvitamin D levels and overall mortality. A systematic review and meta-analysis of prospective cohort studies. Ageing Research Reviews
18.
Zurück zum Zitat MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76:1536–1538PubMedCrossRef MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76:1536–1538PubMedCrossRef
19.
Zurück zum Zitat Holick MF (1995) Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr 61:638S–645SPubMed Holick MF (1995) Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr 61:638S–645SPubMed
20.
Zurück zum Zitat DGE, OGE, SGE, SVE (2012) Referenzwerte für die Nährstoffzufuhr Vitamin D. In. Deutsche Gesellschaft für Ernährung, Österreichische Gesellschaft für Ernährung, Schweizerische Gesellschaft für Ernährungsforschung, Schweizerische Vereinigung für Ernährung, Bonn DGE, OGE, SGE, SVE (2012) Referenzwerte für die Nährstoffzufuhr Vitamin D. In. Deutsche Gesellschaft für Ernährung, Österreichische Gesellschaft für Ernährung, Schweizerische Gesellschaft für Ernährungsforschung, Schweizerische Vereinigung für Ernährung, Bonn
21.
Zurück zum Zitat Health Council of Belgium (2009) Voedingsaanbevelingen voor België. Hoge Gezondheidsraad, Brussels Health Council of Belgium (2009) Voedingsaanbevelingen voor België. Hoge Gezondheidsraad, Brussels
22.
Zurück zum Zitat Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930PubMedCrossRef Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930PubMedCrossRef
23.
Zurück zum Zitat Becker W (2005) New Nordic nutrition recommendations 2004. Physical activity as important as good nourishing food]. Lakartidningen 102:2760–2752 Becker W (2005) New Nordic nutrition recommendations 2004. Physical activity as important as good nourishing food]. Lakartidningen 102:2760–2752
24.
Zurück zum Zitat Health Council of the Netherlands (2012) Evaluation of the dietary reference values for vitamin D. In. The Hague, p 90 Health Council of the Netherlands (2012) Evaluation of the dietary reference values for vitamin D. In. The Hague, p 90
25.
Zurück zum Zitat Doets EL, de Wit LS, Dhonukshe-Rutten RA et al (2008) Current micronutrient recommendations in Europe: towards understanding their differences and similarities. Eur J Nutr 47(Suppl 1):17–40PubMedCrossRef Doets EL, de Wit LS, Dhonukshe-Rutten RA et al (2008) Current micronutrient recommendations in Europe: towards understanding their differences and similarities. Eur J Nutr 47(Suppl 1):17–40PubMedCrossRef
26.
Zurück zum Zitat Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, Josse RG, Lips P, Morales-Torres J, Yoshimura N (2010) IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 21:1151–1154PubMedCrossRef Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, Josse RG, Lips P, Morales-Torres J, Yoshimura N (2010) IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 21:1151–1154PubMedCrossRef
27.
Zurück zum Zitat Trivedi DP, Doll R, Khaw KT (2003) Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 326:469PubMedCrossRef Trivedi DP, Doll R, Khaw KT (2003) Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 326:469PubMedCrossRef
28.
Zurück zum Zitat Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC (2010) Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 303:1815–1822PubMedCrossRef Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC (2010) Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 303:1815–1822PubMedCrossRef
29.
Zurück zum Zitat Smith H, Anderson F, Raphael H, Maslin P, Crozier S, Cooper C (2007) Effect of annual intramuscular vitamin D on fracture risk in elderly men and women—a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology 46:1852–1857PubMedCrossRef Smith H, Anderson F, Raphael H, Maslin P, Crozier S, Cooper C (2007) Effect of annual intramuscular vitamin D on fracture risk in elderly men and women—a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology 46:1852–1857PubMedCrossRef
30.
Zurück zum Zitat Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J (2009) Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 169:551–561PubMedCrossRef Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J (2009) Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 169:551–561PubMedCrossRef
31.
Zurück zum Zitat Sai AJ, Walters RW, Fang X, Gallagher JC (2011) Relationship between vitamin D, parathyroid hormone, and bone health. J Clin Endocrinol Metab 96:E436–446PubMedCrossRef Sai AJ, Walters RW, Fang X, Gallagher JC (2011) Relationship between vitamin D, parathyroid hormone, and bone health. J Clin Endocrinol Metab 96:E436–446PubMedCrossRef
32.
