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01.05.2007 | Original Article

Value of fetal cerebral MRI in sonographically proven cardiac rhabdomyoma

verfasst von: Matthias R. Mühler, Annett Rake, Michael Schwabe, Susanne Schmidt, Dietmar Kivelitz, Rabih Chaoui, Bernd Hamm

Erschienen in: Pediatric Radiology | Ausgabe 5/2007

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Abstract

Background

Tuberous sclerosis complex (TSC) is an autosomal dominant phakomatosis associated with intracardiac rhabdomyomas.

Objective

The aim of our study was to examine the value of cerebral MRI in diagnosing TSC in fetuses with intracardiac rhabdomyomas, applying the TSC Consensus Conference (TSCCC) criteria.

Materials and methods

In a prospective manner six consecutive fetuses with cardiac rhabdomyomas (21–34 weeks’ gestation) underwent cerebral MRI. The MRI results were correlated with clinical follow-up at 10–34 months after birth, histology, and genetic data.

Results

In five of the six fetuses the diagnosis of TSC was established. In two of five fetuses MRI demonstrated cerebral manifestations of TSC that correlated well with severe epilepsy manifesting during the follow-up period. In another two of five fetuses MRI as well as clinical follow-up were normal. One of five pregnancies was terminated and histology demonstrated microscopically small subependymal nodules not demonstrated by MRI.

Conclusion

The results of our study agree with the available literature that fetal MRI is sufficient for the detection of cerebral lesions in TSC and should be better promoted. The TSCCC criteria can also be applied to fetal MRI.

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Titel: Value of fetal cerebral MRI in sonographically proven cardiac rhabdomyoma
verfasst von: Matthias R. Mühler
Annett Rake
Michael Schwabe
Susanne Schmidt
Dietmar Kivelitz
Rabih Chaoui
Bernd Hamm
Publikationsdatum: 01.05.2007
Verlag: Springer-Verlag
Erschienen in: Pediatric Radiology / Ausgabe 5/2007
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-007-0436-y

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Value of fetal cerebral MRI in sonographically proven cardiac rhabdomyoma

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Background

Objective

Materials and methods

Results

Conclusion

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