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Erschienen in: Osteoporosis International 4/2020

Open Access 14.11.2019 | Consensus Statement

Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps

verfasst von: N.R.W. Geiker, C. Mølgaard, S. Iuliano, R. Rizzoli, Y. Manios, L.J.C. van Loon, J.-M. Lecerf, G. Moschonis, J.-Y. Reginster, I. Givens, A. Astrup

Erschienen in: Osteoporosis International | Ausgabe 4/2020

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Abstract

Dairy products are included in dietary guidelines worldwide, as milk, yoghurt, and cheese are good sources of calcium and protein, vital nutrients for bones and muscle mass maintenance. Bone growth and mineralization occur during infancy and childhood, peak bone mass being attained after early adulthood. A low peak bone mass has consequences later in life, including increased risk of osteoporosis and fractures. Currently, more than 200 million people worldwide suffer from osteoporosis, with approximately 9 million fractures yearly. This poses a tremendous economic burden on health care. Between 5% and 10% of the elderly suffer from sarcopenia, the loss of muscle mass and strength, further increasing the risk of fractures due to falls. Evidence from interventional and observational studies support that fermented dairy products in particular exert beneficial effects on bone growth and mineralization, attenuation of bone loss, and reduce fracture risk. The effect cannot be explained by single nutrients in dairy, which suggests that a combined or matrix effect may be responsible similar to the matrix effects of foods on cardiometabolic health. Recently, several plant-based beverages and products have become available and marketed as substitutes for dairy products, even though their nutrient content differs substantially from dairy. Some of these products have been fortified, in efforts to mimic the nutritional profile of milk, but it is unknown whether the additives have the same bioavailability and beneficial effect as dairy. We conclude that the dairy matrix exerts an effect on bone and muscle health that is more than the sum of its nutrients, and we suggest that whole foods, not only single nutrients, need to be assessed in future observational and intervention studies of health outcomes. Furthermore, the importance of the matrix effect on health outcomes argues in favor of making future dietary guidelines food based.
Literatur
1.
Zurück zum Zitat Council N (2014) Nordic Nutrition Recommendations 2012: Integrating Nutrition and Physical Activity. Council N (2014) Nordic Nutrition Recommendations 2012: Integrating Nutrition and Physical Activity.
2.
Zurück zum Zitat Health UDo, Services H (2017) Dietary guidelines for Americans 2015–2020. Skyhorse Publishing Inc. Health UDo, Services H (2017) Dietary guidelines for Americans 2015–2020. Skyhorse Publishing Inc.
3.
Zurück zum Zitat Contento I, Balch G, Bronner Y, Paige D, Gross S, Bisignani L, Lytle L, Maloney S, White S, Olson C (1995) The effectiveness of nutrition education and implications for nutrition education policy, programs, and research: a review of research. J nutr educ 27 Contento I, Balch G, Bronner Y, Paige D, Gross S, Bisignani L, Lytle L, Maloney S, White S, Olson C (1995) The effectiveness of nutrition education and implications for nutrition education policy, programs, and research: a review of research. J nutr educ 27
4.
Zurück zum Zitat Organization WH (2018) Draft guidelines on saturated fatty acid and trans-fatty acid intake for adults and children. WHO https://extranet who int/dataform/upload/surveys/666752/files/Draft% 20WHO% 20SFA-TFA% 20guidelines_04052018% 20Public% 20Consultation (1) pdf Organization WH (2018) Draft guidelines on saturated fatty acid and trans-fatty acid intake for adults and children. WHO https://​extranet who int/dataform/upload/surveys/666752/files/Draft% 20WHO% 20SFA-TFA% 20guidelines_04052018% 20Public% 20Consultation (1) pdf
5.
Zurück zum Zitat Astrup A, Bertram HC, Bonjour J-P, de Groot LC, de Oliveira Otto MC, Feeney EL, Garg ML, Givens I, Kok FJ, Krauss RM, Lamarche B, Lecerf J-M, Legrand P, McKinley M, Micha R, Michalski M-C, Mozaffarian D, Soedamah-Muthu SS (2019) WHO draft guidelines on dietary saturated and trans fatty acids: time for a new approach? BMJ 366:l4137. https://doi.org/10.1136/bmj.l4137 CrossRefPubMed Astrup A, Bertram HC, Bonjour J-P, de Groot LC, de Oliveira Otto MC, Feeney EL, Garg ML, Givens I, Kok FJ, Krauss RM, Lamarche B, Lecerf J-M, Legrand P, McKinley M, Micha R, Michalski M-C, Mozaffarian D, Soedamah-Muthu SS (2019) WHO draft guidelines on dietary saturated and trans fatty acids: time for a new approach? BMJ 366:l4137. https://​doi.​org/​10.​1136/​bmj.​l4137 CrossRefPubMed
6.
Zurück zum Zitat Grosicki GJ, Fielding RA, Lustgarten MS (2018) Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle axis. Calcif tissue int 102(4):433–442PubMedCrossRef Grosicki GJ, Fielding RA, Lustgarten MS (2018) Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle axis. Calcif tissue int 102(4):433–442PubMedCrossRef
7.
Zurück zum Zitat Rizzoli R (2019) Nutritional influence on bone: role of gut microbiota. Aging clin exp res:1–9 Rizzoli R (2019) Nutritional influence on bone: role of gut microbiota. Aging clin exp res:1–9
8.
Zurück zum Zitat Nilsson A, Sundh D, Bäckhed F, Lorentzon M (2018) Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial. J intern med 284(3):307–317PubMedCrossRef Nilsson A, Sundh D, Bäckhed F, Lorentzon M (2018) Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial. J intern med 284(3):307–317PubMedCrossRef
9.
Zurück zum Zitat Curtis EM, Moon RJ, Harvey NC, Cooper C (2017) Reprint of: the impact of fragility fracture and approaches to osteoporosis risk assessment worldwide. Int j orthop trauma nurs 26:7–17PubMedPubMedCentralCrossRef Curtis EM, Moon RJ, Harvey NC, Cooper C (2017) Reprint of: the impact of fragility fracture and approaches to osteoporosis risk assessment worldwide. Int j orthop trauma nurs 26:7–17PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat Oden A, McCloskey EV, Kanis JA, Harvey NC, Johansson H (2015) Burden of high fracture probability worldwide: secular increases 2010–2040. Osteoporos Int 26(9):2243–2248PubMedCrossRef Oden A, McCloskey EV, Kanis JA, Harvey NC, Johansson H (2015) Burden of high fracture probability worldwide: secular increases 2010–2040. Osteoporos Int 26(9):2243–2248PubMedCrossRef
11.