Zurück zum Zitat Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B (2004) Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 116:634–639PubMedCrossRef Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B (2004) Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 116:634–639PubMedCrossRef
33.
Zurück zum Zitat Lips P, van Schoor NM (2011) The effect of vitamin D on bone and osteoporosis. Best practice & research Clinical endocrinology & metabolism 25:585–591CrossRef Lips P, van Schoor NM (2011) The effect of vitamin D on bone and osteoporosis. Best practice & research Clinical endocrinology & metabolism 25:585–591CrossRef
34.
Zurück zum Zitat Wahl DAC C,Ebeling PR, Eggersdorfer M, Hilger J, Hoffmann K, Josse R, Kanis JA, Mithal A, Pierroz DD, Stenmark J, Stöcklin E, Dawson-Hughes B (2012) A global representation of Vitamin D status in healthy populations. Archives of Osteoporosis Wahl DAC C,Ebeling PR, Eggersdorfer M, Hilger J, Hoffmann K, Josse R, Kanis JA, Mithal A, Pierroz DD, Stenmark J, Stöcklin E, Dawson-Hughes B (2012) A global representation of Vitamin D status in healthy populations. Archives of Osteoporosis
35.
Zurück zum Zitat Wang TJ, Zhang F, Richards JB et al (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376:180–188PubMedCrossRef Wang TJ, Zhang F, Richards JB et al (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376:180–188PubMedCrossRef
36.
Zurück zum Zitat Hypponen E (2010) Vitamin D and increasing incidence of type 1 diabetes—evidence for an association? Diabetes, obesity & metabolism 12:737–743CrossRef Hypponen E (2010) Vitamin D and increasing incidence of type 1 diabetes—evidence for an association? Diabetes, obesity & metabolism 12:737–743CrossRef
37.
Zurück zum Zitat Cooper JD, Smyth DJ, Walker NM et al (2011) Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 60:1624–1631PubMedCrossRef Cooper JD, Smyth DJ, Walker NM et al (2011) Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 60:1624–1631PubMedCrossRef
38.
Zurück zum Zitat Hypponen E, Boucher BJ, Berry DJ, Power C (2008) 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes 57:298–305PubMedCrossRef Hypponen E, Boucher BJ, Berry DJ, Power C (2008) 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes 57:298–305PubMedCrossRef
39.
Zurück zum Zitat Berry DJ, Hesketh K, Power C, Hypponen E (2011) Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr 1–8 Berry DJ, Hesketh K, Power C, Hypponen E (2011) Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr 1–8
40.
Zurück zum Zitat Lehouck A, Mathieu C, Carremans C, Baeke F, Verhaegen J, Van Eldere J, Decallonne B, Bouillon R, Decramer M, Janssens W (2012) High doses of vitamin d to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med 156:105–114PubMedCrossRef Lehouck A, Mathieu C, Carremans C, Baeke F, Verhaegen J, Van Eldere J, Decallonne B, Bouillon R, Decramer M, Janssens W (2012) High doses of vitamin d to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med 156:105–114PubMedCrossRef
41.
Zurück zum Zitat Rosen CJ, Abrams SA, Aloia JF et al (2012) IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab 97:1146–1152PubMedCrossRef Rosen CJ, Abrams SA, Aloia JF et al (2012) IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab 97:1146–1152PubMedCrossRef
43.
Zurück zum Zitat Broe KE, Chen TC, Weinberg J, Bischoff-Ferrari HA, Holick MF, Kiel DP (2007) A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc 55:234–239PubMedCrossRef Broe KE, Chen TC, Weinberg J, Bischoff-Ferrari HA, Holick MF, Kiel DP (2007) A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc 55:234–239PubMedCrossRef
44.
Zurück zum Zitat Glendenning P, Zhu K, Inderjeeth C, Howat P, Lewis JR, Prince RL (2012) Effects of three monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility and muscle strength in older postmenopausal women: a randomised controlled trial. J Bone Miner Res 27(1):170–176 Glendenning P, Zhu K, Inderjeeth C, Howat P, Lewis JR, Prince RL (2012) Effects of three monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility and muscle strength in older postmenopausal women: a randomised controlled trial. J Bone Miner Res 27(1):170–176
45.
