Skip to main content
Erschienen in: Pediatric Radiology 10/2014

01.10.2014 | Original Article

Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children

verfasst von: Fernando M. Gómez, Premal A. Patel, Samuel Stuart, Derek J. Roebuck

Erschienen in: Pediatric Radiology | Ausgabe 10/2014

Einloggen, um Zugang zu erhalten

Abstract

Background

Ablation techniques are widely used for solid malignant tumors in adults. There is no large series assessing the effectiveness of local ablative therapies in the treatment of malignant or aggressive benign lesions in children.

Objective

To review the existing evidence on the techniques and results of ablation for pediatric solid malignant or aggressive benign tumors.

Materials and methods

We searched MEDLINE for papers published between 1995 and 2012 that reported outcomes of radiofrequency, microwave and cryoablation, interstitial laser therapy, irreversible electroporation and percutaneous ethanol injection for patients younger than 18 years old. Data collection included factors related to the patient, tumor biology, ablation technique and cancer-specific endpoints. Additional series of predominantly adults including data on patients younger than 18 years old were also identified.

Results

We identified 28 patients treated by ablation in 29 regions: 5 patients undergoing ablation for liver lesions, 9 patients for lung metastases, 11 patients for bone and/or soft tissue and 4 patients for kidney or pancreas. The ablation was performed to treat primary tumors, local recurrences and metastases. The histology of the tumors was osteosarcoma in 6 patients, Wilms tumor in 3, rhabdomyosarcoma in 3, hepatoblastoma in 3, desmoid tumor in 3, adrenocortical carcinoma in 2 and a single case each of leiomyosarcoma, Ewing sarcoma, paraganglioma, solid-pseudopapillary neoplasm, sacrococcygeal teratoma, hepatic adenoma, juxtaglomerular cell tumor and plantar fibromatosis. Eighteen of the patients (64%) experienced a complication, but only 6 (21%) of these needed treatment other than supportive care.

