nach oben

Erschienen in:

01.04.2010 | Diagnostic Neuroradiology

Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging

verfasst von: Hanna Järnum, Elena G. Steffensen, Linda Knutsson, Ernst-Torben Fründ, Carsten Wiberg Simonsen, Søren Lundbye-Christensen, Ajit Shankaranarayanan, David C. Alsop, Finn Taagehøj Jensen, Elna-Marie Larsson

Erschienen in: Neuroradiology | Ausgabe 4/2010

Einloggen, um Zugang zu erhalten

Abstract

Introduction

The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours.

Methods

A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter > 2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum.

Results

There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p = 0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p = 0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82.

Conclusion

PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed.

Ohgaki H, Kleihues P (2005) Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 64:479–489PubMed

Tourdias T, Rodrigo S, Oppenheim C et al (2008) Pulsed arterial spin labeling applications in brain tumors: practical review. J Neuroradiol 35:79–89CrossRefPubMed

Zhang H, Rodiger LA, Shen T, Miao J, Oudkerk M (2008) Preoperative subtyping of meningiomas by perfusion MR imaging. Neuroradiology 50:835–840CrossRefPubMed

Jenkinson MD, Smith TS, Joyce KA et al (2006) Cerebral blood volume, genotype and chemosensitivity in oligodendroglial tumours. Neuroradiology 48:703–713CrossRefPubMed

Zonari P, Baraldi P, Crisi G (2007) Multimodal MRI in the characterization of glial neoplasms: the combined role of single-voxel MR spectroscopy, diffusion imaging and echo-planar perfusion imaging. Neuroradiology 49:795–803CrossRefPubMed

Hakyemez B, Erdogan C, Ercan I, Ergin N, Uysal S, Atahan S (2005) High-grade and low-grade gliomas: differentiation by using perfusion MR imaging. Clin Radiol 60:493–502CrossRefPubMed

Shin JH, Lee HK, Kwun BD et al (2002) Using relative cerebral blood flow and volume to evaluate the histopathologic grade of cerebral gliomas: preliminary results. AJR Am J Roentgenol 179:783–789PubMed

Wolf RL, Detre JA (2007) Clinical neuroimaging using arterial spin-labeled perfusion magnetic resonance imaging. Neurotherapeutics 4:346–359CrossRefPubMed

Petersen ET, Zimine I, Ho YC, Golay X (2006) Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques. Br J Radiol 79:688–701CrossRefPubMed

10.

Kimura H, Takeuchi H, Koshimoto Y et al (2006) Perfusion imaging of meningioma by using continuous arterial spin-labeling: comparison with dynamic susceptibility-weighted contrast-enhanced MR images and histopathologic features. AJNR Am J Neuroradiol 27:85–93PubMed

11.

Warmuth C, Gunther M, Zimmer C (2003) Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging. Radiology 228:523–532CrossRefPubMed

12.

Weber MA, Thilmann C, Lichy MP et al (2004) Assessment of irradiated brain metastases by means of arterial spin-labeling and dynamic susceptibility-weighted contrast-enhanced perfusion MRI: initial results. Invest Radiol 39:277–287CrossRefPubMed

13.

Kim HS, Kim SY (2007) A prospective study on the added value of pulsed arterial spin-labeling and apparent diffusion coefficients in the grading of gliomas. AJNR Am J Neuroradiol 28:1693–1699CrossRefPubMed

14.

Essig M, Wenz F, Scholdei R et al (2002) Dynamic susceptibility contrast-enhanced echo-planar imaging of cerebral gliomas. Effect of contrast medium extravasation. Acta Radiol 43:354–359CrossRefPubMed

15.

Ostergaard L, Weisskoff RM, Chesler DA, Gyldensted C, Rosen BR (1996) High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: mathematical approach and statistical analysis. Magn Reson Med 36:715–725CrossRefPubMed

16.

