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Erschienen in: Pediatric Radiology 9/2003

01.09.2003 | Original Article

Coincidence FDG-PET in the evaluation of Langerhans' cell histiocytosis: preliminary findings

verfasst von: Larry A. Binkovitz, Randal S. Olshefski, Brent H. Adler

Erschienen in: Pediatric Radiology | Ausgabe 9/2003

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Abstract

Background

Bone involvement in Langerhans' cell histiocytosis (LCH) is common. Both bone scintigraphy and plain films are used to identify osseous lesions, but lack specificity for disease activity and response to therapy. FDG-PET is a sensitive technique for identifying bone lesions when histiocytes are present.

Objective

To describe the potential of coincidence FDG-PET (cFDG-PET) for identification of active bone lesions in LCH and to determine whether it can provide more specific information regarding lesional response to therapy than bone scintigraphy or radiography.

Materials and methods

The clinical data and imaging findings of three patients with osseous lesions of LCH were retrospectively reviewed.

Results

cFDG-PET identified all active LCH osseous lesions in these patients, differentiated active from healed lesions, and demonstrated normalization of uptake in a treated lesion earlier than bone scintigraphy and radiography.

Conclusion

cFDG-PET appears to have greater specificity than bone scintigraphy and radiography for the identification of active osseous lesions in LCH. It also may predict response to treatment earlier than conventional techniques. Its use in the evaluation of LCH warrants further study.
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Metadaten
Titel
Coincidence FDG-PET in the evaluation of Langerhans' cell histiocytosis: preliminary findings
verfasst von
Larry A. Binkovitz
Randal S. Olshefski
Brent H. Adler
Publikationsdatum
01.09.2003
Verlag
Springer-Verlag
Erschienen in
Pediatric Radiology / Ausgabe 9/2003
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-003-0943-4

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