nach oben

Pediatric Radiology

Erschienen in:

01.05.2016 | Pediatric Body MRI

Whole-body magnetic resonance imaging in children: technique and clinical applications

verfasst von: Eric P. Eutsler, Geetika Khanna

Erschienen in: Pediatric Radiology | Ausgabe 6/2016

Einloggen, um Zugang zu erhalten

Abstract

Whole-body MR imaging is being increasingly used in children to evaluate the extent of various oncologic and non-oncologic entities. The lack of exposure to ionizing radiation, excellent soft-tissue contrast (even without the use of contrast agents), and functional imaging capabilities make it especially suitable for screening and surveillance in the pediatric population. Technical developments such as moving table platforms, multi-channel/multi-element surface coils, and parallel imaging allow imaging of the entire body with multiple sequences in a reasonable 30- to 40-min time frame, which has facilitated its acceptance in routine clinical practice. The initial investigations in whole-body MR imaging were primarily focused on oncologic applications such as tumor screening and staging. The exquisite sensitivity of fluid-sensitive MR sequences to many different types of pathology has led to new applications of whole-body MR imaging in evaluation of multifocal rheumatologic conditions. Availability of blood pool contrast agents has allowed whole-body MR angiographic imaging of vascular malformations, vasculitides and vasculopathies. Whole-body MRI is being applied for delineating the extent and distribution of systemic and multifocal diseases, establishing diagnoses, assessing treatment response, and surveillance imaging. This article reviews the technique and clinical applications of whole-body MR imaging in children.

Eustace S, Tello R, DeCarvalho V et al (1998) Whole body turbo STIR MRI in unknown primary tumor detection. J Magn Reson Imaging 8:751–753CrossRefPubMed

Chavhan GB, Babyn PS (2011) Whole-body MR imaging in children: principles, technique, current applications, and future directions. Radiographics 31:1757–1772CrossRefPubMed

Goo HW (2015) Whole-body MRI in children: current imaging techniques and clinical applications. Korean J Radiol 16:973–985CrossRefPubMedPubMedCentral

Lauenstein TC, Freudenberg LS, Goehde SC et al (2002) Whole-body MRI using a rolling table platform for the detection of bone metastases. Eur Radiol 12:2091–2099CrossRefPubMed

Koh DM, Blackledge M, Padhani AR et al (2012) Whole-body diffusion-weighted MRI: tips, tricks, and pitfalls. AJR Am J Roentgenol 199:252–262CrossRefPubMed

Kwee TC, Vermoolen MA, Akkerman EA et al (2014) Whole-body MRI, including diffusion-weighted imaging, for staging lymphoma: comparison with CT in a prospective multicenter study. J Magn Reson Imaging 40:26–36CrossRefPubMed

Hirsch W, Kluge R et al (2005) Preliminary results in whole body MRI in children — a prospective study [abstract]. Pediatr Radiol 35:S89CrossRef

Farmakis SG, Khanna G (2014) Extracardiac applications of MR blood pool contrast agent in children. Pediatr Radiol 44:1598–1609, quiz 1595–1597 CrossRefPubMed

Nayak AB, Luhar A, Hanudel M et al (2015) High-resolution, whole-body vascular imaging with ferumoxytol as an alternative to gadolinium agents in a pediatric chronic kidney disease cohort. Pediatr Nephrol 30:515–521CrossRefPubMed

10.

Friedman DN, Lis E, Sklar CA et al (2014) Whole-body magnetic resonance imaging (WB-MRI) as surveillance for subsequent malignancies in survivors of hereditary retinoblastoma: a pilot study. Pediatr Blood Cancer 61:1440–1444CrossRefPubMedPubMedCentral

11.

Jasperson KW, Kohlmann W, Gammon A et al (2014) Role of rapid sequence whole-body MRI screening in SDH-associated hereditary paraganglioma families. Fam Cancer 13:257–265CrossRefPubMed

12.

Villani A, Tabori U, Schiffman J et al (2011) Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study. Lancet Oncol 12:559–567CrossRefPubMed

13.

Gonzalez KD, Noltner KA, Buzin CH et al (2009) Beyond Li Fraumeni syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol 27:1250–1256CrossRefPubMed

14.

Anupindi SA, Bedoya MA, Lindell RB et al (2015) Diagnostic performance of whole-body MRI as a tool for cancer screening in children with genetic cancer-predisposing conditions. AJR Am J Roentgenol 205:400–408CrossRefPubMed

15.

