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The −159C/T polymorphism in the CD14 gene and the risk of asthma: a meta-analysis

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Abstract

The −159C/T polymorphism in the CD14 gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study is to investigate the association between the −159C/T polymorphism in the CD14 gene and the risk of asthma by meta-analysis. We searched Pubmed, Embase, CNKI database, Wanfang database, Weipu database, and Chinese Biomedical database, covering all publications (last search been performed on April 20, 2010). Statistical analysis was performed by using the softwares Revman 4.2 and STATA 10.0. A total of 17 case–control studies in 17 articles (4,246 cases and 3,631 controls) were included in this meta-analysis. There was no association between this polymorphism and asthma risk in combined analyses (odds ratio (OR) = 0.86 and 95% confidence interval (95% CI) = 0.72–1.02, P = 0.09 for TC + TT vs. CC). In the subgroup analysis by age, ethnicity, and atopic status, no significant associations of asthma risks were obtained from age groups, ethnic groups, and atopic groups for TC + TT vs. CC comparison. For atopic population, significant decreased atopic asthma risks were found among Asian population (OR = 0.69, 95% CI 0.52–0.92, P = 0.01) and children population (OR = 0.69, 95% CI 0.54–0.89, P = 0.0004) for TC + TT vs. CC comparison. This meta-analysis suggests that CD14 is a candidate gene for atopic asthma susceptibility. The −159C/T polymorphism may be a protective factor for atopic asthma in Asian and children. More studies are needed to validate these associations.

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Abbreviations

HWE:

Hardy–Weinberg equilibrium

OR:

Odds ratio

CI:

Confidence interval

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Acknowledgments

The authors thank Prof. Lidwien A. M. Smit for providing original data of their study.

Funding

This study was supported by grants #30470761 and 30871117 from National Natural Science Foundation of China.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Respiratory Medicine, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan, 610041, China

    Yonggang Zhang, Can Tian, Quocuo Meilang, Chunhong Peng & Hong Fan

  2. Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, 325035, China

    Jie Zhang

  3. Department of Respiratory Medicine, The 452nd Military Hospital of China, Chengdu, Sichuan, 610041, China

    Xiaobo Li

  4. Department of Health Statistics, West China of Public Health, Sichuan University, Chengdu, Sichuan, 610041, China

    Hua Wan

  5. Department of Laboratory Medicine, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan, 610041, China

    Chao He, Liang Guo, Lina Duo & Hong Fan

  6. West China Hospital/West China Medical School, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan, 610041, China

    Jin Huang

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  1. Yonggang Zhang
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  2. Can Tian
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  11. Jin Huang
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  12. Hong Fan
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Corresponding authors

Correspondence to Jin Huang or Hong Fan.

Additional information

Yonggang Zhang and Can Tian contributed equally to this work.

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Supplement Fig. 1

Meta-analysis with a random-effects model for the association between asthma risk and the CD14 −159C/T polymorphism (TT + TC vs. CC): subgroup analysis by ethnicity (DOC 41 kb)

Supplement Fig. 2

Meta-analysis with a random-effects model for the association between asthma risk and the CD14 −159C/T polymorphism (TT + TC vs. CC): subgroup analysis by age (DOC 39 kb)

Supplement Fig. 3

Meta-analysis with a random-effects model for the association between asthma risk and the CD14 −159C/T polymorphism (TT + TC vs. CC): subgroup analysis by atopic status. (DOC 43 kb)

Supplement Fig. 4

Meta-analysis with a random-effects model for the association between atopic asthma risk and the CD14 −159C/T polymorphism (TT + TC vs. CC): subgroup analysis by age (DOC 35 kb)

Supplement Fig. 5

Meta-analysis with a random-effects model for the association between atopic asthma risk and the CD14 −159C/T polymorphism (TT + TC vs. CC): subgroup analysis by ethnicity (DOC 37 kb)

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Zhang, Y., Tian, C., Zhang, J. et al. The −159C/T polymorphism in the CD14 gene and the risk of asthma: a meta-analysis. Immunogenetics 63, 23–32 (2011). https://doi.org/10.1007/s00251-010-0489-1

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