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Impact of long-term benzodiazepine use on cognitive functioning in young adults: the VISAT cohort

  • Pharmacoepidemiology and Prescription
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Abstract

Purpose

Results from a number of studies have suggested a relationship between cognitive alteration and benzodiazepine use in the elderly. The aim of this study was to determine the impact of benzodiazepine use on cognitive functions in a young adult population.

Methods

This study included 1,019 French salaried workers from the VISAT (Aging, Health and Work) cohort whose objective was to determine the long-term impact of working conditions on health and aging. Data were collected during interviews by occupational physicians in 1996, 2001 and 2006. Cognitive function was assessed using five cognitive tests (immediate free recall test, delayed free recall test, recognition test, Digit Symbol Substitution Subtest and visual search speed test). Cognitive scores obtained after a 10-year follow-up were investigated among three categories of benzodiazepine users, namely, non-users, occasional users and long-term users, using analysis of covariance models adjusted for several potential confounders in men and women separately.

Results

In the course of the 10 year-follow-up, 3.9% of subjects were defined as occasional users of benzodiazepine and 7.5% as long-term users. The analysis revealed a significant alteration of long-term memory in women whereas there was no significant association in men.

Conclusions

Long-term use of benzodiazepine leads to specific impairment in long-term memory only in women.

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Acknowledgments

This study has received support from the French Research Agency (ANR: Agence Nationale de la Recherche) and the French Medicine Agency (MILDT: Mission Interministérielle de la Lutte contre la Drogue et la Toxicomanie).

Conflict of interest statement

The authors declare that they have no conflicts of interest regarding the content of this article.

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Authors and Affiliations

  1. U1027 INSERM Pharmacoepidemiology Unit, Faculty of Medicine, University of Toulouse, 37, allées Jules Guesde, 31000, Toulouse, France

    Olivia Boeuf-Cazou & Maryse Lapeyre-Mestre

  2. Centre technique d’appui et de formation des centres d’examens de santé (CETAF), Saint-Etienne, France

    Bienvenu Bongue

  3. International University of Monaco, Monte Carlo, Monaco

    David Ansiau

  4. UMR 5263 CNRS Laboratoire Travail et Cognition (CLLE), University of Toulouse, Toulouse, France

    Jean-Claude Marquié

Authors
  1. Olivia Boeuf-Cazou
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  2. Bienvenu Bongue
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  4. Jean-Claude Marquié
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  5. Maryse Lapeyre-Mestre
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Correspondence to Olivia Boeuf-Cazou.

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Boeuf-Cazou, O., Bongue, B., Ansiau, D. et al. Impact of long-term benzodiazepine use on cognitive functioning in young adults: the VISAT cohort. Eur J Clin Pharmacol 67, 1045–1052 (2011). https://doi.org/10.1007/s00228-011-1047-y

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  • DOI: https://doi.org/10.1007/s00228-011-1047-y

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