Zurück zum Zitat Weaver C, Gordon C, Janz K, Kalkwarf H, Lappe JM, Lewis R, O’Karma M, Wallace T, Zemel B (2016) The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations. Osteoporos int 27(4):1281–1386PubMedPubMedCentralCrossRef Weaver C, Gordon C, Janz K, Kalkwarf H, Lappe JM, Lewis R, O’Karma M, Wallace T, Zemel B (2016) The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations. Osteoporos int 27(4):1281–1386PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA (2018) Sarcopenia: revised European consensus on definition and diagnosis. Age ageing 48(1):16–31PubMedCentralCrossRef Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA (2018) Sarcopenia: revised European consensus on definition and diagnosis. Age ageing 48(1):16–31PubMedCentralCrossRef
13.
Zurück zum Zitat Shafiee G, Keshtkar A, Soltani A, Ahadi Z, Larijani B, Heshmat R (2017) Prevalence of sarcopenia in the world: a systematic review and meta-analysis of general population studies. J Diabetes Metab Disord 16(1):21PubMedPubMedCentralCrossRef Shafiee G, Keshtkar A, Soltani A, Ahadi Z, Larijani B, Heshmat R (2017) Prevalence of sarcopenia in the world: a systematic review and meta-analysis of general population studies. J Diabetes Metab Disord 16(1):21PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Hunter GR, Singh H, Carter SJ, Bryan DR, Fisher G (2019) Sarcopenia and its implications for metabolic health. J obes 2019 Hunter GR, Singh H, Carter SJ, Bryan DR, Fisher G (2019) Sarcopenia and its implications for metabolic health. J obes 2019
15.
Zurück zum Zitat Cermak NM, Res PT, de Groot LC, Saris WH, Van Loon LJ (2012) Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. The Am j clin nutr 96(6):1454–1464PubMedCrossRef Cermak NM, Res PT, de Groot LC, Saris WH, Van Loon LJ (2012) Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. The Am j clin nutr 96(6):1454–1464PubMedCrossRef
16.
Zurück zum Zitat Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM (2009) Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J appl physiol 107(3):987–992PubMedCrossRef Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM (2009) Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J appl physiol 107(3):987–992PubMedCrossRef
17.
Zurück zum Zitat Durosier-Izart C, Biver E, Merminod F, van Rietbergen B, Chevalley T, Herrmann FR, Ferrari SL, Rizzoli R (2017) Peripheral skeleton bone strength is positively correlated with total and dairy protein intakes in healthy postmenopausal women. The Am j clin nutr 105(2):513–525PubMedCrossRef Durosier-Izart C, Biver E, Merminod F, van Rietbergen B, Chevalley T, Herrmann FR, Ferrari SL, Rizzoli R (2017) Peripheral skeleton bone strength is positively correlated with total and dairy protein intakes in healthy postmenopausal women. The Am j clin nutr 105(2):513–525PubMedCrossRef
18.
Zurück zum Zitat Rizzoli R (2014) Dairy products, yogurts, and bone health. The Am j clin nutr 99(5):1256S–1262SPubMedCrossRef Rizzoli R (2014) Dairy products, yogurts, and bone health. The Am j clin nutr 99(5):1256S–1262SPubMedCrossRef
19.
Zurück zum Zitat de Oliveira Otto MC, Mozaffarian D, Kromhout D, Bertoni AG, Sibley CT, Jacobs DR Jr, Nettleton JA (2012) Dietary intake of saturated fat by food source and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. The Am j clin nutr 96(2):397–404PubMedCrossRef de Oliveira Otto MC, Mozaffarian D, Kromhout D, Bertoni AG, Sibley CT, Jacobs DR Jr, Nettleton JA (2012) Dietary intake of saturated fat by food source and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. The Am j clin nutr 96(2):397–404PubMedCrossRef
20.
Zurück zum Zitat Weinberg LG, Berner LA, Groves JE (2004) Nutrient contributions of dairy foods in the United States, Continuing Survey of Food Intakes by Individuals, 1994–1996, 1998. J Am Diet Assoc 104(6):895–902PubMedCrossRef Weinberg LG, Berner LA, Groves JE (2004) Nutrient contributions of dairy foods in the United States, Continuing Survey of Food Intakes by Individuals, 1994–1996, 1998. J Am Diet Assoc 104(6):895–902PubMedCrossRef
21.
Zurück zum Zitat EFSA Panel on Dietetic Products N, Allergies (2010) Scientific opinion on establishing food-based dietary guidelines. EFSA Journal 8 (3):1460 EFSA Panel on Dietetic Products N, Allergies (2010) Scientific opinion on establishing food-based dietary guidelines. EFSA Journal 8 (3):1460
22.
Zurück zum Zitat Eckel RH, Jakicic JM, Ard JD, De Jesus JM, Miller NH, Hubbard VS, Lee I-M, Lichtenstein AH, Loria CM, Millen BE (2014) 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 63 (25_PA) Eckel RH, Jakicic JM, Ard JD, De Jesus JM, Miller NH, Hubbard VS, Lee I-M, Lichtenstein AH, Loria CM, Millen BE (2014) 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 63 (25_PA)
23.
Zurück zum Zitat Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, Franco OH, Butterworth AS, Forouhi NG, Thompson SG (2014) Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann int med 160(6):398–406PubMedCrossRef Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, Franco OH, Butterworth AS, Forouhi NG, Thompson SG (2014) Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann int med 160(6):398–406PubMedCrossRef
24.
Zurück zum Zitat Siri-Tarino PW, Sun Q, Hu FB, Krauss RM (2010) Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr atheroscler rep 12(6):384–390PubMedPubMedCentralCrossRef Siri-Tarino PW, Sun Q, Hu FB, Krauss RM (2010) Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr atheroscler rep 12(6):384–390PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat De Souza RJ, Mente A, Maroleanu A, Cozma AI, Ha V, Kishibe T, Uleryk E, Budylowski P, Schünemann H, Beyene J (2015) Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. Bmj 351:h3978PubMedPubMedCentralCrossRef De Souza RJ, Mente A, Maroleanu A, Cozma AI, Ha V, Kishibe T, Uleryk E, Budylowski P, Schünemann H, Beyene J (2015) Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. Bmj 351:h3978PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Pichler G, Amigo N, Tellez-Plaza M, Pardo-Cea M, Dominguez-Lucas A, Marrachelli V, Monleon D, Martin-Escudero JC, Ascaso J, Chaves F (2018) LDL particle size and composition and incident cardiovascular disease in a South-European population: The Hortega-Liposcale Follow-up Study. Int j cardiol 264:172–178PubMedCrossRef Pichler G, Amigo N, Tellez-Plaza M, Pardo-Cea M, Dominguez-Lucas A, Marrachelli V, Monleon D, Martin-Escudero JC, Ascaso J, Chaves F (2018) LDL particle size and composition and incident cardiovascular disease in a South-European population: The Hortega-Liposcale Follow-up Study. Int j cardiol 264:172–178PubMedCrossRef
27.
