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Erschienen in: Calcified Tissue International 2/2003

01.08.2003 | Clinical Investigations

Alendronate Treatment in Men With Primary Osteoporosis: A Three-Year Longitudinal Study

verfasst von: S. Gonnelli, C. Cepollaro, A. Montagnani, D. Bruni, C. Caffarelli, M. Breschi, L. Gennari, C. Gennari, R. Nuti

Erschienen in: Calcified Tissue International | Ausgabe 2/2003

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Abstract

Bisphosphonates have been widely used in the treatment of osteoporosis in women, whereas until now there have been few data on their use in men. The aim of this study was to evaluate the effect of a 3-year alendronate treatment on bone mineral density (BMD) and quantitative ultrasound (QUS) in men with primary osteoporosis. We studied 77 osteoporotic men (aged 57.1 ± 10.8 yrs) who completed a 3-year treatment with alendronate (10 mg/day) plus calcium (1000 mg/day) (n = 39), or calcium alone (n = 38). At baseline and at a 12-month interval, we measured BMD at the lumbar spine and femur (femoral neck and total hip) by DXA (Hologic) and speed of sound (SOS), broadband ultrasound attenuation (BUA) and Stiffness (S) at the os calcis by Achilles plus (Lunar). Alendronate treatment had significantly increased lumbar spine BMD by 4.2% at year 1, by 6.3% at year 2, and 8.8% at year 3. BMD at the femoral neck and total hip had increased by 2.1% and 1.6% at year 1, by 3.2% and 2.9% at year 2, and by 4.2% and 3.9% at year 3, respectively. BUA and Stiffness showed a significant increase in the alendronate-treated group at year 2 (3.2% and 4.9%, respectively) and at year 3 (3.8% and 6%, respectively). BMD at the lumbar spine showed the best longitudinal sensitivity whereas longitudinal sensitivity of both QUS at the heel and femur BMD were similar. In conclusion, this study confirms that alendronate represents an important therapeutic advance in the management of male osteoporosis. BMD at the lumbar spine appears to be the best method for monitoring the effect of alendronate on bone mass in osteoporotic men.
Literatur
1.
Zurück zum Zitat Melton III, LJ 2001The prevalence of osteoporosis: gender and racial comparison.Calcif Tissue Int69179181CrossRefPubMed Melton III, LJ 2001The prevalence of osteoporosis: gender and racial comparison.Calcif Tissue Int69179181CrossRefPubMed
2.
Zurück zum Zitat Seeman, E 1999Osteoporosis in men.Osteoporos Int (suppl)2S97S110 Seeman, E 1999Osteoporosis in men.Osteoporos Int (suppl)2S97S110
3.
Zurück zum Zitat Cooper, C, Campion, G, Melton III, LJ 1992Hip fractures in the elderly: a world-wide projection.Osteoporos Int2285289PubMed Cooper, C, Campion, G, Melton III, LJ 1992Hip fractures in the elderly: a world-wide projection.Osteoporos Int2285289PubMed
4.
Zurück zum Zitat Orwoll, ES 1998Osteoporosis in men.Osteoporos Int27349367 Orwoll, ES 1998Osteoporosis in men.Osteoporos Int27349367
5.
Zurück zum Zitat O’Neill, TW, Felsenberg, D, Varlow, J, Cooper, C, Kanis, JA, Silman, AJ 1996The prevalence of vertebral deformity in European men and women: The European Vertebral Osteoporosis Study.J Bone Miner Res1110101018PubMed O’Neill, TW, Felsenberg, D, Varlow, J, Cooper, C, Kanis, JA, Silman, AJ 1996The prevalence of vertebral deformity in European men and women: The European Vertebral Osteoporosis Study.J Bone Miner Res1110101018PubMed
6.
Zurück zum Zitat Center, JR, Nguyen, TV, Schneider, D, Sambrook, PN, Eisman, JA 1999Mortality after all major types of osteoporotic fracture in men and women: an observational study.Lancet353878882PubMed Center, JR, Nguyen, TV, Schneider, D, Sambrook, PN, Eisman, JA 1999Mortality after all major types of osteoporotic fracture in men and women: an observational study.Lancet353878882PubMed
7.
