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Pediatric Radiology

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01.04.2004 | Review

Extra-osseous involvement of Langerhans’ cell histiocytosis in children

verfasst von: Sabine Schmidt, Georg Eich, Sylviane Hanquinet, Heinz Tschäppeler, Peter Waibel, François Gudinchet

Erschienen in: Pediatric Radiology | Ausgabe 4/2004

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Abstract

The predominant clinical and radiological features of Langerhans’ cell histiocytosis (LCH) in children are due to osseous involvement. Extra-osseous disease is far less common, occurring in association with bone disease or in isolation; nearly all anatomical sites may be affected and in very various combinations. The following article is based on a multicentre review of 31 children with extra-osseous LCH. The objective is to summarise the diverse possibilities of organ involvement. The radiological manifestations using different imaging modalities are rarely pathognomonic on their own. Nevertheless, familiarity with the imaging findings, especially in children with systemic disease, may be essential for early diagnosis.

Nicholson HS, Egeler PM, Nexbit ME (1998) The epidemiology of Langerhans’ cell histiocytosis. Hematol Oncol Clin North Am 12:379–383PubMed

Favara BE, Feller AC, Pauli M, et al (1997) Contemporary classification of histiocytic disorders. Med Pediatr Oncol 29:157–166CrossRefPubMed

Langerhans P (1868) Ueber die Nerven der menschlichen Haut. Virchows Arch (Pathol Anat) 44:325–337

Devay KO, Putzi MJ (1997) Clinicopathological consultation—head and neck Langerhans’ cell histiocytosis. Ann Otol Rhinol Laryngol 106:526–532PubMed

Egeler RM, D’Angio GJ (1995) Langerhans’ cell histiocytosis. J Pediatr 127:1–10PubMed

Nezelof C, Basset F (1998) Langerhans’ cell histiocytosis research. Hematol Oncol Clin North Am 12:385–406PubMed

Birbeck W, Breathnach AS, Everall JD (1961) An electron microscopic study of basal melanocytes and high-level clear cells (Langerhans’ cells) in vitiligo. J Invest Dermatol 37:51–60

Auerswald U, Barth J, Magnussen H (1991) Value of CD-1-positive cells in bronchoalveolar lavage fluid for the diagnosis of pulmonary histiocytosis X. Lungs 169:305–309

Réfabert L, Rambaud C, Mamou-Mani T, et al (1996) Cd1a-positive cells in bronchoalveolar lavage samples from children with Langerhans’ cell histiocytosis. J Pediatr 129:913–915PubMed

10.

Kilpatrick SE, Wenger DE, Gilchrist GS, et al (1995) Langerhans’ cell histiocytosis of bone. Cancer 76:2471–2484PubMed

11.

Yousem SA, Colby TV, Chen YY, et al (2001) Pulmonary Langerhans’ cell histiocytosis: molecular analysis of clonality. Am J Surg Pathol 25:630–636CrossRefPubMed

12.

Howarth DM, Glichrist GS, Mullan BP, et al (1999) Langerhans’ cell histiocytosis. Diagnosis, natural history, management, and outcome. Cancer 85:2278–2290CrossRefPubMed

13.

Broadbent V, Egeler RM, Nesbit ME Jr (1994) Langerhans’ Cell histiocytosis: clinical and epidemiological aspects. Br J Cancer 70[Suppl XXIII]:S11–S16

14.

Chu T, D’Angio GJ, Favara B, et al (1987) Histiocytosis syndromes in children: by the writing group of the Histiocyte Society. Lancet 1:208–209PubMed

15.

Damry N, Hottat N, Azzi N, et al (2000) Unusual findings in two cases of Langerhans’ cell histiocytosis. Pediatr Radiol 30:196–199CrossRefPubMed

16.

Fernandez-Latorre F, Menor-Serrano F, Alonso-Charterina S, et al (2000) Langerhans’ cell histiocytosis of the temporal bone in pediatric patients: imaging and follow-up. AJR Am J Roentgenol 174:217–221PubMed

17.

Abramson SJ, Berdon WE, Reilly BJ, et al (1987) Cavitation of anterior mediastinal masses in children with histiocytosis-X. Report of four cases with radiographic, pathologic findings and clinical follow-up. Pediatr Radiol 17:10–14PubMed

18.