Zurück zum Zitat Thorning TK, Bertram HC, Bonjour J-P, De Groot L, Dupont D, Feeney E, Ipsen R, Lecerf JM, Mackie A, McKinley MC (2017) Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps. The Am j clin nutr 105(5):1033–1045PubMedCrossRef Thorning TK, Bertram HC, Bonjour J-P, De Groot L, Dupont D, Feeney E, Ipsen R, Lecerf JM, Mackie A, McKinley MC (2017) Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps. The Am j clin nutr 105(5):1033–1045PubMedCrossRef
28.
Zurück zum Zitat Astrup A (2014) Yogurt and dairy product consumption to prevent cardiometabolic diseases: epidemiologic and experimental studies. The Am j clin nutr 99(5):1235S–1242SPubMedCrossRef Astrup A (2014) Yogurt and dairy product consumption to prevent cardiometabolic diseases: epidemiologic and experimental studies. The Am j clin nutr 99(5):1235S–1242SPubMedCrossRef
29.
Zurück zum Zitat Guo J, Astrup A, Lovegrove JA, Gijsbers L, Givens DI, Soedamah-Muthu SS (2017) Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies. Springer Guo J, Astrup A, Lovegrove JA, Gijsbers L, Givens DI, Soedamah-Muthu SS (2017) Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies. Springer
30.
Zurück zum Zitat Abargouei AS, Janghorbani M, Salehi-Marzijarani M, Esmaillzadeh A (2012) Effect of dairy consumption on weight and body composition in adults: a systematic review and meta-analysis of randomized controlled clinical trials. Int j obes 36(12):1485–1493CrossRef Abargouei AS, Janghorbani M, Salehi-Marzijarani M, Esmaillzadeh A (2012) Effect of dairy consumption on weight and body composition in adults: a systematic review and meta-analysis of randomized controlled clinical trials. Int j obes 36(12):1485–1493CrossRef
31.
Zurück zum Zitat Morency M-E, Birken CS, Lebovic G, Chen Y, L’ Abbé M, Lee GJ, Maguire JL, Collaboration TK (2017) Association between noncow milk beverage consumption and childhood height. The Am j clin nutr 106 (2):597-602 Morency M-E, Birken CS, Lebovic G, Chen Y, L’ Abbé M, Lee GJ, Maguire JL, Collaboration TK (2017) Association between noncow milk beverage consumption and childhood height. The Am j clin nutr 106 (2):597-602
32.
Zurück zum Zitat Gui J-C, Brašić J, Liu X-D, Gong G-Y, Zhang G-M, Liu C-J, Gao G-Q (2012) Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow’s milk. Osteoporos Int 23(5):1563–1570PubMedCrossRef Gui J-C, Brašić J, Liu X-D, Gong G-Y, Zhang G-M, Liu C-J, Gao G-Q (2012) Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow’s milk. Osteoporos Int 23(5):1563–1570PubMedCrossRef
33.
Zurück zum Zitat Commission E (2013) Policy instruments for the dairy sector—milk and milk products. Official Journal of the European Union (L347/814) Commission E (2013) Policy instruments for the dairy sector—milk and milk products. Official Journal of the European Union (L347/814)
35.
Zurück zum Zitat Callaway J (2004) Hempseed as a nutritional resource: an overview. Euphytica 140(1–2):65–72CrossRef Callaway J (2004) Hempseed as a nutritional resource: an overview. Euphytica 140(1–2):65–72CrossRef
36.
Zurück zum Zitat Scholz-Ahrens KE, Ahrens F, Barth CA (2019) Nutritional and health attributes of milk and milk imitations. Eur j nutr:1–16 Scholz-Ahrens KE, Ahrens F, Barth CA (2019) Nutritional and health attributes of milk and milk imitations. Eur j nutr:1–16
37.
Zurück zum Zitat Gorissen SH, Crombag JJ, Senden JM, Waterval WH, Bierau J, Verdijk LB, van Loon LJ (2018) Protein content and amino acid composition of commercially available plant-based protein isolates. Amino acids 50(12):1685–1695PubMedPubMedCentralCrossRef Gorissen SH, Crombag JJ, Senden JM, Waterval WH, Bierau J, Verdijk LB, van Loon LJ (2018) Protein content and amino acid composition of commercially available plant-based protein isolates. Amino acids 50(12):1685–1695PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat Litmanovitz I, Davidson K, Eliakim A, Regev RH, Dolfin T, Arnon S, Bar-Yoseph F, Goren A, Lifshitz Y, Nemet D (2013) High beta-palmitate formula and bone strength in term infants: a randomized, double-blind, controlled trial. Calcif tissue int 92(1):35–41PubMedCrossRef Litmanovitz I, Davidson K, Eliakim A, Regev RH, Dolfin T, Arnon S, Bar-Yoseph F, Goren A, Lifshitz Y, Nemet D (2013) High beta-palmitate formula and bone strength in term infants: a randomized, double-blind, controlled trial. Calcif tissue int 92(1):35–41PubMedCrossRef
39.
Zurück zum Zitat Hoppe C, Mølgaard C, Juul A, Michaelsen K (2004) High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. Eur J Clin Nutr 58(9):1211–1216PubMedCrossRef Hoppe C, Mølgaard C, Juul A, Michaelsen K (2004) High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. Eur J Clin Nutr 58(9):1211–1216PubMedCrossRef
41.
Zurück zum Zitat Zhao Y, Martin BR, Weaver CM (2005) Calcium bioavailability of calcium carbonate fortified soymilk is equivalent to cow’s milk in young women. The J nutr 135(10):2379–2382PubMedCrossRef Zhao Y, Martin BR, Weaver CM (2005) Calcium bioavailability of calcium carbonate fortified soymilk is equivalent to cow’s milk in young women. The J nutr 135(10):2379–2382PubMedCrossRef
42.
Zurück zum Zitat Tang AL, Walker KZ, Wilcox G, Strauss BJ, Ashton JF, Stojanovska L (2010) Calcium absorption in Australian osteopenic postmenopausal women: an acute comparative study of fortified soymilk to cows. Asia Pac j clin nutr 19(2):243–249PubMed Tang AL, Walker KZ, Wilcox G, Strauss BJ, Ashton JF, Stojanovska L (2010) Calcium absorption in Australian osteopenic postmenopausal women: an acute comparative study of fortified soymilk to cows. Asia Pac j clin nutr 19(2):243–249PubMed
43.