Zurück zum Zitat Katznelson, L, Finkelstein, JS, Schoenfeld, DA, Rosenthal, DI, Anderson, EJ, Klibanski, A 1996Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism.J Clin Endocrinol Metab124358 Katznelson, L, Finkelstein, JS, Schoenfeld, DA, Rosenthal, DI, Anderson, EJ, Klibanski, A 1996Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism.J Clin Endocrinol Metab124358
8.
Zurück zum Zitat Snyder, PJ, Peachey, H, Berlin, JA, Hannoush, P, Hadda, G, Dlewati, A, Santanna, J, Loh, I, Lenrow, DA, Olmes, JH, Kapoor, SC, Atkinson, LE, Strom, BL 1999Effect of testosterone replacement in hypogonadal men.J Clin Endocrinol Metab8419661972PubMed Snyder, PJ, Peachey, H, Berlin, JA, Hannoush, P, Hadda, G, Dlewati, A, Santanna, J, Loh, I, Lenrow, DA, Olmes, JH, Kapoor, SC, Atkinson, LE, Strom, BL 1999Effect of testosterone replacement in hypogonadal men.J Clin Endocrinol Metab8419661972PubMed
9.
Zurück zum Zitat Orwoll, E, Ettinger, M, Weiss, S, Miller, P, Kendler, D, Graham, J, Adami, S, Weber, K, Lorene, R, Pietschmann, P, Vandormacl, K, Lombardi, A 2000Alendronate for the treatment of osteoporosis in men.N Engl J Med343604610PubMed Orwoll, E, Ettinger, M, Weiss, S, Miller, P, Kendler, D, Graham, J, Adami, S, Weber, K, Lorene, R, Pietschmann, P, Vandormacl, K, Lombardi, A 2000Alendronate for the treatment of osteoporosis in men.N Engl J Med343604610PubMed
10.
Zurück zum Zitat Ho, YV, Frauman, AG, Thomson, W, Seeman, E 2000Effects of alendronate on bone density in men with primary and secondary osteoporosis.Osteoporos Int1198101PubMed Ho, YV, Frauman, AG, Thomson, W, Seeman, E 2000Effects of alendronate on bone density in men with primary and secondary osteoporosis.Osteoporos Int1198101PubMed
11.
Zurück zum Zitat Ringe, JD, Faber, H, Dorst, A 2001Alendronate treatment of established primary osteoporosis in men: results of a two-year prospective study.J Clin Endocrinol Metab8652525255PubMed Ringe, JD, Faber, H, Dorst, A 2001Alendronate treatment of established primary osteoporosis in men: results of a two-year prospective study.J Clin Endocrinol Metab8652525255PubMed
12.
Zurück zum Zitat Weber, T, Drezner, M 2001Effect of alendronate on bone mineral density in male idiopathic osteoporosis.Metabolism50912915CrossRefPubMed Weber, T, Drezner, M 2001Effect of alendronate on bone mineral density in male idiopathic osteoporosis.Metabolism50912915CrossRefPubMed
13.
Zurück zum Zitat Liberman, UA, Weiss, SR, Broll, J, Minnie, HW, Quan, H, Bell, NH, Rodriguez-Portales, J, Downs Jr, RW, Dequecker, J, Favus, M 1995Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis.N Engl J Med33314371443PubMed Liberman, UA, Weiss, SR, Broll, J, Minnie, HW, Quan, H, Bell, NH, Rodriguez-Portales, J, Downs Jr, RW, Dequecker, J, Favus, M 1995Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis.N Engl J Med33314371443PubMed
14.
Zurück zum Zitat Black, DM, Cummings, SR, Karpf, DB, Cauley, JA, Thompson, DE, Nevitt, MC, Bauer, DC, Genant, HK, Haskell, WL, Marcus, R, Ott, SM, Torner, JC, Quandt, SA, Reiss, TF, Ensrud, KE 1996Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures.Lancet34815351541for the Fracture Intervention Trial Research GroupPubMed Black, DM, Cummings, SR, Karpf, DB, Cauley, JA, Thompson, DE, Nevitt, MC, Bauer, DC, Genant, HK, Haskell, WL, Marcus, R, Ott, SM, Torner, JC, Quandt, SA, Reiss, TF, Ensrud, KE 1996Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures.Lancet34815351541for the Fracture Intervention Trial Research GroupPubMed
15.
Zurück zum Zitat Cortet, B, Dubois, P, Boutry, N, Palos, G, Cotton, A, Marchandise, X 2002Computed tomography image analysis of the calcaneous in male osteoporosis.Osteoporos Int133341CrossRef Cortet, B, Dubois, P, Boutry, N, Palos, G, Cotton, A, Marchandise, X 2002Computed tomography image analysis of the calcaneous in male osteoporosis.Osteoporos Int133341CrossRef
16.