Rosen BR, Belliveau JW, Vevea JM, Brady TJ (1990) Perfusion imaging with NMR contrast agents. Magn Reson Med 14:249–265CrossRefPubMed

17.

Boxerman JL, Schmainda KM, Weisskoff RM (2006) Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. AJNR Am J Neuroradiol 27:859–867PubMed

18.

Dai W, Garcia D, de Bazelaire C, Alsop DC (2008) Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields. Magn Reson Med 60:1488–1497CrossRefPubMed

19.

Alsop DC, Detre JA (1996) Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J Cereb Blood Flow Metab 16:1236–1249CrossRefPubMed

20.

Wang J, Zhang Y, Wolf RL, Roc AC, Alsop DC, Detre JA (2005) Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility study. Radiology 235:218–228CrossRefPubMed

21.

Lu H, Clingman C, Golay X, van Zijl PC (2004) Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla. Magn Reson Med 52:679–682CrossRefPubMed

22.

Herscovitch P, Raichle ME (1985) What is the correct value for the brain–blood partition coefficient for water? J Cereb Blood Flow Metab 5:65–69PubMed

23.

Garcia DM, Duhamel G, Alsop DC (2005) Efficiency of inversion pulses for background suppressed arterial spin labeling. Magn Reson Med 54:366–372CrossRefPubMed

24.

Emblem KE, Nedregaard B, Nome T et al (2008) Glioma grading by using histogram analysis of blood volume heterogeneity from MR-derived cerebral blood volume maps. Radiology 247:808–817CrossRefPubMed

25.

Bland JM, Altman DG (1999) Measuring agreement in method comparison studies. Stat Methods Med Res 8:135–160CrossRefPubMed

26.

Appignani B, Wong ET, Hackney DB, Alsop DC (2006) Comparison of arterial spin labeling and dynamic susceptibility contrast imaging in glioma. Proc Intl Soc Mag Reson Med 14

27.

Wang J, Alsop DC, Li L et al (2002) Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla. Magn Reson Med 48:242–254CrossRefPubMed

28.

Ye FQ, Berman KF, Ellmore T et al (2000) H(2)(15)O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans. Magn Reson Med 44:450–456CrossRefPubMed

29.

Arbab AS, Aoki S, Toyama K et al (2001) Brain perfusion measured by flow-sensitive alternating inversion recovery (FAIR) and dynamic susceptibility contrast-enhanced magnetic resonance imaging: comparison with nuclear medicine technique. Eur Radiol 11:635–641CrossRefPubMed

30.

Carvalho PA, Schwartz RB, Alexander E 3rd et al (1992) Detection of recurrent gliomas with quantitative thallium-201/technetium-99 m HMPAO single-photon emission computerized tomography. J Neurosurg 77:565–570CrossRefPubMed

31.

Ulmer S, Helle M, Jansen O, Mehdorn HM, Nabavi A (2009) Intraoperative dynamic susceptibility contrast weighted magnetic resonance imaging (iDSC-MRI)—technical considerations and feasibility. Neuroimage 45:38–43CrossRefPubMed

32.

Chawla S, Wang S, Wolf RL et al (2007) Arterial spin-labeling and MR spectroscopy in the differentiation of gliomas. AJNR Am J Neuroradiol 28:1683–1689CrossRefPubMed

33.

Senturk S, Oguz KK, Cila A (2009) Dynamic contrast-enhanced susceptibility-weighted perfusion imaging of intracranial tumors: a study using a 3 T MR scanner. Diagn Interv Radiol 15:3–12PubMed

34.

Knutsson L, van Westen D, Petersen ET et al (2009) Absolute quantification of cerebral blood flow: correlation between dynamic susceptibility contrast MRI and model-free arterial spin labeling. Magn Reson Imaging, doi:10.1016/j.mri.2009.06.006

35.