Strottmann JM, Ginsberg LE, Stanton C (1995) Langerhans’ cell histiocytosis involving the corpus callosum and cerebellum: gadolinium-enhanced MRI. Neuroradiology 37:289–292CrossRefPubMed

19.

Kim E-Y, Choi J-U, Kim T-S, et al (1995) Huge Langerhans’ cell histiocytosis granuloma of choroid plexus in a child with Hand-Schüller-Christian disease. J Neurosurg 92:1080–1084

20.

Patel BJ, Chippindale AJ, Gupta SC (1991) Case report: small bowel histiocytosis-X. Clin Radiol 44:62–63PubMed

21.

Junewick JJ, Fitzgerald NE (1999) The thymus in Langerhans’ cell histiocytosis. Pediatr Radiol 29:904–907CrossRefPubMed

22.

Poe LB, Dubowy RL, Hochhauser L, et al (1994) Demyelinating and gliotic cerebellar lesions in Langerhans’ cell histiocytosis. AJNR Am J Neuroradiol 15:1919–1928

23.

Smets A, Mortele K, De Praeter G, et al (1997) Pulmonary and mediastinal lesions in children with Langerhans’ cell histiocytosis. Pediatr Radiol 27:873–876CrossRefPubMed

24.

Darvishian F, Hirawat S, Teichberg S, et al (2002) Langerhans’ cell histiocytosis in the parotid gland. Ann Clin Sci 32:201–206

25.

Meyer JS, Harty MP, Mahboubi S, et al (1995) Langerhans’ cell histiocytosis: presentation and evolution of radiologic findings with clinical correlation. Radiographics 15:1135–1146PubMed

26.

Kepes JJ, Kepes M (1969) Predominantly cerebral forms of histiocytosis X. A reappraisal of “Gagel’s hypothalamic granuloma”, “granuloma infiltrans of the hypothalamus” and “Ayala’s disease” with a report of four cases. Acta Neuropathol 14:77–98PubMed

27.

Maghnie M, Arico M, Vill A, et al (1992) MR of the hypothalamic-pituitary axis in Langerhans cell histiocytosis. Am J AJNR Neuroradiol 13:1365–1371

28.

Liang I, Korogi Y, Sugahar T, et al (2000) Dynamic MR imaging of neurohypophyseal germ cell tumors for differential diagnosis infundibular diseases. Acta Radiol 41:562–566CrossRefPubMed

29.

Favara BE, Jaffe T (1987) Pathology of Langerhans’ cell histiocytosis. Hematol Oncol Clin North Am 1:75–97PubMed

30.

Hamilton B, Connolly ES, Mitchell WT (1995) Isolated intramedullary histiocytosis X of the cervical spinal cord. J Neurosurg 83:716–718PubMed

31.

Lacroix M, Farmer JP, Meagher-Villemure K, et al (1996) Cauda equina histiocytosis X. Pediatr Neurol 14:231–235CrossRefPubMed

32.

Eung-Young K, Joong-Uhn C, Tai-Seung K, et al (1995) Huge Langerhans’ cell histiocytosis granuloma of choroid plexus in a child with Hand-Schüller-Christian disease. J Neurosurg 83:1080–1084PubMed

33.

Liebermann PH, Jones CR, Steinman RM, et al (1996) Langerhans’ cell (eosinophilic) granulomatosis: a clinicopathologic study encompassing 50 years: Am J Surg Pathol 20:519–552

34.

Sumner TE, Auringer ST, Preston AA (1993) Thymic calcifications in histiocytosis X. Pediatr Radiol 23:204–205PubMed

35.

Newton WA, Hamoudi AB, Shannon BR (1987) Role of the thymus in histiocytosis-X. Hematol Oncol Clin North Am 1:63–74PubMed

36.

Ha SY, Helms P, Fletcher M, et al (1992) Lung involvement in Langerhans’ cell histiocytosis: prevalence, clinical features and outcome. Pediatrics 89:466–469PubMed

37.

Bernstrand C, Cederlund K, Sandstedt B, et al (2001) Pulmonary abnormalities at long-term follow-up of patients with Langerhans’ cell histiocytosis. Med Pediatr Oncol 36:459–468CrossRefPubMed

38.

Soler P, Tazi A, Hance AJ (1995) Pulmonary Langerhans’ cell granulomatosis. Curr Opin Pulm Med 1:406–416PubMed

39.