Zurück zum Zitat Weaver CM, Janle E, Martin B, Browne S, Guiden H, Lachcik P, Lee WH (2009) Dairy versus calcium carbonate in promoting peak bone mass and bone maintenance during subsequent calcium deficiency. J Bone Miner Res 24(8):1411–1419PubMedCrossRef Weaver CM, Janle E, Martin B, Browne S, Guiden H, Lachcik P, Lee WH (2009) Dairy versus calcium carbonate in promoting peak bone mass and bone maintenance during subsequent calcium deficiency. J Bone Miner Res 24(8):1411–1419PubMedCrossRef
44.
Zurück zum Zitat Koletzko B, Goulet O, Hunt J, Krohn K, Shamir R, Group PNGW (2005) 1. Guidelines on paediatric parenteral nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR). J pediatr gastroenterol nutr 41:S1–S4PubMedCrossRef Koletzko B, Goulet O, Hunt J, Krohn K, Shamir R, Group PNGW (2005) 1. Guidelines on paediatric parenteral nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR). J pediatr gastroenterol nutr 41:S1–S4PubMedCrossRef
45.
Zurück zum Zitat Heaney RP (1991) Calcium intake in the osteoporotic fracture context: introduction. The Am j clin nutr 54(1):242S–244SPubMedCrossRef Heaney RP (1991) Calcium intake in the osteoporotic fracture context: introduction. The Am j clin nutr 54(1):242S–244SPubMedCrossRef
46.
Zurück zum Zitat Ellis D, Lieb J (2015) Hyperoxaluria and genitourinary disorders in children ingesting almond milk products. The Journal of pediatrics 167(5):1155–1158PubMedCrossRef Ellis D, Lieb J (2015) Hyperoxaluria and genitourinary disorders in children ingesting almond milk products. The Journal of pediatrics 167(5):1155–1158PubMedCrossRef
47.
Zurück zum Zitat Biver E, Durosier-Izart C, Merminod F, Chevalley T, van Rietbergen B, Ferrari SL, Rizzoli R (2018) Fermented dairy products consumption is associated with attenuated cortical bone loss independently of total calcium, protein, and energy intakes in healthy postmenopausal women. Osteoporos Int 29(8):1771–1782PubMedCrossRef Biver E, Durosier-Izart C, Merminod F, Chevalley T, van Rietbergen B, Ferrari SL, Rizzoli R (2018) Fermented dairy products consumption is associated with attenuated cortical bone loss independently of total calcium, protein, and energy intakes in healthy postmenopausal women. Osteoporos Int 29(8):1771–1782PubMedCrossRef
48.
Zurück zum Zitat Cheung ALTF, Wilcox G, Walker KZ, Shah NP, Strauss B, Ashton JF, Stojanovska L (2011) Fermentation of calcium-fortified soya milk does not appear to enhance acute calcium absorption in osteopenic post-menopausal women. Br j nutr 105(2):282–286PubMedCrossRef Cheung ALTF, Wilcox G, Walker KZ, Shah NP, Strauss B, Ashton JF, Stojanovska L (2011) Fermentation of calcium-fortified soya milk does not appear to enhance acute calcium absorption in osteopenic post-menopausal women. Br j nutr 105(2):282–286PubMedCrossRef
49.
Zurück zum Zitat Rizzoli R, Biver E (2018) Effects of fermented milk products on bone. Calcif tissue int 102(4):489–500PubMedCrossRef Rizzoli R, Biver E (2018) Effects of fermented milk products on bone. Calcif tissue int 102(4):489–500PubMedCrossRef
50.
Zurück zum Zitat Heaney RP, Rafferty K (2006) The settling problem in calcium-fortified soybean drinks. J Acad Nutr Diet 106(11):1753 Heaney RP, Rafferty K (2006) The settling problem in calcium-fortified soybean drinks. J Acad Nutr Diet 106(11):1753
51.
Zurück zum Zitat Klibanski A, Adams-Campbell L, Bassford TL, Blair SN, Boden SD, Dickersin K, Gifford DR, Glasse L, Goldring SR, Hruska K (2001) Osteoporosis prevention, diagnosis, and therapy. J Am Med Assoc 285(6):785–795CrossRef Klibanski A, Adams-Campbell L, Bassford TL, Blair SN, Boden SD, Dickersin K, Gifford DR, Glasse L, Goldring SR, Hruska K (2001) Osteoporosis prevention, diagnosis, and therapy. J Am Med Assoc 285(6):785–795CrossRef
52.
Zurück zum Zitat Laine CM, Laine T (2013) Diagnosis of osteoporosis in children and adolescents. European endocrinology 9(2):141–144PubMedPubMedCentral Laine CM, Laine T (2013) Diagnosis of osteoporosis in children and adolescents. European endocrinology 9(2):141–144PubMedPubMedCentral
53.
Zurück zum Zitat Hoppe C, Mølgaard C, Michaelsen KF (2006) Cow’s milk and linear growth in industrialized and developing countries. Annu Rev Nutr 26:131–173PubMedCrossRef Hoppe C, Mølgaard C, Michaelsen KF (2006) Cow’s milk and linear growth in industrialized and developing countries. Annu Rev Nutr 26:131–173PubMedCrossRef
54.
Zurück zum Zitat Bogin B (1998) Milk and human development: an essay on the “milk hypothesis”. Bogin B (1998) Milk and human development: an essay on the “milk hypothesis”.
56.
Zurück zum Zitat Dror DK, Allen LH (2014) Dairy product intake in children and adolescents in developed countries: trends, nutritional contribution, and a review of association with health outcomes. Nutr rev 72(2):68–81PubMedCrossRef Dror DK, Allen LH (2014) Dairy product intake in children and adolescents in developed countries: trends, nutritional contribution, and a review of association with health outcomes. Nutr rev 72(2):68–81PubMedCrossRef
57.
Zurück zum Zitat de Beer H (2012) Dairy products and physical stature: a systematic review and meta-analysis of controlled trials. Econo Hum Biol 10(3):299–309CrossRef de Beer H (2012) Dairy products and physical stature: a systematic review and meta-analysis of controlled trials. Econo Hum Biol 10(3):299–309CrossRef
58.
Zurück zum Zitat Kang K, Sotunde OF, Weiler HA (2019) Effects of milk and milk-product consumption on growth among children and adolescents aged 6–18 years: a meta-analysis of randomized controlled trials. Adv Nutr 10(2):250–261PubMedPubMedCentralCrossRef Kang K, Sotunde OF, Weiler HA (2019) Effects of milk and milk-product consumption on growth among children and adolescents aged 6–18 years: a meta-analysis of randomized controlled trials. Adv Nutr 10(2):250–261PubMedPubMedCentralCrossRef
59.