Zurück zum Zitat Legrand, E, Chappard, D, Pascaretti, C, Duquenne, M, Rondeau, C, Simon, Y, Rohmer, V, Basle, M.F., Audran, M 1999Bone mineral density and vertebral fractures in men.Osteoporos Int10265270CrossRefPubMed Legrand, E, Chappard, D, Pascaretti, C, Duquenne, M, Rondeau, C, Simon, Y, Rohmer, V, Basle, M.F., Audran, M 1999Bone mineral density and vertebral fractures in men.Osteoporos Int10265270CrossRefPubMed
17.
Zurück zum Zitat Gluer, CC 1997Quantitative ultrasound techniques for the assessment of osteoporosis: expert agreement on current status.J Bone Miner Res1212801288for the International Quantitative Ultrasound Consensus GroupPubMed Gluer, CC 1997Quantitative ultrasound techniques for the assessment of osteoporosis: expert agreement on current status.J Bone Miner Res1212801288for the International Quantitative Ultrasound Consensus GroupPubMed
18.
Zurück zum Zitat Gluer, CC, Wu, CY, Jergas, M, Goldstein, SA, Genant, HK 1994Three quantitative ultrasound parameters reflect bone structure.Calcif Tissue Int554652PubMed Gluer, CC, Wu, CY, Jergas, M, Goldstein, SA, Genant, HK 1994Three quantitative ultrasound parameters reflect bone structure.Calcif Tissue Int554652PubMed
19.
Zurück zum Zitat Njeh, CF, Fuerst, T, Diessel, E, Genant, HK 2001Is quantitative ultrasound dependent on bone structure? A reflection.Osteoporos Int12115CrossRefPubMed Njeh, CF, Fuerst, T, Diessel, E, Genant, HK 2001Is quantitative ultrasound dependent on bone structure? A reflection.Osteoporos Int12115CrossRefPubMed
20.
Zurück zum Zitat Hans, D, Dargent-Molina, P, Schott, AM, Sebert, JL, Cormier, C, Kotzki, PO, Delmas, PD, Pouilles, JM, Breart, G, Meunier, PG 1996Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study.Lancet348511514for the EPIDOS prospective study groupPubMed Hans, D, Dargent-Molina, P, Schott, AM, Sebert, JL, Cormier, C, Kotzki, PO, Delmas, PD, Pouilles, JM, Breart, G, Meunier, PG 1996Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study.Lancet348511514for the EPIDOS prospective study groupPubMed
21.
Zurück zum Zitat Bauer, DC, Gluer, CC, Cauley, JA, Vogt, TM, Ensrud, KE, Genant, HK, Blake, DM 1997Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women.Arch Intern Med157629634for the study of osteoporotic fractures research groupPubMed Bauer, DC, Gluer, CC, Cauley, JA, Vogt, TM, Ensrud, KE, Genant, HK, Blake, DM 1997Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women.Arch Intern Med157629634for the study of osteoporotic fractures research groupPubMed
22.
Zurück zum Zitat Sahota, O, San, P, Cawte, SA, Pearson, D, Hosking, DJ 2000A comparison of the longitudinal changes in quantitative ultrasound with dual-energy X-ray absorptiometry: the four-year effects of hormone replacement therapy.Osteoporos Int115258CrossRefPubMed Sahota, O, San, P, Cawte, SA, Pearson, D, Hosking, DJ 2000A comparison of the longitudinal changes in quantitative ultrasound with dual-energy X-ray absorptiometry: the four-year effects of hormone replacement therapy.Osteoporos Int115258CrossRefPubMed
23.
Zurück zum Zitat Gonnelli, S, Cepollaro, C, Montagnani, A, Martini, S, Gennari, L, Mangeri, M, Gennari, C 2002Heel ultrasonography in monitoring alendronate therapy: a four-year longitudinal study.Osteoporos Int13415421CrossRef Gonnelli, S, Cepollaro, C, Montagnani, A, Martini, S, Gennari, L, Mangeri, M, Gennari, C 2002Heel ultrasonography in monitoring alendronate therapy: a four-year longitudinal study.Osteoporos Int13415421CrossRef
24.
Zurück zum Zitat Krieg, MA, Jacquet, AF, Bremgartner, M, Cuttelod, S, Thiebaud, D, Burckardt, P 1999Effect of supplementation with vitamin D3 and calcium on quantitative ultrasound of bone in elderly institutionalized women: a longitudinal study.Osteoporos Int9483488CrossRefPubMed Krieg, MA, Jacquet, AF, Bremgartner, M, Cuttelod, S, Thiebaud, D, Burckardt, P 1999Effect of supplementation with vitamin D3 and calcium on quantitative ultrasound of bone in elderly institutionalized women: a longitudinal study.Osteoporos Int9483488CrossRefPubMed