Zurück zum Zitat Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P (2007) Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 92:1415–1423PubMedCrossRef Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P (2007) Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 92:1415–1423PubMedCrossRef
46.
Zurück zum Zitat Cranney A, Horsley T, O'Donnell S et al (2007) Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep) 1–235 Cranney A, Horsley T, O'Donnell S et al (2007) Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep) 1–235
47.
Zurück zum Zitat Group D (2010) Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 340:b5463CrossRef Group D (2010) Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 340:b5463CrossRef
48.
Zurück zum Zitat Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A (2007) Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 370:657–666PubMedCrossRef Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A (2007) Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 370:657–666PubMedCrossRef
49.
Zurück zum Zitat Bischoff-Ferrari HA, Willett WC, Orav EJ et al (2012) A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 367:40–49PubMedCrossRef Bischoff-Ferrari HA, Willett WC, Orav EJ et al (2012) A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 367:40–49PubMedCrossRef
50.
Zurück zum Zitat Gallagher JC, Rosen C (2011) Institute of Medicine responds. Fall prevention with vitamin D. BMJ 342:d4046PubMedCrossRef Gallagher JC, Rosen C (2011) Institute of Medicine responds. Fall prevention with vitamin D. BMJ 342:d4046PubMedCrossRef
51.
Zurück zum Zitat da Silva JA (2011) Fall prevention with vitamin D. Clarifications needed, please. BMJ 342:d2602PubMedCrossRef da Silva JA (2011) Fall prevention with vitamin D. Clarifications needed, please. BMJ 342:d2602PubMedCrossRef
52.
Zurück zum Zitat Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA: the journal of the American Medical Association 293:2257–2264CrossRef Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA: the journal of the American Medical Association 293:2257–2264CrossRef
53.
54.
Zurück zum Zitat Grey A, Bolland MJ, Reid IR (2012) Vitamin D dose requirements for fracture prevention. N Engl J Med 367:1367–1368, author reply 1369–1370PubMedCrossRef Grey A, Bolland MJ, Reid IR (2012) Vitamin D dose requirements for fracture prevention. N Engl J Med 367:1367–1368, author reply 1369–1370PubMedCrossRef
55.
Zurück zum Zitat Ott SM (2012) Vitamin D dose requirements for fracture prevention. N Engl J Med 367:1367, author reply 1369–1370PubMedCrossRef Ott SM (2012) Vitamin D dose requirements for fracture prevention. N Engl J Med 367:1367, author reply 1369–1370PubMedCrossRef
56.
Zurück zum Zitat Paterson CR (2012) Vitamin D dose requirements for fracture prevention. N Engl J Med 367:1368–1369, author reply 1370PubMed Paterson CR (2012) Vitamin D dose requirements for fracture prevention. N Engl J Med 367:1368–1369, author reply 1370PubMed
57.
Zurück zum Zitat Rosen CJ, Mayne ST (2012) D IOMCoDRIfV, Calcium Vitamin D dose requirements for fracture prevention. The New England journal of medicine 367:1368, author reply 1369–1370PubMed Rosen CJ, Mayne ST (2012) D IOMCoDRIfV, Calcium Vitamin D dose requirements for fracture prevention. The New England journal of medicine 367:1368, author reply 1369–1370PubMed
58.
Zurück zum Zitat Ceglia L, Harris SS (2012) Vitamin D and its role in skeletal muscle. Calcif Tissue Int Ceglia L, Harris SS (2012) Vitamin D and its role in skeletal muscle. Calcif Tissue Int
60.
Zurück zum Zitat Bischoff HA, Stahelin HB, Dick W et al (2003) Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18:343–351PubMedCrossRef Bischoff HA, Stahelin HB, Dick W et al (2003) Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18:343–351PubMedCrossRef
61.
Zurück zum Zitat Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H (2009) Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 20:315–322PubMedCrossRef Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H (2009) Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 20:315–322PubMedCrossRef
62.