Zurück zum Zitat Dror D (2014) Dairy consumption and pre-school, school-age and adolescent obesity in developed countries: a systematic review and meta-analysis. Obes rev 15(6):516–527PubMedCrossRef Dror D (2014) Dairy consumption and pre-school, school-age and adolescent obesity in developed countries: a systematic review and meta-analysis. Obes rev 15(6):516–527PubMedCrossRef
60.
Zurück zum Zitat Günther AL, Remer T, Kroke A, Buyken AE (2007) Early protein intake and later obesity risk: which protein sources at which time points throughout infancy and childhood are important for body mass index and body fat percentage at 7 y of age? The Am j of clin nutr 86(6):1765–1772CrossRef Günther AL, Remer T, Kroke A, Buyken AE (2007) Early protein intake and later obesity risk: which protein sources at which time points throughout infancy and childhood are important for body mass index and body fat percentage at 7 y of age? The Am j of clin nutr 86(6):1765–1772CrossRef
61.
Zurück zum Zitat Hoppe C, Mølgaard C, Vaag A, Barkholt V, Michaelsen K (2005) High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys. Eur J Clin Nutr 59(3):393–398PubMedCrossRef Hoppe C, Mølgaard C, Vaag A, Barkholt V, Michaelsen K (2005) High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys. Eur J Clin Nutr 59(3):393–398PubMedCrossRef
62.
Zurück zum Zitat Hoppe C, Mølgaard C, Dalum C, Vaag A, Michaelsen KF (2009) Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys. Eur J Clin Nutr 63(9):1076–1083PubMedCrossRef Hoppe C, Mølgaard C, Dalum C, Vaag A, Michaelsen KF (2009) Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys. Eur J Clin Nutr 63(9):1076–1083PubMedCrossRef
63.
Zurück zum Zitat Goulding A, Cannan R, Williams S, Gold E, Taylor R, Lewis-Barned N (1998) Bone mineral density in girls with forearm fractures. J Bone Miner Res 13(1):143–148PubMedCrossRef Goulding A, Cannan R, Williams S, Gold E, Taylor R, Lewis-Barned N (1998) Bone mineral density in girls with forearm fractures. J Bone Miner Res 13(1):143–148PubMedCrossRef
64.
Zurück zum Zitat Goulding A, Jones I, Taylor R, Manning P, Williams S (2000) More broken bones: a 4-year double cohort study of young girls with and without distal forearm fractures. J Bone Miner Res 15(10):2011–2018PubMedCrossRef Goulding A, Jones I, Taylor R, Manning P, Williams S (2000) More broken bones: a 4-year double cohort study of young girls with and without distal forearm fractures. J Bone Miner Res 15(10):2011–2018PubMedCrossRef
65.
Zurück zum Zitat de Lamas C, de Castro MJ, Gil-Campos M, Gil Á, Couce ML, Leis R (2018) Effects of dairy product consumption on height and bone mineral content in children: a systematic review of controlled trials. Adv Nutr 10(suppl_2):S88–S96 de Lamas C, de Castro MJ, Gil-Campos M, Gil Á, Couce ML, Leis R (2018) Effects of dairy product consumption on height and bone mineral content in children: a systematic review of controlled trials. Adv Nutr 10(suppl_2):S88–S96
66.
Zurück zum Zitat van den Heuvel EG, Steijns JM (2018) Dairy products and bone health: how strong is the scientific evidence? Nutr res rev 31(2):164–178PubMedCrossRef van den Heuvel EG, Steijns JM (2018) Dairy products and bone health: how strong is the scientific evidence? Nutr res rev 31(2):164–178PubMedCrossRef
67.
Zurück zum Zitat Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A (2005) Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10–12-y-old girls: a 2-y randomized trial. The Am j clin nutr 82(5):1115–1126PubMedCrossRef Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A (2005) Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10–12-y-old girls: a 2-y randomized trial. The Am j clin nutr 82(5):1115–1126PubMedCrossRef
68.
Zurück zum Zitat Cadogan J, Eastell R, Jones N, Barker ME (1997) Milk intake and bone mineral acquisition in adolescent girls: randomised, controlled intervention trial. Bmj 315(7118):1255–1260PubMedPubMedCentralCrossRef Cadogan J, Eastell R, Jones N, Barker ME (1997) Milk intake and bone mineral acquisition in adolescent girls: randomised, controlled intervention trial. Bmj 315(7118):1255–1260PubMedPubMedCentralCrossRef
69.
Zurück zum Zitat Baran D, Sorensen A, Grimes J, Lew R, Karellas A, Johnson B, Roche J (1990) Dietary modification with dairy products for preventing vertebral bone loss in premenopausal women: a three-year prospective study. The J Clin Endocrinol Metab 70(1):264–270PubMedCrossRef Baran D, Sorensen A, Grimes J, Lew R, Karellas A, Johnson B, Roche J (1990) Dietary modification with dairy products for preventing vertebral bone loss in premenopausal women: a three-year prospective study. The J Clin Endocrinol Metab 70(1):264–270PubMedCrossRef
70.
Zurück zum Zitat Wadolowska L, Sobas K, Szczepanska J, Slowinska M, Czlapka-Matyasik M, Niedzwiedzka E (2013) Dairy products, dietary calcium and bone health: possibility of prevention of osteoporosis in women: the Polish experience. Nutrients 5(7):2684–2707PubMedPubMedCentralCrossRef Wadolowska L, Sobas K, Szczepanska J, Slowinska M, Czlapka-Matyasik M, Niedzwiedzka E (2013) Dairy products, dietary calcium and bone health: possibility of prevention of osteoporosis in women: the Polish experience. Nutrients 5(7):2684–2707PubMedPubMedCentralCrossRef
71.
Zurück zum Zitat Iguacel I, Miguel-Berges ML, Gómez-Bruton A, Moreno LA, Julián C (2018) Veganism, vegetarianism, bone mineral density, and fracture risk: a systematic review and meta-analysis. Nutr rev 77(1):1–18CrossRef Iguacel I, Miguel-Berges ML, Gómez-Bruton A, Moreno LA, Julián C (2018) Veganism, vegetarianism, bone mineral density, and fracture risk: a systematic review and meta-analysis. Nutr rev 77(1):1–18CrossRef
72.
Zurück zum Zitat Konstantynowicz J, Nguyen T, Kaczmarski M, Jamiolkowski J, Piotrowska-Jastrzebska J, Seeman E (2007) Fractures during growth: potential role of a milk-free diet. Osteoporos int 18(12):1601–1607PubMedCrossRef Konstantynowicz J, Nguyen T, Kaczmarski M, Jamiolkowski J, Piotrowska-Jastrzebska J, Seeman E (2007) Fractures during growth: potential role of a milk-free diet. Osteoporos int 18(12):1601–1607PubMedCrossRef
73.
