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Calcified Tissue International

Erschienen in:

01.09.2015 | Review

Effects of Collagen Crosslinking on Bone Material Properties in Health and Disease

verfasst von: Mitsuru Saito, Keishi Marumo

Erschienen in: Calcified Tissue International | Ausgabe 3/2015

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Abstract

Data have accumulated to show that various types of collagen crosslinking are implicated in the health of individuals, as well as in a number of disease states, such as osteoporosis, diabetes mellitus, chronic kidney disease, inflammatory bowel disease, or in conditions of mild hyperhomocysteinemia, or when glucocorticoid use is indicated. Collagen crosslinking is a posttranslational modification of collagen molecules and plays important roles in tissue differentiation and in the mechanical properties of collagenous tissue. The crosslinking of collagen in the body can form via two mechanisms: one is enzymatic crosslinking and the other is nonenzymatic crosslinking. Lysyl hydroxylases and lysyl oxidases regulate tissue-specific crosslinking patterns and quantities. Enzymatic crosslinks initially form via immature divalent crosslinking, and a portion of them convert into mature trivalent forms such as pyridinoline and pyrrole crosslinks. Nonenzymatic crosslinks form as a result of reactions which create advanced glycation end products (AGEs), such as pentosidine and glucosepane. These types of crosslinks differ in terms of their mechanisms of formation and function. Impaired enzymatic crosslinking and/or an increase of AGEs have been proposed as a major cause of bone fragility associated with aging and numerous disease states. This review focuses on the effects of collagen crosslinking on bone material properties in health and disease.

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Titel: Effects of Collagen Crosslinking on Bone Material Properties in Health and Disease
verfasst von: Mitsuru Saito
Keishi Marumo
Publikationsdatum: 01.09.2015
Verlag: Springer US
Erschienen in: Calcified Tissue International / Ausgabe 3/2015
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-015-9985-5

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Effects of Collagen Crosslinking on Bone Material Properties in Health and Disease

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