Hirbe AC, Gutmann DH (2014) Neurofibromatosis type 1: a multidisciplinary approach to care. Lancet Neurol 13:834–843CrossRefPubMed

16.

Evans DG, Baser ME, McGaughran J et al (2002) Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet 39:311–314CrossRefPubMedPubMedCentral

17.

Mautner VF, Asuagbor FA, Dombi E et al (2008) Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1. Neuro Oncol 10:593–598CrossRefPubMedPubMedCentral

18.

Nguyen R, Jett K, Harris GJ et al (2014) Benign whole body tumor volume is a risk factor for malignant peripheral nerve sheath tumors in neurofibromatosis type 1. J Neurooncol 116:307–313CrossRefPubMed

19.

Warbey VS, Ferner RE, Dunn JT et al (2009) [18F]FDG PET/CT in the diagnosis of malignant peripheral nerve sheath tumours in neurofibromatosis type-1. Eur J Nucl Med Mol Imaging 36:751–757CrossRefPubMed

20.

Derlin T, Tornquist K, Munster S et al (2013) Comparative effectiveness of 18F-FDG PET/CT versus whole-body MRI for detection of malignant peripheral nerve sheath tumors in neurofibromatosis type 1. Clin Nucl Med 38:e19–e25CrossRefPubMed

21.

Daldrup-Link HE, Franzius C, Link TM et al (2001) Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. AJR Am J Roentgenol 177:229–236CrossRefPubMed

22.

Mazumdar A, Siegel MJ, Narra V et al (2002) Whole-body fast inversion recovery MR imaging of small cell neoplasms in pediatric patients: a pilot study. AJR Am J Roentgenol 179:1261–1266CrossRefPubMed

23.

Punwani S, Taylor SA, Bainbridge A et al (2010) Pediatric and adolescent lymphoma: comparison of whole-body STIR half-Fourier RARE MR imaging with an enhanced PET/CT reference for initial staging. Radiology 255:182–190CrossRefPubMed

24.

Siegel MJ, Acharyya S, Hoffer FA et al (2013) Whole-body MR imaging for staging of malignant tumors in pediatric patients: results of the American College of Radiology Imaging Network 6660 Trial. Radiology 266:599–609CrossRefPubMedPubMedCentral

25.

Kwee TC, Takahara T, Luijten PR et al (2010) ADC measurements of lymph nodes: inter- and intra-observer reproducibility study and an overview of the literature. Eur J Radiol 75:215–220CrossRefPubMed

26.

Luna A, Sanchez-Gonzalez J, Caro P (2011) Diffusion-weighted imaging of the chest. Magn Reson Imaging Clin N Am 19:69–94CrossRefPubMed

27.

Littooij AS, Kwee TC, Barber I et al (2014) Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard. Eur Radiol 24:1153–1165CrossRefPubMed

28.

Klenk C, Gawande R, Uslu L et al (2014) Ionising radiation-free whole-body MRI versus (18)F-fluorodeoxyglucose PET/CT scans for children and young adults with cancer: a prospective, non-randomised, single-centre study. Lancet Oncol 15:275–285CrossRefPubMed

29.

Dillman JR, Ellis JH, Cohan RH et al (2007) Frequency and severity of acute allergic-like reactions to gadolinium-containing i.v. contrast media in children and adults. AJR Am J Roentgenol 189:1533–1538CrossRefPubMed

30.

Hirsch FW, Sattler B, Sorge I et al (2013) PET/MR in children. Initial clinical experience in paediatric oncology using an integrated PET/MR scanner. Pediatr Radiol 43:860–875CrossRefPubMedPubMedCentral

31.

Ponisio R, McConathy J, LaForest R et al (2015) Whole body simultaneous FDG-PET/MR for pediatric lymphoma: initial experience. Radiologic Society of North America, Chicago

32.

Schafer JF, Gatidis S, Schmidt H et al (2014) Simultaneous whole-body PET/MR imaging in comparison to PET/CT in pediatric oncology: initial results. Radiology 273:220–231CrossRefPubMed

33.

De Langen AJ, Vincent A, Velasquez LM et al (2012) Repeatability of 18F-FDG uptake measurements in tumors: a metaanalysis. J Nucl Med 53:701–708CrossRefPubMed

34.

Burris NS, Johnson KM, Larson PE et al (2016) Detection of small pulmonary nodules with ultrashort echo time sequences in oncology patients by using a PET/MR system. Radiology 278:239–246CrossRefPubMed

35.

Hong TS, Greer ML, Grosse-Wortmann L et al (2011) Whole-body MR angiography: initial experience in imaging pediatric vasculopathy. Pediatr Radiol 41:769–778CrossRefPubMed

36.