Zurück zum Zitat Dagnelie PC, Vergote FJ, van Staveren WA, van den Berg H, Dingjan P, Hautvast J (1990) High prevalence of rickets in infants on macrobiotic diets. The Am j clin nutr 51(2):202–208PubMedCrossRef Dagnelie PC, Vergote FJ, van Staveren WA, van den Berg H, Dingjan P, Hautvast J (1990) High prevalence of rickets in infants on macrobiotic diets. The Am j clin nutr 51(2):202–208PubMedCrossRef
74.
Zurück zum Zitat Matía-Martín P, Torrego-Ellacuría M, Larrad-Sainz A, Fernández-Pérez C, Cuesta-Triana F, Rubio-Herrera MÁ (2018) Effects of milk and dairy products on the prevention of osteoporosis and osteoporotic fractures in Europeans and non-Hispanic Whites from North America: a systematic review and updated meta-analysis. Advances in Nutrition 10(suppl_2):S120–S143CrossRef Matía-Martín P, Torrego-Ellacuría M, Larrad-Sainz A, Fernández-Pérez C, Cuesta-Triana F, Rubio-Herrera MÁ (2018) Effects of milk and dairy products on the prevention of osteoporosis and osteoporotic fractures in Europeans and non-Hispanic Whites from North America: a systematic review and updated meta-analysis. Advances in Nutrition 10(suppl_2):S120–S143CrossRef
75.
Zurück zum Zitat Michaëlsson K, Wolk A, Langenskiöld S, Basu S, Lemming EW, Melhus H, Byberg L (2014) Milk intake and risk of mortality and fractures in women and men: cohort studies. Bmj 349:g6015PubMedPubMedCentralCrossRef Michaëlsson K, Wolk A, Langenskiöld S, Basu S, Lemming EW, Melhus H, Byberg L (2014) Milk intake and risk of mortality and fractures in women and men: cohort studies. Bmj 349:g6015PubMedPubMedCentralCrossRef
76.
Zurück zum Zitat Manios Y, Moschonis G, Trovas G, Lyritis GP (2007) Changes in biochemical indexes of bone metabolism and bone mineral density after a 12-mo dietary intervention program: the Postmenopausal Health Study. The Am j clin nutr 86(3):781–789PubMedCrossRef Manios Y, Moschonis G, Trovas G, Lyritis GP (2007) Changes in biochemical indexes of bone metabolism and bone mineral density after a 12-mo dietary intervention program: the Postmenopausal Health Study. The Am j clin nutr 86(3):781–789PubMedCrossRef
77.
Zurück zum Zitat Kanis JA, Oden A, McCloskey EV, Johansson H, Wahl DA, Cooper C (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos int 23(9):2239–2256PubMedPubMedCentralCrossRef Kanis JA, Oden A, McCloskey EV, Johansson H, Wahl DA, Cooper C (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos int 23(9):2239–2256PubMedPubMedCentralCrossRef
78.
Zurück zum Zitat Balk E, Adam G, Langberg V, Earley A, Clark P, Ebeling P, Mithal A, Rizzoli R, Zerbini C, Pierroz D (2017) Global dietary calcium intake among adults: a systematic review. Osteoporos Int 28(12):3315–3324PubMedPubMedCentralCrossRef Balk E, Adam G, Langberg V, Earley A, Clark P, Ebeling P, Mithal A, Rizzoli R, Zerbini C, Pierroz D (2017) Global dietary calcium intake among adults: a systematic review. Osteoporos Int 28(12):3315–3324PubMedPubMedCentralCrossRef
79.
Zurück zum Zitat Whitton C, Nicholson SK, Roberts C, Prynne CJ, Pot GK, Olson A, Fitt E, Cole D, Teucher B, Bates B (2011) National Diet and Nutrition Survey: UK food consumption and nutrient intakes from the first year of the rolling programme and comparisons with previous surveys. Br j nutr 106(12):1899–1914PubMedPubMedCentralCrossRef Whitton C, Nicholson SK, Roberts C, Prynne CJ, Pot GK, Olson A, Fitt E, Cole D, Teucher B, Bates B (2011) National Diet and Nutrition Survey: UK food consumption and nutrient intakes from the first year of the rolling programme and comparisons with previous surveys. Br j nutr 106(12):1899–1914PubMedPubMedCentralCrossRef
80.
Zurück zum Zitat Pedersen AN, Christensen T, Matthiessen J, Knudsen VK, Sørensen MR, Biltoft-Jensen AP, Hinsch H-J, Ygil KH, Kørup K, Saxholt E (2015) Danskernes kostvaner 2011–2013. Danmarks Tekniske Universitet, DTU Fødevareinstituttet Pedersen AN, Christensen T, Matthiessen J, Knudsen VK, Sørensen MR, Biltoft-Jensen AP, Hinsch H-J, Ygil KH, Kørup K, Saxholt E (2015) Danskernes kostvaner 2011–2013. Danmarks Tekniske Universitet, DTU Fødevareinstituttet
81.
Zurück zum Zitat Feskanich D, Meyer H, Fung T, Bischoff-Ferrari H, Willett W (2018) Milk and other dairy foods and risk of hip fracture in men and women. Osteoporos Int 29(2):385–396PubMedCrossRef Feskanich D, Meyer H, Fung T, Bischoff-Ferrari H, Willett W (2018) Milk and other dairy foods and risk of hip fracture in men and women. Osteoporos Int 29(2):385–396PubMedCrossRef
82.
Zurück zum Zitat Tagliaferri C, Wittrant Y, Davicco M-J, Walrand S, Coxam V (2015) Muscle and bone, two interconnected tissues. Ageing res rev 21:55–70PubMedCrossRef Tagliaferri C, Wittrant Y, Davicco M-J, Walrand S, Coxam V (2015) Muscle and bone, two interconnected tissues. Ageing res rev 21:55–70PubMedCrossRef
83.
Zurück zum Zitat Li G, Zhang L, Wang D, AIQudsy L, Jiang JX, Xu H, Shang P (2019) Muscle-bone crosstalk and potential therapies for sarco-osteoporosis. J cell biochem Li G, Zhang L, Wang D, AIQudsy L, Jiang JX, Xu H, Shang P (2019) Muscle-bone crosstalk and potential therapies for sarco-osteoporosis. J cell biochem
84.
Zurück zum Zitat Reginster J-Y, Beaudart C, Buckinx F, Bruyère O (2016) Osteoporosis and sarcopenia: two diseases or one? Curr opin clin nutr metab care 19(1):31–36PubMedCrossRef Reginster J-Y, Beaudart C, Buckinx F, Bruyère O (2016) Osteoporosis and sarcopenia: two diseases or one? Curr opin clin nutr metab care 19(1):31–36PubMedCrossRef
85.
