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Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1α

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Abstract.

A strong correlation between the TT–889 genotype over CC–889 of the interleukin-1α (IL-1α) transcription regulatory region and age of Alzheimer's disease onset has recently been reported. To determine the functional effects of the genetic variants on plasma protein levels, we cloned the promoter region and determined its activity. The TT genotype significantly increased the transcriptional activity of the IL-1 α gene with respect to the CC genotype. A slight increase of the IL-1α mRNA and protein levels was also observed in the plasma.

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Authors and Affiliations

  1. Institute of Biomedical Sciences and Department of Neurology, Ospedale Luigi Sacco, Milan, Italy, , , , ,

    Roberto Dominici, Davide Archi & Claudio Mariani

  2. Institute for Biomedical Technology – CNR Via F. lli Cervi 93, 20090 Segrate, Milan, Italy, , , , ,

    Monica Cattaneo & Ida Biunno

  3. Neuroimmunology Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy, , , , ,

    Luigi Grimaldi

  4. Department of Biomedical Science and Centro Interdisciplinare Studi Bio-molecolari e Applicazioni Industriali, University of Milan, Via F.lli Cervi 93, 20090 Segrate, Milan, Italy, , , , ,

    Giulia Malferrari

Authors
  1. Roberto Dominici
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  2. Monica Cattaneo
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  3. Giulia Malferrari
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  4. Davide Archi
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  5. Claudio Mariani
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  6. Luigi Grimaldi
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  7. Ida Biunno
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Dominici, R., Cattaneo, M., Malferrari, G. et al. Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1α. Immunogenetics 54, 82–86 (2002). https://doi.org/10.1007/s00251-002-0445-9

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  • DOI: https://doi.org/10.1007/s00251-002-0445-9

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