nach oben

Neuroradiology

Erschienen in:

01.02.2006 | Diagnostic Neuroradiology

Imaging features of copper deficiency myelopathy: a study of 25 cases

verfasst von: Neeraj Kumar, J. Eric Ahlskog, Christopher J. Klein, John D. Port

Erschienen in: Neuroradiology | Ausgabe 2/2006

Einloggen, um Zugang zu erhalten

Abstract

Acquired copper deficiency presents with a spastic gait and sensory ataxia. Spinal cord magnetic resonance imaging (MRI) in patients with copper deficiency myelopathy may show increased T2 signal, most commonly in the dorsal midline cervical and thoracic cord. These imaging findings may be reversible with normalization of serum copper. The clinical and imaging picture is very similar to the subacute combined degeneration seen in patients with vitamin B12 deficiency. Neuroradiologists should consider this possibility when a long segment of symmetric dorsal spinal cord T2-hyperintensity is identified.

Bottomley SS (2004) Sideroblastic anemias. In: Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskevas F, Glader B (eds) Wintrobe's clinical hematology, 11th edn. Lippincott, Philadelphia, pp 1011–1033

Schleper B, Stuerenburg HJ (2001) Copper deficiency-associated myelopathy in a 46-year-old woman. J Neurol 248:705–706PubMedCrossRef

Gregg XT, Reddy V, Prchal JT (2002) Copper deficiency masquerading as myelodysplastic syndrome. Blood 100:1493–1495PubMedCrossRef

Prodan CI, Holland NR, Wisdom PJ, Burstein SA, Bottomley SS (2002) CNS demyelination associated with copper deficiency and hyperzincemia. Neurology 59:1453–1456PubMedCrossRef

Kumar N, Gross JB Jr, Ahlskog JE (2003) Myelopathy due to copper deficiency. Neurology 61:273PubMed

Hedera P, Fink JK, Bockenstedt PL, Brewer GJ (2003) Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin: further support for existence of a new zinc overload syndrome. Arch Neurol 60:1303–1306PubMedCrossRef

Kumar N, McEvoy KM, Ahlskog JE (2003) Myelopathy due to copper deficiency following gastrointestinal surgery. Arch Neurol 60:1782–1785PubMedCrossRef

Greenberg SA, Briemberg HR (2004) A neurological and hematological syndrome associated with zinc excess and copper deficiency. J Neurol 251:111–114PubMedCrossRef

Kumar N, Crum B, Petersen RC, Vernino S, Ahlskog JE (2004) Copper deficiency myelopathy. Arch Neurol 61:762–766PubMedCrossRef

10.

Kumar N, Low PA (2004) Myeloneuropathy and anemia due to copper malabsorption. J Neurol 251:747–749PubMedCrossRef

11.

Kumar N, Gross JB, Ahlskog JE (2004) Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. Neurology 63:33–39PubMed

12.

Kumar N, Ahlskog EA, Gross JB (2004) Acquired hypocupremia after gastric surgery. Clin Gastroenterol Hepatol 2:1074–1079PubMedCrossRef

13.

Jubb KVF, Huxtable CR (1993) The nervous system. In: Jubb KVF, Kennedy PC, Palmer N (eds) Pathology of domestic animals, 4th edn. Academic Press, San Diego, pp 267–439

14.

Tan N, Urich H (1983) Menkes' Disease and Swayback—a comparative study of two copper deficiency syndromes. J Neurol Sci 62:95–113PubMedCrossRef

15.

Penrith ML, Tustin RC, Thornton DJ, Burdett PD (1996) Swayback in a blesbok (Damaliscus dorcas phillipsi) and a black wildebeest (Connochaetes gnou). J S Afr Vet Assoc 67:93–96PubMed

16.

Barlow RM (1963) Further observations on swayback, Part 1 (Transitional pathology). J Comp Pathol 73:51–60PubMed

17.

Alleyne T, Joseph J, Lalla A, Sampson V, Adogwa A (1998) Cytochrome-c oxidase isolated from the brain of swayback-diseased sheep display unusual structure and uncharacteristic kinetics. Mol Chem Neuropathol 34:233–247PubMedCrossRef

18.

Kumar N, Ahlskog JE (2004) Myeloneuropathy due to copper deficiency or zinc excess? (letter) Arch Neurol 61:604–605PubMedCrossRef

19.

Hedera P, Brewer GJ (2004) Myeloneuropathy due to copper deficiency or zinc excess? Arch Neurol 61:605 (letter)CrossRef

20.