Zurück zum Zitat Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C (2000) Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 15:1113–1118PubMedCrossRef Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C (2000) Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 15:1113–1118PubMedCrossRef
63.
Zurück zum Zitat Bischoff-Ferrari HA (2011) The role of falls in fracture prediction. Current osteoporosis reports 9:116–121PubMedCrossRef Bischoff-Ferrari HA (2011) The role of falls in fracture prediction. Current osteoporosis reports 9:116–121PubMedCrossRef
64.
Zurück zum Zitat Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL (2011) Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int 22:859–871PubMed Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL (2011) Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int 22:859–871PubMed
65.
Zurück zum Zitat Freedman LP (1999) Transcriptional targets of the vitamin D3 receptor-mediating cell cycle arrest and differentiation. J Nutr 129:581S–586SPubMed Freedman LP (1999) Transcriptional targets of the vitamin D3 receptor-mediating cell cycle arrest and differentiation. J Nutr 129:581S–586SPubMed
66.
Zurück zum Zitat Sorensen OH, Lund B, Saltin B, Andersen RB, Hjorth L, Melsen F, Mosekilde L (1979) Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clin Sci 56:157–161PubMed Sorensen OH, Lund B, Saltin B, Andersen RB, Hjorth L, Melsen F, Mosekilde L (1979) Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clin Sci 56:157–161PubMed
67.
Zurück zum Zitat Wang Y, DeLuca HF (2011) Is the vitamin d receptor found in muscle? Endocrinology 152:354–363PubMedCrossRef Wang Y, DeLuca HF (2011) Is the vitamin d receptor found in muscle? Endocrinology 152:354–363PubMedCrossRef
68.
Zurück zum Zitat Baynes KC, Boucher BJ, Feskens EJ, Kromhout D (1997) Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia 40:344–347PubMedCrossRef Baynes KC, Boucher BJ, Feskens EJ, Kromhout D (1997) Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia 40:344–347PubMedCrossRef
69.
Zurück zum Zitat Jarrett RJ, Murrells TJ, Shipley MJ, Hall T (1984) Screening blood glucose values: effects of season and time of day. Diabetologia 27:574–577PubMedCrossRef Jarrett RJ, Murrells TJ, Shipley MJ, Hall T (1984) Screening blood glucose values: effects of season and time of day. Diabetologia 27:574–577PubMedCrossRef
70.
Zurück zum Zitat Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017–2029PubMedCrossRef Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017–2029PubMedCrossRef
71.
Zurück zum Zitat Brouwer-Brolsma EM, Feskens EJ, Steegenga WT, de Groot LC (2012) Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study. Eur J Nutr Brouwer-Brolsma EM, Feskens EJ, Steegenga WT, de Groot LC (2012) Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study. Eur J Nutr
72.
Zurück zum Zitat Alvarez JA, Ashraf A (2010) Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol 2010:351385PubMed Alvarez JA, Ashraf A (2010) Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol 2010:351385PubMed
73.
Zurück zum Zitat Poole KE, Loveridge N, Barker PJ, Halsall DJ, Rose C, Reeve J, Warburton EA (2006) Reduced vitamin D in acute stroke. Stroke; a journal of cerebral circulation 37:243–245PubMedCrossRef Poole KE, Loveridge N, Barker PJ, Halsall DJ, Rose C, Reeve J, Warburton EA (2006) Reduced vitamin D in acute stroke. Stroke; a journal of cerebral circulation 37:243–245PubMedCrossRef
74.
Zurück zum Zitat Llewellyn DJ, Langa KM, Lang IA (2009) Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol 22:188–195PubMedCrossRef Llewellyn DJ, Langa KM, Lang IA (2009) Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol 22:188–195PubMedCrossRef
75.
Zurück zum Zitat Llewellyn DJ, Lang IA, Langa KM, Melzer D (2010) Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol A Biol Sci Med Sci 66:59–65PubMed Llewellyn DJ, Lang IA, Langa KM, Melzer D (2010) Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol A Biol Sci Med Sci 66:59–65PubMed
76.
