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Erschienen in: Pediatric Radiology 10/2011

01.10.2011 | Original Article

Functional hepatobiliary MR imaging in children

verfasst von: Anobel Tamrazi, Shreyas S. Vasanawala

Erschienen in: Pediatric Radiology | Ausgabe 10/2011

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Abstract

Background

Clinical application efforts for the hepatocyte-specific MRI contrast agent gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) have mainly been directed toward detection and characterization of various hepatic masses in the adult population.

Objective

Here we report our initial experience with Gd-EOB-DTPA for evaluating congenital and acquired hepatobiliary pathologies in the pediatric population.

Materials and methods

Twenty-one consecutive children receiving Gd-EOB-DTPA for functional hepatobiliary evaluation at our institution were retrospectively identified with IRB approval. The use of Gd-EOB-DTPA was classified in each case as definite, potential, or no clinical utility, focusing on the clinical value gained beyond traditional noncontrast fluid-sensitive MR cholangiopancreatography (FS-MRCP) and other imaging modalities.

Results

Definite added value of Gd-EOB-DTPA was found in 12 patients, with potential value in 4 patients, and no value in 5 patients. Benefit was seen in cases of iatrogenic and non-iatrogenic biliary strictures, perihepatic fluid collections for biliary leak, hepatobiliary dysfunction in the absence of hyperbilirubinemia, and in the functional exclusion of cystic duct occlusion that can be seen in acute cholecystitis.

Conclusion

This is the first reported series of children with Gd-EOB-DTPA and this early work suggests potential pediatric applications.
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Metadaten
Titel
Functional hepatobiliary MR imaging in children
verfasst von
Anobel Tamrazi
Shreyas S. Vasanawala
Publikationsdatum
01.10.2011
Verlag
Springer-Verlag
Erschienen in
Pediatric Radiology / Ausgabe 10/2011
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-011-2086-3

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