Zurück zum Zitat Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA, Phillips SM (2009) Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. The Am j clin nutr 89(1):161–168PubMedCrossRef Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA, Phillips SM (2009) Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. The Am j clin nutr 89(1):161–168PubMedCrossRef
86.
Zurück zum Zitat Groen BB, Horstman AM, Hamer HM, De Haan M, Van Kranenburg J, Bierau J, Poeze M, Wodzig WK, Rasmussen BB, Van Loon LJ (2015) Post-prandial protein handling: you are what you just ate. PLoS One 10(11):e0141582PubMedPubMedCentralCrossRef Groen BB, Horstman AM, Hamer HM, De Haan M, Van Kranenburg J, Bierau J, Poeze M, Wodzig WK, Rasmussen BB, Van Loon LJ (2015) Post-prandial protein handling: you are what you just ate. PLoS One 10(11):e0141582PubMedPubMedCentralCrossRef
87.
Zurück zum Zitat Koopman R, Crombach N, Gijsen AP, Walrand S, Fauquant J, Kies AK, Lemosquet S, Saris WH, Boirie Y, van Loon LJ (2009) Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. The Am j clin nutr 90(1):106–115PubMedCrossRef Koopman R, Crombach N, Gijsen AP, Walrand S, Fauquant J, Kies AK, Lemosquet S, Saris WH, Boirie Y, van Loon LJ (2009) Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. The Am j clin nutr 90(1):106–115PubMedCrossRef
88.
Zurück zum Zitat Pennings B, Boirie Y, Senden JM, Gijsen AP, Kuipers H, van Loon LJ (2011) Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. The Am j clin nutr 93(5):997–1005PubMedCrossRef Pennings B, Boirie Y, Senden JM, Gijsen AP, Kuipers H, van Loon LJ (2011) Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. The Am j clin nutr 93(5):997–1005PubMedCrossRef
89.
Zurück zum Zitat Burd NA, Gorissen SH, Van Vliet S, Snijders T, Van Loon LJ (2015) Differences in postprandial protein handling after beef compared with milk ingestion during postexercise recovery: a randomized controlled trial. The Am j clin nutr 102(4):828–836PubMedCrossRef Burd NA, Gorissen SH, Van Vliet S, Snijders T, Van Loon LJ (2015) Differences in postprandial protein handling after beef compared with milk ingestion during postexercise recovery: a randomized controlled trial. The Am j clin nutr 102(4):828–836PubMedCrossRef
90.
Zurück zum Zitat Hamer HM, Wall BT, Kiskini A, de Lange A, Groen BB, Bakker JA, Gijsen AP, Verdijk LB, van Loon LJ (2013) Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men. Nutr metab 10(1):15CrossRef Hamer HM, Wall BT, Kiskini A, de Lange A, Groen BB, Bakker JA, Gijsen AP, Verdijk LB, van Loon LJ (2013) Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men. Nutr metab 10(1):15CrossRef
91.
Zurück zum Zitat Gorissen SH, Burd NA, Hamer HM, Gijsen AP, Groen BB, Van Loon LJ (2014) Carbohydrate coingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion. The J Clin Endocrinol Metab 99(6):2250–2258PubMedCrossRef Gorissen SH, Burd NA, Hamer HM, Gijsen AP, Groen BB, Van Loon LJ (2014) Carbohydrate coingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion. The J Clin Endocrinol Metab 99(6):2250–2258PubMedCrossRef
92.
Zurück zum Zitat Gorissen SH, Burd NA, Kramer IF, van Kranenburg J, Gijsen AP, Rooyackers O, van Loon LJ (2017) Co-ingesting milk fat with micellar casein does not affect postprandial protein handling in healthy older men. Clin nutr 36(2):429–437PubMedCrossRef Gorissen SH, Burd NA, Kramer IF, van Kranenburg J, Gijsen AP, Rooyackers O, van Loon LJ (2017) Co-ingesting milk fat with micellar casein does not affect postprandial protein handling in healthy older men. Clin nutr 36(2):429–437PubMedCrossRef
93.
Zurück zum Zitat van Vliet S, Burd NA, van Loon LJ (2015) The skeletal muscle anabolic response to plant-versus animal-based protein consumption. The J nutr 145(9):1981–1991PubMedCrossRef van Vliet S, Burd NA, van Loon LJ (2015) The skeletal muscle anabolic response to plant-versus animal-based protein consumption. The J nutr 145(9):1981–1991PubMedCrossRef
94.
Zurück zum Zitat Wall BT, Hamer HM, de Lange A, Kiskini A, Groen BB, Senden JM, Gijsen AP, Verdijk LB, van Loon LJ (2013) Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men. Clin nutr 32(3):412–419PubMedCrossRef Wall BT, Hamer HM, de Lange A, Kiskini A, Groen BB, Senden JM, Gijsen AP, Verdijk LB, van Loon LJ (2013) Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men. Clin nutr 32(3):412–419PubMedCrossRef
95.
Zurück zum Zitat Wall BT, Dirks ML, Van Loon LJ (2013) Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia. Ageing res rev 12(4):898–906PubMedCrossRef Wall BT, Dirks ML, Van Loon LJ (2013) Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia. Ageing res rev 12(4):898–906PubMedCrossRef
96.
Zurück zum Zitat Jacobs DR Jr, Pereira MA, Meyer KA, Kushi LH (2000) Fiber from whole grains, but not refined grains, is inversely associated with all-cause mortality in older women: the Iowa women’s health study. Journal of the American College of Nutrition 19(sup3):326S–330SPubMedCrossRef Jacobs DR Jr, Pereira MA, Meyer KA, Kushi LH (2000) Fiber from whole grains, but not refined grains, is inversely associated with all-cause mortality in older women: the Iowa women’s health study. Journal of the American College of Nutrition 19(sup3):326S–330SPubMedCrossRef
97.
Zurück zum Zitat Bolton RP, Heaton KW, Burroughs LF (1981) The role of dietary fiber in satiety, glucose, and insulin: studies with fruit and fruit juice. The Am j clin nutr 34(2):211–217PubMedCrossRef Bolton RP, Heaton KW, Burroughs LF (1981) The role of dietary fiber in satiety, glucose, and insulin: studies with fruit and fruit juice. The Am j clin nutr 34(2):211–217PubMedCrossRef
99.
Zurück zum Zitat Vishwanathan R, Goodrow-Kotyla EF, Wooten BR, Wilson TA, Nicolosi RJ (2009) Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins. The Am j clin nutr 90(5):1272–1279PubMedCrossRef Vishwanathan R, Goodrow-Kotyla EF, Wooten BR, Wilson TA, Nicolosi RJ (2009) Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins. The Am j clin nutr 90(5):1272–1279PubMedCrossRef
100.