Conclusions

Although ablative techniques are feasible and promising treatments for certain pediatric tumors, large multicenter prospective trials will be needed to establish efficacy.
Literatur
1.
Zurück zum Zitat Vogl TJ, Naguib NN, Lehnert T et al (2011) Radiofrequency, microwave and laser ablation of pulmonary neoplasms: clinical studies and technical considerations–review article. Eur J Radiol 77:346–357PubMedCrossRef Vogl TJ, Naguib NN, Lehnert T et al (2011) Radiofrequency, microwave and laser ablation of pulmonary neoplasms: clinical studies and technical considerations–review article. Eur J Radiol 77:346–357PubMedCrossRef
2.
3.
Zurück zum Zitat Palussière J, Italiano A, Descat E et al (2011) Sarcoma lung metastases treated with percutaneous radiofrequency ablation: results from 29 patients. Ann Surg Oncol 18:3771–3777PubMedCrossRef Palussière J, Italiano A, Descat E et al (2011) Sarcoma lung metastases treated with percutaneous radiofrequency ablation: results from 29 patients. Ann Surg Oncol 18:3771–3777PubMedCrossRef
4.
Zurück zum Zitat Martin RC 2nd, McFarland K, Ellis S et al (2013) Irreversible electroporation in locally advanced pancreatic cancer: potential improved overall survival. Ann Surg Oncol 20:S443–S449PubMedCrossRef Martin RC 2nd, McFarland K, Ellis S et al (2013) Irreversible electroporation in locally advanced pancreatic cancer: potential improved overall survival. Ann Surg Oncol 20:S443–S449PubMedCrossRef
5.
Zurück zum Zitat Lencioni R, Crocetti L (2012) Local-regional treatment of hepatocellular carcinoma. Radiology 262:43–58PubMedCrossRef Lencioni R, Crocetti L (2012) Local-regional treatment of hepatocellular carcinoma. Radiology 262:43–58PubMedCrossRef
6.
Zurück zum Zitat Goldberg SN, Grassi CJ, Cardella JF et al (2009) Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 20:S377–S390PubMedCrossRef Goldberg SN, Grassi CJ, Cardella JF et al (2009) Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 20:S377–S390PubMedCrossRef
7.
Zurück zum Zitat European Association for Study of Liver; European Organisation for Research and Treatment of Cancer (2012) EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. Eur J Cancer 48:599–641, Erratum in: Eur J Cancer 48:1255–1256CrossRef European Association for Study of Liver; European Organisation for Research and Treatment of Cancer (2012) EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. Eur J Cancer 48:599–641, Erratum in: Eur J Cancer 48:1255–1256CrossRef
8.
Zurück zum Zitat Vogl TJ, Wissniowski TT, Naguib NN et al (2009) Activation of tumor-specific T lymphocytesafter laser-induced thermotherapy in patients with colorectal liver metastases. Cancer Immunol Immunother 58:1557–1563PubMedCrossRef Vogl TJ, Wissniowski TT, Naguib NN et al (2009) Activation of tumor-specific T lymphocytesafter laser-induced thermotherapy in patients with colorectal liver metastases. Cancer Immunol Immunother 58:1557–1563PubMedCrossRef
9.
Zurück zum Zitat Mizukoshi E, Yamashita T, Arai K et al (2013) Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma. Hepatology 57:1448–1457PubMedCrossRef Mizukoshi E, Yamashita T, Arai K et al (2013) Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma. Hepatology 57:1448–1457PubMedCrossRef
10.
Zurück zum Zitat Rao P, Escudier B, de Baere T (2011) Spontaneous regression of multiple pulmonary metastases after radiofrequency ablation of a single metastasis. Cardiovasc Intervent Radiol 34:424–430PubMedCrossRef Rao P, Escudier B, de Baere T (2011) Spontaneous regression of multiple pulmonary metastases after radiofrequency ablation of a single metastasis. Cardiovasc Intervent Radiol 34:424–430PubMedCrossRef
11.
Zurück zum Zitat Ahmed M, Moussa M, Goldberg SN (2012) Synergy in cancer treatment between liposomal chemotherapeutics and thermal ablation. Chem Phys Lipids 165:424–437PubMedCrossRefPubMedCentral Ahmed M, Moussa M, Goldberg SN (2012) Synergy in cancer treatment between liposomal chemotherapeutics and thermal ablation. Chem Phys Lipids 165:424–437PubMedCrossRefPubMedCentral