Zurück zum Zitat Buell JS, Dawson-Hughes B (2008) Vitamin D and neurocognitive dysfunction: preventing "D"ecline? Mol Aspects Med 29:415–422PubMedCrossRef Buell JS, Dawson-Hughes B (2008) Vitamin D and neurocognitive dysfunction: preventing "D"ecline? Mol Aspects Med 29:415–422PubMedCrossRef
77.
Zurück zum Zitat Dickens AP, Lang IA, Langa KM, Kos K, Llewellyn DJ (2011) Vitamin D, cognitive dysfunction and dementia in older adults. CNS drugs 25:629–639PubMedCrossRef Dickens AP, Lang IA, Langa KM, Kos K, Llewellyn DJ (2011) Vitamin D, cognitive dysfunction and dementia in older adults. CNS drugs 25:629–639PubMedCrossRef
78.
Zurück zum Zitat Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2010) Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med 170:1135–1141PubMedCrossRef Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D (2010) Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med 170:1135–1141PubMedCrossRef
79.
Zurück zum Zitat Slinin Y, Paudel ML, Taylor BC et al (2010) 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology 74:33–41PubMedCrossRef Slinin Y, Paudel ML, Taylor BC et al (2010) 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology 74:33–41PubMedCrossRef
80.
Zurück zum Zitat Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC (2010) Benefit-risk assessment of vitamin D supplementation. Osteoporos Int 21:1121–1132PubMedCrossRef Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC (2010) Benefit-risk assessment of vitamin D supplementation. Osteoporos Int 21:1121–1132PubMedCrossRef
81.
Zurück zum Zitat Priemel M, von Domarus C, Klatte TO et al (2010) Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 25:305–312PubMedCrossRef Priemel M, von Domarus C, Klatte TO et al (2010) Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 25:305–312PubMedCrossRef
82.
Zurück zum Zitat Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, Reid IR (2010) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 341:c3691PubMedCrossRef Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, Reid IR (2010) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 341:c3691PubMedCrossRef
83.
Zurück zum Zitat Gallagher JC, Sai A, Templin T 2nd, Smith L (2012) Dose response to vitamin d supplementation in postmenopausal women: a randomized trial. Ann Intern Med 156:425–437PubMedCrossRef Gallagher JC, Sai A, Templin T 2nd, Smith L (2012) Dose response to vitamin d supplementation in postmenopausal women: a randomized trial. Ann Intern Med 156:425–437PubMedCrossRef
84.
Zurück zum Zitat Jackson RD, LaCroix AZ, Gass M et al (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354:669–683PubMedCrossRef Jackson RD, LaCroix AZ, Gass M et al (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354:669–683PubMedCrossRef
85.
Zurück zum Zitat Macdonald HM, Mavroeidi A, Fraser WD et al (2010) Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: a major cause for concern? Osteoporos Int 22:2461–2472PubMedCrossRef Macdonald HM, Mavroeidi A, Fraser WD et al (2010) Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: a major cause for concern? Osteoporos Int 22:2461–2472PubMedCrossRef
86.
Zurück zum Zitat Heaney RP, Recker RR, Grote J, Horst RL, Armas LA (2011) Vitamin D(3) is more potent than vitamin D(2) in humans. J Clin Endocrinol Metab 96:E447–452PubMedCrossRef Heaney RP, Recker RR, Grote J, Horst RL, Armas LA (2011) Vitamin D(3) is more potent than vitamin D(2) in humans. J Clin Endocrinol Metab 96:E447–452PubMedCrossRef
87.
Zurück zum Zitat Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, Reitz R, Salameh W, Ameri A, Tannenbaum AD (2008) Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 93:677–681PubMedCrossRef Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, Reitz R, Salameh W, Ameri A, Tannenbaum AD (2008) Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 93:677–681PubMedCrossRef
88.
Zurück zum Zitat Haussler MR, Whitfield GK, Kaneko I, Haussler CA, Hsieh D, Hsieh JC, Jurutka PW Molecular mechanisms of vitamin D action. Calcif Tissue Int Haussler MR, Whitfield GK, Kaneko I, Haussler CA, Hsieh D, Hsieh JC, Jurutka PW Molecular mechanisms of vitamin D action. Calcif Tissue Int
89.