101.
102.
Zurück zum Zitat Howell TJ, MacDougall DE, Jones PJ (1998) Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding. J lipid res 39(4):892–900PubMed Howell TJ, MacDougall DE, Jones PJ (1998) Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding. J lipid res 39(4):892–900PubMed
103.
Zurück zum Zitat Barceló-Coblijn G, Murphy EJ, Othman R, Moghadasian MH, Kashour T, Friel JK (2008) Flaxseed oil and fish-oil capsule consumption alters human red blood cell n–3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n–3 fatty acid. The Am J Clin Nutr 88(3):801–809. https://doi.org/10.1093/ajcn/88.3.801 CrossRefPubMed Barceló-Coblijn G, Murphy EJ, Othman R, Moghadasian MH, Kashour T, Friel JK (2008) Flaxseed oil and fish-oil capsule consumption alters human red blood cell n–3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n–3 fatty acid. The Am J Clin Nutr 88(3):801–809. https://​doi.​org/​10.​1093/​ajcn/​88.​3.​801 CrossRefPubMed
104.
Zurück zum Zitat Lopez-Garcia E, Hagan KA, Fung TT, Hu FB, Rodríguez-Artalejo F (2018) Mediterranean diet and risk of frailty syndrome among women with type 2 diabetes. The Am j clin nutr 107(5):763–771PubMedCrossRef Lopez-Garcia E, Hagan KA, Fung TT, Hu FB, Rodríguez-Artalejo F (2018) Mediterranean diet and risk of frailty syndrome among women with type 2 diabetes. The Am j clin nutr 107(5):763–771PubMedCrossRef
105.
Zurück zum Zitat Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, Ringel A, Davis JM, Hibbeln JR (2013) Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. Bmj 346:e8707PubMedPubMedCentralCrossRef Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, Ringel A, Davis JM, Hibbeln JR (2013) Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. Bmj 346:e8707PubMedPubMedCentralCrossRef
106.
Zurück zum Zitat Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR (2016) Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). bmj 353:i1246PubMedPubMedCentralCrossRef Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR (2016) Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). bmj 353:i1246PubMedPubMedCentralCrossRef
107.
Zurück zum Zitat Foster GD, Shantz KL, Vander Veur SS, Oliver TL, Lent MR, Virus A, Szapary PO, Rader DJ, Zemel BS, Gilden-Tsai A (2012) A randomized trial of the effects of an almond-enriched, hypocaloric diet in the treatment of obesity. The Am j clin nutr 96(2):249–254PubMedCrossRef Foster GD, Shantz KL, Vander Veur SS, Oliver TL, Lent MR, Virus A, Szapary PO, Rader DJ, Zemel BS, Gilden-Tsai A (2012) A randomized trial of the effects of an almond-enriched, hypocaloric diet in the treatment of obesity. The Am j clin nutr 96(2):249–254PubMedCrossRef
108.
Zurück zum Zitat Praagman J, Beulens JW, Alssema M, Zock PL, Wanders AJ, Sluijs I, Van Der Schouw YT (2016) The association between dietary saturated fatty acids and ischemic heart disease depends on the type and source of fatty acid in the European Prospective Investigation into Cancer and Nutrition–Netherlands cohort, 2. The Am j clin nutr 103(2):356–365PubMedCrossRef Praagman J, Beulens JW, Alssema M, Zock PL, Wanders AJ, Sluijs I, Van Der Schouw YT (2016) The association between dietary saturated fatty acids and ischemic heart disease depends on the type and source of fatty acid in the European Prospective Investigation into Cancer and Nutrition–Netherlands cohort, 2. The Am j clin nutr 103(2):356–365PubMedCrossRef
109.
Zurück zum Zitat Alonso A, Nettleton JA, Ix JH, de Boer IH, Folsom AR, Bidulescu A, Kestenbaum BR, Chambless LE, Jacobs DR Jr (2010) Dietary phosphorus, blood pressure, and incidence of hypertension in the atherosclerosis risk in communities study and the multi-ethnic study of atherosclerosis. Hypertension 55(3):776–784PubMedCrossRef Alonso A, Nettleton JA, Ix JH, de Boer IH, Folsom AR, Bidulescu A, Kestenbaum BR, Chambless LE, Jacobs DR Jr (2010) Dietary phosphorus, blood pressure, and incidence of hypertension in the atherosclerosis risk in communities study and the multi-ethnic study of atherosclerosis. Hypertension 55(3):776–784PubMedCrossRef
110.
Zurück zum Zitat Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, Reid IR (2010) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. Bmj 341:c3691PubMedPubMedCentralCrossRef Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, Reid IR (2010) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. Bmj 341:c3691PubMedPubMedCentralCrossRef
111.
Zurück zum Zitat Faghih S, Abadi A, Hedayati M, Kimiagar S (2011) Comparison of the effects of cows’ milk, fortified soy milk, and calcium supplement on weight and fat loss in premenopausal overweight and obese women. Nutr Metab Cardiovasc Dis 21(7):499–503PubMedCrossRef Faghih S, Abadi A, Hedayati M, Kimiagar S (2011) Comparison of the effects of cows’ milk, fortified soy milk, and calcium supplement on weight and fat loss in premenopausal overweight and obese women. Nutr Metab Cardiovasc Dis 21(7):499–503PubMedCrossRef
112.
Zurück zum Zitat Ostlund RE Jr, Racette SB, Stenson WF (2002) Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. Nutri rev 60(11):349–359CrossRef Ostlund RE Jr, Racette SB, Stenson WF (2002) Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. Nutri rev 60(11):349–359CrossRef
113.
Zurück zum Zitat Poneros-Schneier A, Erdman J Jr (1989) Bioavailability of calcium from sesame seeds, almond powder, whole wheat bread, spinach and nonfat dry milk in rats. J food sci 54(1):150–153CrossRef Poneros-Schneier A, Erdman J Jr (1989) Bioavailability of calcium from sesame seeds, almond powder, whole wheat bread, spinach and nonfat dry milk in rats. J food sci 54(1):150–153CrossRef
Metadaten
Titel
Impact of whole dairy matrix on musculoskeletal health and aging–current knowledge and research gaps
verfasst von
N.R.W. Geiker
C. Mølgaard
S. Iuliano
R. Rizzoli
Y. Manios
L.J.C. van Loon
J.-M. Lecerf
G. Moschonis
J.-Y. Reginster
I. Givens
A. Astrup
Publikationsdatum
14.11.2019
Verlag
Springer London
Erschienen in
Osteoporosis International / Ausgabe 4/2020
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-019-05229-7

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