12.
Zurück zum Zitat Ikuta S, Kurimoto A, Iida H et al (2012) Optimal combination of radiofrequency ablation with chemoradiotherapy for locally advanced pancreatic cancer. World J Clin Oncol 3:12–14PubMedCrossRefPubMedCentral Ikuta S, Kurimoto A, Iida H et al (2012) Optimal combination of radiofrequency ablation with chemoradiotherapy for locally advanced pancreatic cancer. World J Clin Oncol 3:12–14PubMedCrossRefPubMedCentral
13.
Zurück zum Zitat van Laarhoven S, van Baren R, Tamminga RY et al (2012) Radiofrequency ablation in the treatment of liver tumors in children. J Pediatr Surg 47:e7–e12PubMedCrossRef van Laarhoven S, van Baren R, Tamminga RY et al (2012) Radiofrequency ablation in the treatment of liver tumors in children. J Pediatr Surg 47:e7–e12PubMedCrossRef
14.
Zurück zum Zitat Rimondi E, Mavrogenis AF, Rossi G et al (2012) Radiofrequency ablation for non-spinal osteoid osteomas in 557 patients. Eur Radiol 22:181–188PubMedCrossRef Rimondi E, Mavrogenis AF, Rossi G et al (2012) Radiofrequency ablation for non-spinal osteoid osteomas in 557 patients. Eur Radiol 22:181–188PubMedCrossRef
15.
Zurück zum Zitat Hill RH 3rd, Shiels WE 2nd, Foster JA et al (2012) Percutaneous drainage and ablation as first line therapy for macrocystic and microcystic orbital lymphatic malformations. Ophthal Plast Reconstr Surg 28:119–125PubMedCrossRef Hill RH 3rd, Shiels WE 2nd, Foster JA et al (2012) Percutaneous drainage and ablation as first line therapy for macrocystic and microcystic orbital lymphatic malformations. Ophthal Plast Reconstr Surg 28:119–125PubMedCrossRef
16.
Zurück zum Zitat Kim YJ, Baek JH, Ha EJ et al (2012) Cystic versus predominantly cystic thyroid nodules: efficacy of ethanol ablation and analysis of related factors. Eur Radiol 22:1573–1578PubMedCrossRef Kim YJ, Baek JH, Ha EJ et al (2012) Cystic versus predominantly cystic thyroid nodules: efficacy of ethanol ablation and analysis of related factors. Eur Radiol 22:1573–1578PubMedCrossRef
17.
Zurück zum Zitat Hoffer FA, Daw NC, Xiong X et al (2009) A phase 1/pilot study of radiofrequency ablation for the treatment of recurrent pediatric solid tumors. Cancer 115:1328–1337PubMedCrossRefPubMedCentral Hoffer FA, Daw NC, Xiong X et al (2009) A phase 1/pilot study of radiofrequency ablation for the treatment of recurrent pediatric solid tumors. Cancer 115:1328–1337PubMedCrossRefPubMedCentral
18.
Zurück zum Zitat Pappas L, Seefelder C (2009) Anesthetic consideration for radiofrequency ablation of a suspected paraganglioma metastasis in a child. Paediatr Anaesth 19:913–914PubMedCrossRef Pappas L, Seefelder C (2009) Anesthetic consideration for radiofrequency ablation of a suspected paraganglioma metastasis in a child. Paediatr Anaesth 19:913–914PubMedCrossRef
19.
Zurück zum Zitat Lessard AM, Gilchrist J, Schaefer L et al (2009) Palliation of recurrent Ewing sarcoma of the pelvis with cryoablation and somatosensory-evoked potentials. J Pediatr Hematol Oncol 31:18–21PubMedCrossRef Lessard AM, Gilchrist J, Schaefer L et al (2009) Palliation of recurrent Ewing sarcoma of the pelvis with cryoablation and somatosensory-evoked potentials. J Pediatr Hematol Oncol 31:18–21PubMedCrossRef
20.
Zurück zum Zitat Cowles RA, Stolar CJ, Kandel JJ et al (2006) Preoperative angiography with embolization and radiofrequency ablation as novel adjuncts to safe surgical resection of a large, vascular sacrococcygeal teratoma. Pediatr Surg Int 22:554–556PubMedCrossRef Cowles RA, Stolar CJ, Kandel JJ et al (2006) Preoperative angiography with embolization and radiofrequency ablation as novel adjuncts to safe surgical resection of a large, vascular sacrococcygeal teratoma. Pediatr Surg Int 22:554–556PubMedCrossRef
21.
Zurück zum Zitat Ilaslan H, Schils J, Joyce M et al (2010) Radiofrequency ablation: another treatment option for local control of desmoid tumors. Skelet Radiol 39:169–173CrossRef Ilaslan H, Schils J, Joyce M et al (2010) Radiofrequency ablation: another treatment option for local control of desmoid tumors. Skelet Radiol 39:169–173CrossRef
