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Erschienen in: Osteoporosis International 4/2014

01.04.2014 | Original Article

Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study

verfasst von: L. Oei, N. Campos-Obando, A. Dehghan, E. H. G. Oei, L. Stolk, J. B. J. van Meurs, A. Hofman, A. G. Uitterlinden, O. H. Franco, M. C. Zillikens, F. Rivadeneira

Erschienen in: Osteoporosis International | Ausgabe 4/2014

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Abstract

Summary

Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal.

Introduction

Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort.

Methods

At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years).

Results

CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 cm3; −0.020 to −0.003 cm3) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (p = 9 × 10−56), but not with fracture risk (HR = 1.00; 0.99–1.00; p = 0.23).

Conclusions

Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk.
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Metadaten
Titel
Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study
verfasst von
L. Oei
N. Campos-Obando
A. Dehghan
E. H. G. Oei
L. Stolk
J. B. J. van Meurs
A. Hofman
A. G. Uitterlinden
O. H. Franco
M. C. Zillikens
F. Rivadeneira
Publikationsdatum
01.04.2014
Verlag
Springer London
Erschienen in
Osteoporosis International / Ausgabe 4/2014
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-013-2578-0

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