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Erschienen in: Neuroradiology 2/2016

01.02.2016 | Diagnostic Neuroradiology

Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings

verfasst von: Kenji Ito, Masako Kudo, Makoto Sasaki, Ayumi Saito, Fumio Yamashita, Taisuke Harada, Suguru Yokosawa, Ikuko Uwano, Hiroyuki Kameda, Yasuo Terayama

Erschienen in: Neuroradiology | Ausgabe 2/2016

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Abstract

Introduction

The periaqueductal gray matter (PAG) is considered to play an important role in generating migraine, but findings from imaging studies remain unclear. Therefore, we investigated whether diffusion kurtosis imaging (DKI) can detect changes in the PAG of migraine patients.

Methods

We obtained source images for DKI from 20 patients with episodic migraine and 20 healthy controls using a 3 T magnetic resonance imaging scanner. Mean kurtosis (MK), fractional anisotropy (FA), and mean diffusivity (MD) maps were generated, and the values of the PAG and other deep gray and white matter structures were automatically measured using an atlas-based region-of-interest analysis. The metrics of these structures were compared between the patients and controls.

Results

The MK and MD values of the PAG were significantly increased in the migraine patients compared with the controls (p < 0.05). The FA values were not significantly different. There were no significant differences in the metrics of the other structures between the patients and controls. The MK values of the PAG were significantly positively correlated with both age and the untreated period in the patient group under univariate analysis (r = 0.53 and 0.56, respectively; p < 0.05) but not multivariate analysis.

Conclusions

DKI detected significant increases in the MK and MD values of the PAG in patients with migraine, which suggests that structural changes in the PAG are associated with the pathophysiological mechanisms of migraine.
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Metadaten
Titel
Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings
verfasst von
Kenji Ito
Masako Kudo
Makoto Sasaki
Ayumi Saito
Fumio Yamashita
Taisuke Harada
Suguru Yokosawa
Ikuko Uwano
Hiroyuki Kameda
Yasuo Terayama
Publikationsdatum
01.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Neuroradiology / Ausgabe 2/2016
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-015-1603-8

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