Petersen ET, Mouridsen K, Golay X, on behalf of all named co-authors of the QUASAR test–retest study (2009) The QUASAR reproducibility study, part II: results from a multi-center arterial spin labeling test–retest study. Neuroimage, doi:10.1016/j.neuroimage.2009.07.068

36.

Andersen C (1997) In vivo estimation of water content in cerebral white matter of brain tumour patients and normal individuals: towards a quantitative brain oedema definition. Acta Neurochir (Wien) 139:249–255 discussion 255–6CrossRef

37.

Nagesh V, Tsien CI, Chenevert TL et al (2008) Radiation-induced changes in normal-appearing white matter in patients with cerebral tumors: a diffusion tensor imaging study. Int J Radiat Oncol Biol Phys 70:1002–1010PubMed

38.

Leenders KL, Perani D, Lammertsma AA et al (1990) Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain 113(Pt 1):27–47CrossRefPubMed

39.

van Gelderen P, de Zwart JA, Duyn JH (2008) Pittfalls of MRI measurement of white matter perfusion based on arterial spin labeling. Magn Reson Med 59:788–795CrossRefPubMed

40.

Paulson ES, Schmainda KM (2008) Comparison of dynamic susceptibility-weighted contrast-enhanced MR methods: recommendations for measuring relative cerebral blood volume in brain tumors. Radiology 249:601–613CrossRefPubMed

41.

Zhang H, Rodiger LA, Shen T, Miao J, Oudkerk M (2008) Perfusion MR imaging for differentiation of benign and malignant meningiomas. Neuroradiology 50:525–530CrossRefPubMed

42.

Weber MA, Zoubaa S, Schlieter M et al (2006) Diagnostic performance of spectroscopic and perfusion MRI for distinction of brain tumors. Neurology 66:1899–1906CrossRefPubMed

43.

Wolf RL, Wang J, Wang S et al (2005) Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla. J Magn Reson Imaging 22:475–482CrossRefPubMed

44.

Ludemann L, Grieger W, Wurm R, Budzisch M, Hamm B, Zimmer C (2001) Comparison of dynamic contrast-enhanced MRI with WHO tumor grading for gliomas. Eur Radiol 11:1231–1241CrossRefPubMed

45.

Weber MA, Gunther M, Lichy MP et al (2003) Comparison of arterial spin-labeling techniques and dynamic susceptibility-weighted contrast-enhanced MRI in perfusion imaging of normal brain tissue. Invest Radiol 38:712–718CrossRefPubMed

46.

Young R, Babb J, Law M, Pollack E, Johnson G (2007) Comparison of region-of-interest analysis with three different histogram analysis methods in the determination of perfusion metrics in patients with brain gliomas. J Magn Reson Imaging 26:1053–1063CrossRefPubMed

Titel: Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging
verfasst von: Hanna Järnum
Elena G. Steffensen
Linda Knutsson
Ernst-Torben Fründ
Carsten Wiberg Simonsen
Søren Lundbye-Christensen
Ajit Shankaranarayanan
David C. Alsop
Finn Taagehøj Jensen
Elna-Marie Larsson
Publikationsdatum: 01.04.2010
Verlag: Springer-Verlag
Erschienen in: Neuroradiology / Ausgabe 4/2010
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-009-0616-6

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

25.04.2024 | Hypotonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging

Abstract

Introduction

Methods

Results

Conclusion

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Update Neurologie

Springer Medizin

Abstract

Introduction

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2010

Altered carotid plaque signal among different repetition times on T1-weighted magnetic resonance plaque imaging with self-navigated radial-scan technique

MR plaque imaging of the carotid artery

Magnetic resonance plaque imaging to predict the occurrence of the slow-flow phenomenon in carotid artery stenting procedures

Distinction between glioma progression and post-radiation change by combined physiologic MR imaging

Reviewers January 2009–December 2009

C-arm flat detector computed tomography: the technique and its applications in interventional neuro-radiology

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Update Neurologie