MacCarrick G, Black JH 3rd, Bowdin S et al (2014) Loeys-Dietz syndrome: a primer for diagnosis and management. Genet Med 16:576–587CrossRefPubMedPubMedCentral

37.

Khanna G, Sargar K, Baszis KW (2015) Pediatric vasculitis: recognizing multisystemic manifestations at body imaging. Radiographics 35:849–865CrossRefPubMed

38.

Giedion A, Holthusen W, Masel LF et al (1972) Subacute and chronic ‘symmetrical’ osteomyelitis. Ann Radiol 15:329–342PubMed

39.

Fritz J, Tzaribatchev N, Claussen CD et al (2009) Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. Radiology 252:842–851CrossRefPubMed

40.

Khanna G, Sato TS, Ferguson P (2009) Imaging of chronic recurrent multifocal osteomyelitis. Radiographics 29:1159–1177CrossRefPubMed

41.

Mandell GA, Contreras SJ, Conard K et al (1998) Bone scintigraphy in the detection of chronic recurrent multifocal osteomyelitis. J Nucl Med 39:1778–1783PubMed

42.

Guha A, Brown M, Jacobs B (2015) G357 chronic recurrent multifocal osteomyelitis (CRMO): the value of whole body MRI demonstrated by a series of 13 adult and 34 paediatric patients. Arch Dis Child 100:A146CrossRef

43.

Villani M, de Horatio L, Garganese M et al (2015) Whole-body MRI versus bone scintigraphy: which is the best diagnostic tool in patients with chronic recurrent multifocal osteomyelitis (CRMO)? Pediatr Rheumatol Online J 13:P58CrossRefPubMedCentral

44.

Catalano-Pons C, Comte A, Wipff J et al (2008) Clinical outcome in children with chronic recurrent multifocal osteomyelitis. Rheumatology 47:1397–1399CrossRefPubMed

45.

Voit AM, Arnoldi AP, Douis H et al (2015) Whole-body magnetic resonance imaging in chronic recurrent multifocal osteomyelitis: clinical longterm assessment may underestimate activity. J Rheumatol 42:1455–1462CrossRefPubMed

46.

Weckbach S, Schewe S, Michaely HJ et al (2011) Whole-body MR imaging in psoriatic arthritis: additional value for therapeutic decision making. Eur J Radiol 77:149–155CrossRefPubMed

47.

Carmona R, Harish S, Linda DD et al (2013) MR imaging of the spine and sacroiliac joints for spondyloarthritis: influence on clinical diagnostic confidence and patient management. Radiology 269:208–215CrossRefPubMed

48.

Aquino MR, Tse SM, Gupta S et al (2015) Whole-body MRI of juvenile spondyloarthritis: protocols and pictorial review of characteristic patterns. Pediatr Radiol 45:754–762CrossRefPubMed

49.

Rachlis AC, Babyn PS, Lobo-Meuller EB et al (2011) Whole body magnetic resonance imaging in juvenile spondyloarthritis: will it provide vital information compared to clinical exam alone? Arthritis Rheum 63:749CrossRef

50.

Badalian-Very G, Vergilio JA, Fleming M et al (2013) Pathogenesis of Langerhans cell histiocytosis. Annu Rev Pathol 8:1–20CrossRefPubMed

51.

Goo HW, Yang DH, Ra YS et al (2006) Whole-body MRI of Langerhans cell histiocytosis: comparison with radiography and bone scintigraphy. Pediatr Radiol 36:1019–1031CrossRefPubMed

52.

Phillips M, Allen C, Gerson P et al (2009) Comparison of FDG-PET scans to conventional radiography and bone scans in management of Langerhans cell histiocytosis. Pediatr Blood Cancer 52:97–101CrossRefPubMed

53.

Amini B, Kumar R, Wang WL (2013) Soft tissue Langerhans cell histiocytosis with secondary bone involvement in extremities: evolution of lesions in two patients. Skeletal Radiol 42:1301–1309CrossRefPubMed

54.

Perez-Rossello JM, Connolly SA, Newton AW et al (2010) Whole-body MRI in suspected infant abuse. AJR Am J Roentgenol 195:744–750CrossRefPubMed

55.

Malattia C, Damasio MB, Madeo A et al (2014) Whole-body MRI in the assessment of disease activity in juvenile dermatomyositis. Ann Rheum Dis 73:1083–1090CrossRefPubMed

56.

Hull MJ, Nazarian RM, Wheeler AE et al (2007) Resident physician opinions on autopsy importance and procurement. Hum Pathol 38:342–350CrossRefPubMed

57.