Zurück zum Zitat Prentice A, Goldberg GR, Schoenmakers I (2008) Vitamin D across the lifecycle: physiology and biomarkers. Am J Clin Nutr 88:500S–506SPubMed Prentice A, Goldberg GR, Schoenmakers I (2008) Vitamin D across the lifecycle: physiology and biomarkers. Am J Clin Nutr 88:500S–506SPubMed
90.
Zurück zum Zitat Phinney KW, Bedner M, Tai SS et al (2012) Development and certification of a standard reference material for vitamin D metabolites in human serum. Anal Chem 84:956–962PubMedCrossRef Phinney KW, Bedner M, Tai SS et al (2012) Development and certification of a standard reference material for vitamin D metabolites in human serum. Anal Chem 84:956–962PubMedCrossRef
91.
Zurück zum Zitat Lips P, Duong T, Oleksik A, Black D, Cummings S, Cox D, Nickelsen T (2001) A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab 86:1212–1221PubMedCrossRef Lips P, Duong T, Oleksik A, Black D, Cummings S, Cox D, Nickelsen T (2001) A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab 86:1212–1221PubMedCrossRef
92.
Zurück zum Zitat Malabanan A, Veronikis IE, Holick MF (1998) Redefining vitamin D insufficiency. Lancet 351:805–806PubMedCrossRef Malabanan A, Veronikis IE, Holick MF (1998) Redefining vitamin D insufficiency. Lancet 351:805–806PubMedCrossRef
93.
Zurück zum Zitat Hansen KE, Jones AN, Lindstrom MJ, Davis LA, Engelke JA, Shafer MM (2008) Vitamin D insufficiency: disease or no disease? J Bone Miner Res 23:1052–1060PubMedCrossRef Hansen KE, Jones AN, Lindstrom MJ, Davis LA, Engelke JA, Shafer MM (2008) Vitamin D insufficiency: disease or no disease? J Bone Miner Res 23:1052–1060PubMedCrossRef
94.
Zurück zum Zitat Heaney RP (2007) The case for improving vitamin D status. J Steroid Biochem Mol Biol 103:635–641PubMedCrossRef Heaney RP (2007) The case for improving vitamin D status. J Steroid Biochem Mol Biol 103:635–641PubMedCrossRef
95.
Zurück zum Zitat Abrams SA, Griffin IJ, Hawthorne KM, Gunn SK, Gundberg CM, Carpenter TO (2005) Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents. J Clin Endocrinol Metab 90:5576–5581PubMedCrossRef Abrams SA, Griffin IJ, Hawthorne KM, Gunn SK, Gundberg CM, Carpenter TO (2005) Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents. J Clin Endocrinol Metab 90:5576–5581PubMedCrossRef
96.
Zurück zum Zitat Ooms ME, Lips P, Roos JC, van der Vijgh WJ, Popp-Snijders C, Bezemer PD, Bouter LM (1995) Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. J Bone Miner Res 10:1177–1184PubMedCrossRef Ooms ME, Lips P, Roos JC, van der Vijgh WJ, Popp-Snijders C, Bezemer PD, Bouter LM (1995) Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. J Bone Miner Res 10:1177–1184PubMedCrossRef
97.
Zurück zum Zitat Peacock M, Liu G, Carey M, McClintock R, Ambrosius W, Hui S, Johnston CC (2000) Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab 85:3011–3019PubMedCrossRef Peacock M, Liu G, Carey M, McClintock R, Ambrosius W, Hui S, Johnston CC (2000) Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab 85:3011–3019PubMedCrossRef
Metadaten
Titel
Vitamin D: do we get enough?
A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe
verfasst von
E. M. Brouwer-Brolsma
H. A. Bischoff-Ferrari
R. Bouillon
E. J. M. Feskens
C. J. Gallagher
E. Hypponen
D. J. Llewellyn
E. Stoecklin
J. Dierkes
A. K. Kies
F. J. Kok
C. Lamberg-Allardt
U. Moser
S. Pilz
W. H. Saris
N. M. van Schoor
P. Weber
R. Witkamp
A. Zittermann
L. C. P. G. M. de Groot
Publikationsdatum
01.05.2013
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 5/2013
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-012-2231-3

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