Shaker KG, Umall CB, Fraire AE (1995) Langerhans’ cell histiocytosis of the lung in association with mediastinal lymphadenopathy. Pathol Int 45:762–766PubMed

40.

Kulwiec EL, Lynch Da, Aguayo SM, et al (1992) Imaging of pulmonary histiocytosis X. Radiographics 12:515–526PubMed

41.

Meyer JS, De Camargo B (1998) The role of radiology in the diagnosis and follow up of Langerhans’ cell histiocytosis. Hematol Oncol Clin North Am 12:307–326PubMed

42.

Brauner MW, Grenier P, Mouelhi MM, et al (1989) Pulmonary histiocytosis X: evaluation with high-resolution CT. Radiology 172:255–258PubMed

43.

Koh DM, Hansell DM (2000) Computed tomography of diffuse interstitial lung disease in children. Clin Radiol 55:659–667CrossRefPubMed

44.

Moore AD, Godwin JD, Müller NL, et al (1989) Pulmonary histiocytosis X: comparison of radiographic and CT findings. Radiology 172:249–254PubMed

45.

Braier J, Ciocca M, Latella A, et al (2002) Cholestasis, sclerosing cholangitis, and liver transplantation in Langerhans’ cell histiocytosis. Med Pediatr Oncol 38:178–182CrossRefPubMed

46.

Sisto A, Feldman P, Garel L, et al (1987) Primary sclerosing cholangitis: study of five cases and review of literature. Pediatrics 80:918–923PubMed

47.

Kaplan KJ, Goodman ZD, Ishak KG (1999) Liver involvement in Langerhans’ cell histiocytosis: a study of nine cases. Mod Pathol 12:370–378PubMed

48.

Geissmann F, Thoma C, Emile JF, et al (1996) Digestive tract involvement in Langerhans’ cell histiocytosis. J Pediatr 129:836–845PubMed

49.

Chan YL, Li CK, Lee CY (1997) Sonographic appearance of hepatic Langerhans’ cell histiocytosis. Clin Radiol 52:761–763PubMed

50.

Kim M, Lyu C, Jin Y, et al (1999) Langerhans’ cell histiocytosis as a cause of periportal abnormal signal intensity on MRI. Abdom Imaging 24:373–377CrossRefPubMed

51.

Arakawa A, Matsukawa T, Yamashita X, et al (1994) Periportal fibrosis in Langerhans’ cell histiocytosis mimicking multiple liver tumors: US, CT and MR findings. J Comput Assist Tomogr 18:157–159PubMed

52.

Nanduri VR, Kara K, Malone M, et al (1999) Colon involvement in Langerhans’ cell histiocytosis. J Pediatr Gastroenterol Nutr 29:462–466CrossRefPubMed

53.

Couderc L, Vannier JP, Marret S, et al (1997) Neonatal exudative enteropathy and Langerhans’ cell histiocytosis (in French). Arch Pediatr 4:1155PubMed

54.

Stuphen JL, Fechner RE (1986) Chronic gastroenteritis in a patient with histiocytosis X. J Pediatr Gastroeneterol Nutr 5:324–328

55.

Chu T, Jaffe R (1994) The normal Langerhans’ cell and the CLH cell. Br J Cancer 70:4–10

56.

Rosai J, Dorfman RF (1969) Sinus histiocytosis with massive lymphadenopathy. Arch Pathol 87:63–70

57.

McAlister WH, Herman T, Dehner LP (1990) Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Pediatr Radiol 20:425–432PubMed

58.

Levine EA, Landry MM (1994) Rosai-Dorfman disease of soft tissue. Surgery 155:650–652

59.

Kugler A, Middel P, Gross AJ, et al (1997) Unusual bilateral renal histiocytosis: extranodal variant of Rosai-Dorfman disease. Arch Pathol Lab Med 116:1366–1367

Titel: Extra-osseous involvement of Langerhans’ cell histiocytosis in children
verfasst von: Sabine Schmidt
Georg Eich
Sylviane Hanquinet
Heinz Tschäppeler
Peter Waibel
François Gudinchet
Publikationsdatum: 01.04.2004
Verlag: Springer-Verlag
Erschienen in: Pediatric Radiology / Ausgabe 4/2004
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-003-1118-z

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