Burton EC, Phillips RS, Covinsky KE et al (2004) The relation of autopsy rate to physicians’ beliefs and recommendations regarding autopsy. Am J Med 117:255–261CrossRefPubMed

58.

Ben-Sasi K, Chitty LS, Franck LS et al (2013) Acceptability of a minimally invasive perinatal/paediatric autopsy: healthcare professionals’ views and implications for practice. Prenat Diagn 33:307–312PubMed

59.

Dirnhofer R, Jackowski C, Vock P et al (2006) VIRTOPSY: minimally invasive, imaging-guided virtual autopsy. Radiographics 26:1305–1333CrossRefPubMed

60.

Thayyil S (2011) Less invasive autopsy: an evidenced based approach. Arch Dis Child 96:681–687CrossRefPubMed

61.

Leadbetter K, Khanna G, Shimony J et al (2014) Is there a role for post-mortem MRI in the NICU? A prospective, single center study. Presented at the Pediatric Academic Societies meeting, Vancouver

62.

Breeze AC, Statham H, Hackett GA et al (2012) Perinatal postmortems: what is important to parents and how do they decide? Birth 39:57–64CrossRefPubMed

63.

Cohen MC, Paley MN, Griffiths PD et al (2008) Less invasive autopsy: benefits and limitations of the use of magnetic resonance imaging in the perinatal postmortem. Pediatr Dev Pathol 11:1–9CrossRefPubMed

64.

Cannie M, Votino C, Moerman P et al (2012) Acceptance, reliability and confidence of diagnosis of fetal and neonatal virtuopsy compared with conventional autopsy: a prospective study. Ultrasound Obstet Gynecol 39:659–665CrossRefPubMed

65.

Woodward PJ, Sohaey R, Harris DP et al (1997) Postmortem fetal MR imaging: comparison with findings at autopsy. AJR Am J Roentgenol 168:41–46CrossRefPubMed

66.

Ruegger CM, Bartsch C, Martinez RM et al (2014) Minimally invasive, imaging guided virtual autopsy compared to conventional autopsy in foetal, newborn and infant cases: study protocol for the paediatric virtual autopsy trial. BMC Pediatr 14:15CrossRefPubMedPubMedCentral

67.

Sebire NJ, Weber MA, Thayyil S et al (2012) Minimally invasive perinatal autopsies using magnetic resonance imaging and endoscopic postmortem examination (‘keyhole autopsy’): feasibility and initial experience. J Matern Fetal Neonatal Med 25:513–518CrossRefPubMed

68.

Brookes JA, Hall-Craggs MA, Sams VR et al (1996) Non-invasive perinatal necropsy by magnetic resonance imaging. Lancet 348:1139–1141CrossRefPubMed

69.

Thayyil S, Sebire NJ, Chitty LS et al (2013) Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study. Lancet 382:223–233CrossRefPubMed

70.

Griffiths PD, Variend D, Evans M et al (2003) Postmortem MR imaging of the fetal and stillborn central nervous system. AJNR Am J Neuroradiol 24:22–27PubMed

71.

Van der Made AD, Maas M, Beenen LF et al (2013) Postmortem imaging exposed: an aid in MR imaging of musculoskeletal structures. Skeletal Radiol 42:467–472CrossRefPubMed

72.

Thayyil S, Sebire NJ, Chitty LS et al (2011) Post mortem magnetic resonance imaging in the fetus, infant and child: a comparative study with conventional autopsy (MaRIAS Protocol). BMC Pediatr 11:120CrossRefPubMedPubMedCentral

Titel: Whole-body magnetic resonance imaging in children: technique and clinical applications
verfasst von: Eric P. Eutsler
Geetika Khanna
Publikationsdatum: 01.05.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Radiology / Ausgabe 6/2016
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-016-3586-y

Neu im Fachgebiet Radiologie

18.04.2024 | Pädiatrische Notfallmedizin | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Whole-body magnetic resonance imaging in children: technique and clinical applications

Abstract

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Quantitative Angiografie könnte IVUS-Alternative darstellen

Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2016

Body MR angiography in children: how we do it

Current role of body MRI in pediatric oncology

How we do it: MR enterography

Diffusion-weighted imaging in pediatric body magnetic resonance imaging

Magnetic resonance imaging of Müllerian duct anomalies in children

Magnetic resonance imaging of pancreaticobiliary diseases in children: from technique to practice

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Quantitative Angiografie könnte IVUS-Alternative darstellen

Update Radiologie