nach oben

Skeletal Radiology

Erschienen in:

01.05.2009 | Review Article

Bone marrow edema syndrome

verfasst von: Anastasios V. Korompilias, Apostolos H. Karantanas, Marios G. Lykissas, Alexandros E. Beris

Erschienen in: Skeletal Radiology | Ausgabe 5/2009

Einloggen, um Zugang zu erhalten

Abstract

Bone marrow edema syndrome (BMES) refers to transient clinical conditions with unknown pathogenic mechanism, such as transient osteoporosis of the hip (TOH), regional migratory osteoporosis (RMO), and reflex sympathetic dystrophy (RSD). BMES is primarily characterized by bone marrow edema (BME) pattern. The disease mainly affects the hip, the knee, and the ankle of middle-aged males. Many hypotheses have been proposed to explain the pathogenesis of the disease. Unfortunately, the etiology of BMES remains obscure. The hallmark that separates BMES from other conditions presented with BME pattern is its self-limited nature. Laboratory tests usually do not contribute to the diagnosis. Histological examination of the lesion is unnecessary. Plain radiographs may reveal regional osseous demineralization. Magnetic resonance imaging is mainly used for the early diagnosis and monitoring the progression of the disease. Early differentiation from other aggressive conditions with long-term sequelae is essential in order to avoid unnecessary treatment. Clinical entities, such as TOH, RMO, and RSD are spontaneously resolving, and surgical treatment is not needed. On the other hand, early differential diagnosis and surgical treatment in case of osteonecrosis is of crucial importance.

Curtiss PH Jr, Kincaid WE. Transitory demineralization of the hip in pregnancy. A report of three cases. J Bone Joint Surg Am 1959; 41: 1327–1333.PubMed

Hofmann S, Kramer J, Vakil-Adli A, Aigner N, Breitenseher M. Painful bone marrow edema of the knee: differential diagnosis and therapeutic concepts. Orthop Clin N Am 2004; 35: 321–333.CrossRef

Lakhanpal S, Ginsburg WW, Luthra HS, Hunder GG. Transient regional osteoporosis. A study of 56 cases and review of the literature. Ann Intern Med 1987; 106: 444–450.PubMed

Hofmann S, Engel A, Neuhold A, Leder K, Kramer J, Plenk H Jr. Bone-marrow oedema syndrome and transient osteoporosis of the hip. An MRI-controlled study of treatment by core decompression. J Bone Jt Surg Br 1993; 75: 210–216.

Koo KH, Dussault R, Kaplan PA, et al. Age-related marrow conversion in the proximal metaphysis of the femur: evaluation with T1-weighted MR imaging. Radiology 1998; 206: 745–748.PubMed

Trevisan C, Ortolani S. Bone loss and recovery in regional migratory osteoporosis. Osteoporos Int 2002; 13: 901–906.PubMedCrossRef

Rosen RA. Transitory demineralization of the femoral head. Radiology 1970; 94: 509–512.PubMed

Zanetti M, Bruder E, Romero J, Hodler J. Bone marrow edema pattern in osteoarthritic knees: correlation between MR imaging and histologic findings. Radiology 2000; 215: 835–840.PubMed

Hofmann S, Kramer J, Breitenseher M, Pietsch M, Aigner N. The painful bone marrow edema in the knee: differential diagnosis and therapeutic possibilities. Orthopade 2006; 35: 463–477.PubMedCrossRef

10.

Beltran J, Shankman S. Magnetic resonance imaging of bone marrow disorders of the knee. Magn Reson Imaging Clin N Am 1994; 2: 463–473.PubMed

11.

Noorda RJ, van der Aa JP, Wuisman PI, David EF, Lips PT, van der Valk P. Transient osteoporosis and osteogenesis imperfecta. A case report. Clin Orthop Relat Res 1997; 337: 249–255.PubMedCrossRef

12.

Funk JL, Shoback DM, Genant HK. Transient osteoporosis of the hip in pregnancy: natural history of changes in bone mineral density. Clin Endocrinol 1995; 43: 373–382.CrossRef

13.