Katsaros VK, Glocker FX, Hemmer B, Schumacher M (1998) MRI of spinal cord and brain lesions in subacute combined degeneration. Neuroradiology 40:716–719PubMedCrossRef

21.

Locatelli ER, Laureno R, Ballard P, Mark AS (1999) MRI in vitamin B12 deficiency myelopathy. Can J Neurol Sci 26:60–63PubMed

22.

Misra UK, Kalita J, Das A (2003) Vitamin B12 deficiency neurological syndromes: a clinical, MRI and electrodiagnostic study. Electromyogr Clin Neurophysiol 43:57–64PubMed

23.

Larner AJ, Zeman AZ, Allen CM, Antoun NM (1997) MRI appearances in subacute combined degeneration of the spinal cord due to vitamin B12 deficiency. J Neurol Neurosurg Psychiatry 62:99–100PubMedCrossRef

24.

Beltramello A, Puppini G, Cerini R, El-Dalati G, Manfredi M, Roncolato G et al (1998) Subacute combined degeneration of the spinal cord after nitrous oxide anaesthesia: role of magnetic resonance imaging. J Neurol Neurosurg Psychiatry 64:563–564PubMed

25.

Wolansky LJ, Goldstein G, Gozo A, Lee HJ, Sills I, Chatkupt S (1995) Subacute combined degeneration of the spinal cord: MRI detection of preferential involvement of the posterior columns in a child. Pediatr Radiol 25:140–141PubMedCrossRef

26.

Kuker W, Hesselmann V, Thron A, de Simone A (1997) MRI demonstration of reversible impairment of the blood-CNS barrier function in subacute combined degeneration of the spinal cord. J Neurol Neurosurg Psychiatry 62:298–299PubMed

27.

Karantanas AH, Markonis A, Bisbiyiannis G (2000) Subacute combined degeneration of the spinal cord with involvement of the anterior columns: a new MRI finding. Neuroradiology 42:115–117PubMedCrossRef

28.

Berger JR, Quencer R (1991) Reversible myelopathy with pernicious anemia: clinical/MR correlation. Neurology 41:947–948PubMed

29.

Tajima Y, Mito Y, Owada Y, Moriwaka F, Tashiro K (1994) MR appearance of subacute combined degeneration of the spinal cord. Jpn J Psychiatry Neurol 48:611–614PubMed

30.

Bassi SS, Bulundwe KK, Greeff GP, Labuscagne JH, Gledhill RF (1999) MRI of the spinal cord in myelopathy complicating vitamin B12 deficiency: two additional cases and a review of the literature. Neuroradiology 41:271–274PubMedCrossRef

31.

Sobue G, Yasuda T, Kumazawa K, Yamamoto K, Mitsuma T (1995) MRI demonstrates dorsal column involvement of the spinal cord in Sjogren's syndrome-associated neuropathy. Neurology 45:592–593PubMed

32.

Yasuda T, Sobue G, Hirose Y, Mimura M, Yanagi T (1994) MR of acute autonomic and sensory neuropathy. Am J Neuroradiol 15:114–115PubMed

33.

Kieburtz KD, Giang DW, Schiffer RB, Vakil N (1991) Abnormal vitamin B12 metabolism in human immunodeficiency virus infection. Association with neurological dysfunction. Arch Neurol 48:312–314PubMed

34.

Konagaya M, Matsumoto A, Takase S, Mizutani T, Sobue G, Konishi T et al (2004) Clinical analysis of longstanding subacute myelo-optico-neuropathy: sequelae of clioquinol at 32 years after its ban. J Neurol Sci 218:85–90PubMedCrossRef

Titel: Imaging features of copper deficiency myelopathy: a study of 25 cases
verfasst von: Neeraj Kumar
J. Eric Ahlskog
Christopher J. Klein
John D. Port
Publikationsdatum: 01.02.2006
Verlag: Springer-Verlag
Erschienen in: Neuroradiology / Ausgabe 2/2006
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-005-0016-5

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

22.04.2024 | DGIM 2024 | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Imaging features of copper deficiency myelopathy: a study of 25 cases

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Update Neurologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2006

Predicting memory performance in normal ageing using different measures of hippocampal size

Imaging characteristics of toxoplasmosis encephalitis after bone marrow transplantation: report of two cases and review of the literature

Diffusion-weighted magnetic resonance imaging in carotid angioplasty and stenting with balloon embolic protection devices

The association between neurological deficit in acute ischemic stroke and mean transit time

M. Filippi, G. Comi, M. Rovaris (eds): Normal-appearing white and grey matter damage in multiple sclerosis

European Society of Neuroradiology (ESNR)

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Update Neurologie