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Erschienen in: Experimental Brain Research 1/2010

01.07.2010 | Research Article

Reduced heart rate variability predicts poor sleep quality in a case–control study of chronic fatigue syndrome

verfasst von: A. R. Burton, K. Rahman, Y. Kadota, A. Lloyd, U. Vollmer-Conna

Erschienen in: Experimental Brain Research | Ausgabe 1/2010

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Abstract

Parasympathetic function is important in the induction and maintenance of sleep. We examined whether nocturnal vagal modulation of heart rate is related to the poor sleep quality commonly reported in chronic fatigue syndrome (CFS). Heart rate (HR, as R–R intervals) was continuously monitored during sleep in 20 patients with CFS and 20 matched control subjects. Questionnaires assessed demographic information, symptoms, functional impairment, and subjective sleep quality. CFS was associated with more sleep problems in general and poorer subjective sleep quality on the study night (all p < 0.003), and reports of repeated awakening during the night were 7 times more likely compared to healthy subjects (p = 0.017). Time and frequency-domain parameters of HR variability during sleep were significantly lower in patients with CFS (all p < 0.006). Multiple regression analyses revealed that heart rate variability (HRV) parameters were the best predictors of subjective sleep measures. This study identified significant reductions in vagal modulation of heart rate during sleep in CFS. Low HRV strongly predicted sleep quality—suggesting a pervasive state of nocturnal sympathetic hypervigilance in CFS.
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Metadaten
Titel
Reduced heart rate variability predicts poor sleep quality in a case–control study of chronic fatigue syndrome
verfasst von
A. R. Burton
K. Rahman
Y. Kadota
A. Lloyd
U. Vollmer-Conna
Publikationsdatum
01.07.2010
Verlag
Springer-Verlag
Erschienen in
Experimental Brain Research / Ausgabe 1/2010
Print ISSN: 0014-4819
Elektronische ISSN: 1432-1106
DOI
https://doi.org/10.1007/s00221-010-2296-1

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