Berger CE, Kroner AH, Minai-Pour MB, Ogris E, Engel A. Biochemical markers of bone metabolism in bone marrow edema syndrome of the hip. Bone 2003; 33: 346–351.PubMedCrossRef

14.

Parker RK, Ross GJ, Urso JA. Transient osteoporosis of the knee. Skeletal Radiol 1997; 26: 306–309.PubMedCrossRef

15.

Toms AP, Marshall TJ, Becker E, Donell ST, Lobo-Mueller EM, Barker T. Regional migratory osteoporosis: a review illustrated by five cases. Clin Radiol 2005; 60: 425–438.PubMedCrossRef

16.

Horiuchi K, Shiraga N, Fujita N, Yamagishi M, Yabe H. Regional migratory osteoporosis: a case report. J Orthop Sci 2004; 9: 178–181.PubMedCrossRef

17.

Eustace S, Keogh C, Blake M, Ward RJ, Oder PD, Dimasi M. MR imaging of bone oedema: mechanisms and interpretation. Clin Radiol 2001; 56: 4–12.PubMedCrossRef

18.

van de Berg BC, Malghem JJ, Lecouvet FE, Jamart J, Maldague BE. Idiopathic bone marrow edema lesions of the femoral head: predictive value of MR imaging findings. Radiology 1999; 212: 527–535.

19.

Karantanas AH, Drakonaki E, Karachalios T, Korompilias AV, Malizos K. Αcute non-traumatic marrow edema syndrome in the knee: MRI findings at presentation, correlation with spinal DEXA and outcome. Eur J Radiol 2008; 67: 22–33.PubMedCrossRef

20.

Karantanas AH, Nikolakopoulos I, Korompilias AV, Apostolaki E, Skoulikaris N, Eracleous E. Regional migratory osteoporosis in the knee: MRI findings in 22 patients and review of the literature. Eur J Radiol 2008; 67: 34–41.CrossRef

21.

Duncan H, Frame B, Frost H, Arnstein AR. Regional migratory osteoporosis. South Med J 1969; 62: 41–44.PubMed

22.

Doury P. Bone marrow oedema, transient osteoporosis, and algodystrophy. J Bone Jt Surg Br 1994; 776: 993–994.

23.

Lakhanpal S, Ginsburg WW, Luthra HS, Hunder GG. Transient regional osteoporosis. A study of 56 cases and review of the literature. Ann Intern Med 1987; 106: 444–450.PubMed

24.

Fazekas JE, Losada R, Fruauff AA, Ortiz O, Katz DS. Migratory transient osteoporosis of the hip occurring before and during pregnancy. J Women’s Imaging 2002; 4: 80–85.CrossRef

25.

Malizos KN, Zibis AH, Dailiana Z, Hantes M, Karahalios T, Karantanas AH. MR imaging findings in transient osteoporosis of the hip. Eur J Radiol 2004; 50: 238–244.PubMedCrossRef

26.

Massara A, Orzincolo C, Prandini N, Trotta F. Transient regional osteoporosis. Reumatismo 2005; 57: 5–15.PubMed

27.

Hogan CJ, Hurwitz SR. Treatment of complex regional pain syndrome of the lower extremity. J Am Acad Orthop Surg 2002; 10: 281–289.PubMed

28.

Koch E, Hofer HO, Sialer G, Marincek B, von Schulthess GK. Failure of MR imaging to detect reflex sympathetic dystrophy of the extremities. AJR Am J Roentgenol 1991; 156: 113–115.PubMed

29.

Steinberg ME, Steinberg DR. Avascular necrosis of the femoral head. In: Steinberg ME, editor. The hip and its disorders. Philadelphia: W. B. Saunders; 1991. p. 623–47.

30.

Turner DA, Templeton AC, Selzer PM, Rosenberg AG, Petasnick JP. Femoral capital osteonecrosis: MR finding of diffuse marrow abnormalities without focal lesions. Radiology 1989; 171: 135–140.PubMed

31.

Soucacos PN, Xenakis TH, Beris AE, Soucacos PN, Georgoulis A. Idiopathic osteonecrosis of the medial femoral condyle. Classification and treatment. Clin Orthop Relat Res 1997; 341: 82–89.PubMed

32.