22.
Zurück zum Zitat Nashida Y, Yamakado K, Kumamoto T et al (2007) Radiofrequency ablation used for the treatment of frequently recurrent rhabdomyosarcoma in the masticator space in a 10-year-old girl. J Pediatr Hematol Oncol 29:640–642PubMedCrossRef Nashida Y, Yamakado K, Kumamoto T et al (2007) Radiofrequency ablation used for the treatment of frequently recurrent rhabdomyosarcoma in the masticator space in a 10-year-old girl. J Pediatr Hematol Oncol 29:640–642PubMedCrossRef
23.
Zurück zum Zitat Burgoyne LL, Pereiras LA, Laningham F et al (2008) Near-fatal acute bronchovenous fistula in a child undergoing radiofrequency ablation of a metastatic lung tumor. Paediatr Anaesth 18:1131–1133PubMedCrossRef Burgoyne LL, Pereiras LA, Laningham F et al (2008) Near-fatal acute bronchovenous fistula in a child undergoing radiofrequency ablation of a metastatic lung tumor. Paediatr Anaesth 18:1131–1133PubMedCrossRef
24.
Zurück zum Zitat Hara F, Kishikawa T, Tomishige H et al (2003) A child with adrenocortical carcinoma who underwent percutaneous ethanol injection therapy for liver metastasis. J Pediatr Surg 38:1237–1240PubMedCrossRef Hara F, Kishikawa T, Tomishige H et al (2003) A child with adrenocortical carcinoma who underwent percutaneous ethanol injection therapy for liver metastasis. J Pediatr Surg 38:1237–1240PubMedCrossRef
25.
Zurück zum Zitat Rocourt DV, Shiels WE, Hammond S et al (2006) Contemporary management of benign hepatic adenoma using percutaneous radiofrequency ablation. J Pediatr Surg 41:1149–1152PubMedCrossRef Rocourt DV, Shiels WE, Hammond S et al (2006) Contemporary management of benign hepatic adenoma using percutaneous radiofrequency ablation. J Pediatr Surg 41:1149–1152PubMedCrossRef
26.
Zurück zum Zitat Ye J, Shu Q, Li M et al (2008) Percutaneous radiofrequency ablation for treatment of hepatoblastoma recurrence. Pediatr Radiol 38:1021–1023PubMedCrossRef Ye J, Shu Q, Li M et al (2008) Percutaneous radiofrequency ablation for treatment of hepatoblastoma recurrence. Pediatr Radiol 38:1021–1023PubMedCrossRef
27.
Zurück zum Zitat Brown SD, Vansonnenberg E, Morrison PR et al (2005) CT-radiofrequency ablation of pediatric Wilms tumor in a solitary kidney. Pediatr Radiol 35:923–928PubMedCrossRef Brown SD, Vansonnenberg E, Morrison PR et al (2005) CT-radiofrequency ablation of pediatric Wilms tumor in a solitary kidney. Pediatr Radiol 35:923–928PubMedCrossRef
28.
Zurück zum Zitat Gandhi S, Meech SJ, Puthawala MA et al (2005) Combined computed tomography-guided radiofrequency ablation and brachytherapy in a child with multiple recurrences of Wilms’ tumor. J Pediatr Hematol Oncol 27:377–379PubMedCrossRef Gandhi S, Meech SJ, Puthawala MA et al (2005) Combined computed tomography-guided radiofrequency ablation and brachytherapy in a child with multiple recurrences of Wilms’ tumor. J Pediatr Hematol Oncol 27:377–379PubMedCrossRef
29.
Zurück zum Zitat Sugito K, Kusafuka T, Hoshino M et al (2010) Application of radiofrequency ablation for giant solid pseudopapillary tumor of the pancreas. Pediatr Int 52:e29–e31PubMedCrossRef Sugito K, Kusafuka T, Hoshino M et al (2010) Application of radiofrequency ablation for giant solid pseudopapillary tumor of the pancreas. Pediatr Int 52:e29–e31PubMedCrossRef
30.
Zurück zum Zitat Kirkham AP, Ho SG, Paterson RF et al (2008) Treatment of a juxtaglomerular tumor with radiofrequency ablation. Urology 71:168.e1-4PubMedCrossRef Kirkham AP, Ho SG, Paterson RF et al (2008) Treatment of a juxtaglomerular tumor with radiofrequency ablation. Urology 71:168.e1-4PubMedCrossRef
Metadaten
Titel
Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children
verfasst von
Fernando M. Gómez
Premal A. Patel
Samuel Stuart
Derek J. Roebuck
Publikationsdatum
01.10.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Radiology / Ausgabe 10/2014
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-014-3001-5

Weitere Artikel der Ausgabe 10/2014

Pediatric Radiology 10/2014 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.