25.
Zurück zum Zitat Pluskiewicz, W, Drozdzowska, B 1999Ultrasound measurements at the calcaneus in men: differences between healthy and fractured persons and the influence of age and anthropometric features on ultrasound parameters.Osteoporos Int104751CrossRefPubMed Pluskiewicz, W, Drozdzowska, B 1999Ultrasound measurements at the calcaneus in men: differences between healthy and fractured persons and the influence of age and anthropometric features on ultrasound parameters.Osteoporos Int104751CrossRefPubMed
26.
Zurück zum Zitat Adler, RA, Funkhouser, HL, Holt, CM 2001Utility of heel ultrasound bone density in men.J Clin Densitom3225230 Adler, RA, Funkhouser, HL, Holt, CM 2001Utility of heel ultrasound bone density in men.J Clin Densitom3225230
27.
Zurück zum Zitat Montagnani, A, Gonnelli, S, Cepollaro, C, Mangeri, M, Monaco, R, Gennari, L, Gennari, C 2001Usefulness of bone quantitative ultrasound in management of osteoporosis in men.J Clin Densitom3231237 Montagnani, A, Gonnelli, S, Cepollaro, C, Mangeri, M, Monaco, R, Gennari, L, Gennari, C 2001Usefulness of bone quantitative ultrasound in management of osteoporosis in men.J Clin Densitom3231237
28.
Zurück zum Zitat Mulleman, D, Legroux-Gerot, I, Duquesnoy, B, Marchandies, X, Delcambre, B, Cortet, B 2002Quantitative ultrasound in bone male osteoporosis.Osteoporos Int13388393CrossRef Mulleman, D, Legroux-Gerot, I, Duquesnoy, B, Marchandies, X, Delcambre, B, Cortet, B 2002Quantitative ultrasound in bone male osteoporosis.Osteoporos Int13388393CrossRef
29.
Zurück zum Zitat Gluer, CC 1999Monitoring skeletal changes by radiological techniques.J Bone Miner Res1419521962PubMed Gluer, CC 1999Monitoring skeletal changes by radiological techniques.J Bone Miner Res1419521962PubMed
30.
Zurück zum Zitat Tucci, JR, Tonino, RP, Emkey, RD, Peverly, CA, Kher, U, Santora II, AC 1996Effect of three years of oral alendronate treatment in postmenopausal women with osteoporosis.Am J Med101488501for the U.S. Alendronate Phase III Osteoporosis Treatment Study GroupCrossRefPubMed Tucci, JR, Tonino, RP, Emkey, RD, Peverly, CA, Kher, U, Santora II, AC 1996Effect of three years of oral alendronate treatment in postmenopausal women with osteoporosis.Am J Med101488501for the U.S. Alendronate Phase III Osteoporosis Treatment Study GroupCrossRefPubMed
31.
Zurück zum Zitat Parfitt, AM 1980Morphologic basis of bone mineral measurements: transient and steady state effects of treatment in osteoporosis.Miner Electrolyte Metab4273287 Parfitt, AM 1980Morphologic basis of bone mineral measurements: transient and steady state effects of treatment in osteoporosis.Miner Electrolyte Metab4273287
32.
Zurück zum Zitat Hanson, J 1997Standardization of femur BMD (letter).J Bone Miner Res1213161317PubMed Hanson, J 1997Standardization of femur BMD (letter).J Bone Miner Res1213161317PubMed
33.
Zurück zum Zitat Patel, R, Blake, GM, Rymer, J, Fogelman, I 2000Long-term precision of DXA scanning assessed over seven years in forty postmenopausal women.Osteoporos Int116875CrossRefPubMed Patel, R, Blake, GM, Rymer, J, Fogelman, I 2000Long-term precision of DXA scanning assessed over seven years in forty postmenopausal women.Osteoporos Int116875CrossRefPubMed
Metadaten
Titel
Alendronate Treatment in Men With Primary Osteoporosis: A Three-Year Longitudinal Study
verfasst von
S. Gonnelli
C. Cepollaro
A. Montagnani
D. Bruni
C. Caffarelli
M. Breschi
L. Gennari
C. Gennari
R. Nuti
Publikationsdatum
01.08.2003
Erschienen in
Calcified Tissue International / Ausgabe 2/2003
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-002-1085-7

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