Rafii M, Mitnick H, Klug J, Firooznia H. Insufficiency fracture of the femoral head: MR imaging in three patients. AJR Am J Roentgenol 1997; 168: 159–163.PubMed

33.

Kim YM, Oh HC, Kim HJ. The pattern of bone marrow oedema on MRI in osteonecrosis of the femoral head. J Bone Jt Surg Br 2000; 82: 837–841.CrossRef

34.

Fujioka M, Kubo T, Nakamura F, et al. Initial changes of non-traumatic osteonecrosis of femoral head in fat suppression images: bone marrow edema was not found before the appearance of band patterns. Magn Reson Imaging 2001; 19: 985–991.PubMedCrossRef

35.

Kubo T, Yamazoe S, Sugano N, et al. Initial MRI findings of nontraumatic osteonecrosis of the femoral head in renal allograft recipients. Magn Reson Imaging 1997; 15: 1017–1023.PubMedCrossRef

36.

Mitchell DG, Rao VM, Dalinka MK, et al. Femoral head avascular necrosis: correlation of MR imaging, radiographic staging, radionuclide imaging, and clinical findings. Radiology 1987; 162: 709–715.PubMed

37.

Malizos KN, Karantanas AH, Varitimidis SE, et al. Osteonecrosis of the femoral head: etiology, imaging diagnosis and treatment. Eur J Radiol 2007; 63: 16–28.PubMedCrossRef

38.

Iida S, Harada Y, Shimizu K, et al. Correlation between bone marrow edema and collapse of the femoral head in steroid-induced osteonecrosis. AJR Am J Roentgenol 2000; 174: 735–743.PubMed

39.

Ito H, Matsuno T, Minami A. Relationship between bone marrow edema and development of symptoms in patients with osteonecrosis of the femoral head. AJR Am J Roentgenol 2006; 186: 1761–1770.PubMedCrossRef

40.

Karantanas AH. Acute bone marrow edema of the hip: role of MR imaging. Eur Radiol 2007; 17: 2225–2236.PubMedCrossRef

41.

James SLJ, Panicek DM, Davies AM. Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol 2008; 67:11–21.CrossRef

42.

Kim HK, Randall TS, Bian H, Jenkins J, Garces A, Bauss F. Ibandronate for prevention of femoral head deformity after ischemic necrosis of the capital femoral epiphysis in immature pigs. J Bone Jt Surg Am 2005; 87: 550–557.CrossRef

43.

Varenna M, Zucchi F, Binelli L, Failoni S, Gallazzi M, Siniqaqlia L. Intravenous pamidronate in the treatment of transient osteoporosis of the hip. Bone 2002; 31: 96–101.PubMedCrossRef

44.

Aigner N, Petje G, Steinboeck G, Schneider W, Krasny C, Landsiedl F. Treatment of bone-marrow oedema of the talus with the prostacyclin analogue iloprost. An MRI-controlled investigation of a new method. J Bone Jt Surg Br 2001; 83: 855–858.CrossRef

Titel: Bone marrow edema syndrome
verfasst von: Anastasios V. Korompilias
Apostolos H. Karantanas
Marios G. Lykissas
Alexandros E. Beris
Publikationsdatum: 01.05.2009
Verlag: Springer-Verlag
Erschienen in: Skeletal Radiology / Ausgabe 5/2009
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-008-0529-1

Neu im Fachgebiet Radiologie

23.04.2024 | Pankreaskarzinom | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Bone marrow edema syndrome

Abstract

Neu im Fachgebiet Radiologie

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Radiologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2009

Dual-time point PET/CT with F-18 FDG for the differentiation of malignant and benign bone lesions

Synovial fold of the posterior shoulder joint capsule

Transient medial patellar dislocation: injury patterns at US and MR imaging

Osteoarthritis revisited—again!

Can T2 relaxation values and color maps be used to detect chondral damage utilizing subchondral bone marrow edema as a marker?

Magnetic resonance image segmentation using semi-automated software for quantification of knee articular cartilage—initial evaluation of a technique for paired scans

Neu im Fachgebiet Radiologie

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Radiologie