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Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: an unusual morphological appearance

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Abstract

Phosphaturic mesenchymal tumor (PMT) is a rare and distinctive tumor almost always associated with oncogenic osteomalacia. This tumor is often misdiagnosed due to its widely varied histomorphological spectrum. More recently the term PMT or its variants has been used whatever the histomorphological features. Herein, we present a case of a 32-year-old woman who presented with a 2-year history of oncogenic osteomalacia. The clinical examination failed to detect any tumor. The F-18 FDG PET scan and subsequent MRI revealed a tumor in the soft tissues of the right popliteal fossa. The histological features resembled a chondromyxoid fibroma (CMF), a feature documented only in two cases so far.

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References

  1. Weiss D, Bar RS, Weidner N, Wener M, Lee F. Oncogenic osteomalacia: strange tumours in strange places. Postgrad Med J. 1985;61:349–55.

    Article  CAS  Google Scholar 

  2. Folpe AL, Fanburg-Smith JC, Billings SD, Bisceglia M, Bertoni F, Cho JY, et al. Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol. 2004;28:1–30.

    Article  Google Scholar 

  3. Park YK, Unni KK, Beabout JW, Hodgson SF. Oncogenic osteomalacia: a clinicopathologic study of 17 bone lesions. J Korean Med Sci. 1994;9:289–98.

    Article  CAS  Google Scholar 

  4. Park JM, Woo YK, Kang MI, Kang CS, Hahn ST. Oncogenic osteomalacia associated with soft tissue chondromyxoid fibroma. Eur J Radiol. 2001;39:69–72.

    Article  CAS  Google Scholar 

  5. Ryan EA, Reiss E. Oncogenous osteomalacia. Review of the world literature of 42 cases and report of two new cases. Am J Med. 1984;77:501–12.

    Article  CAS  Google Scholar 

  6. Crouzet J, Mimoune H, Beraneck L, Juan LH. Hypophosphatemic osteomalacia with plantar neurilemoma. A review of the literature (100 cases). Rev Rhum Engl Ed. 1995;62:463–6.

    CAS  PubMed  Google Scholar 

  7. Weidner N, Santa Cruz D. Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets. Cancer. 1987;15(59):1442–54.

    Article  Google Scholar 

  8. Schapira D, Izhak OB, Nachtigal A, Burstein A, Shalom RB, Shagrawi I, et al. Tumor-induced osteomalacia. Semin Arthritis Rheum. 1995;25:35–46.

    Article  CAS  Google Scholar 

  9. Weidner N. Review and update: oncogenic osteomalacia-rickets. Ultrastruct Pathol. 1991;15:317–33.

    Article  CAS  Google Scholar 

  10. Ungari C, Rocchi G, Rinna C, Agrillo A, Lattanzi A, Pagnoni M. Hypophosphaturic mesenchymal tumor of the ethmoid associated with oncogenic osteomalacia. J Craniofac Surg. 2004;15:523–7.

    Article  Google Scholar 

  11. Woo VL, Landesberg R, Imel EA, Singer SR, Folpe AL, Econs MJ, et al. Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:925–32.

    Article  Google Scholar 

  12. Kaylie DM, Jackson CG, Gardner EK. Oncogenic osteomalacia caused by phosphaturic mesenchymal tumor of the temporal bone. Otolaryngol Head Neck Surg. 2006;135:653–4.

    Article  Google Scholar 

  13. Parshwanath HA, Kulkarni PR, Rao R, Joshi SK, Patil P. Phosphaturic mesenchymal tumor of ethmoid sinus. Indian J Pathol Microbiol. 2010;53:384–5.

    Article  CAS  Google Scholar 

  14. Pedrazzoli M, Colletti G, Ferrari M, Rossetti G, Moneghini L, Autelitano L. Mesenchymal phosphaturic neoplasm in the maxillary sinus: a case report. Int J Oral Maxillofac Surg. 2010;39:1027–32.

    Article  CAS  Google Scholar 

  15. Ahn JM, Kim HJ, Cha CM, Kim J, Yim SG, Kim HJ. Oncogenic osteomalacia: induced by tumor, cured by surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:636–41.

    Article  Google Scholar 

  16. Shelekhova KV, Kazakov DV, Michal M. Sinonasal phosphaturic mesenchymal tumor (mixed connective tissue variant): report of 2 cases. Am J Surg Pathol. 2010;34:596–7.

    Article  Google Scholar 

  17. Beech TJ, Rokade A, Gittoes N, Johnson AP. A haemangiopericytoma of the ethmoid sinus causing oncogenic osteomalacia: a case report and review of the literature. Int J Oral Maxillofac Surg. 2007;36(10):956–8.

    Article  CAS  Google Scholar 

  18. David K, Revesz T, Kratimenos G, Krausz T, Crockard HA. Oncogenic osteomalacia associated with a meningeal phosphaturic mesenchymal tumor. Case report. J Neurosurg. 1996;84:288–92.

    Article  CAS  Google Scholar 

  19. Nitzan DW, Horowitz AT, Darmon D, Friedlaender MM, Rubinger D, Stein P, et al. Oncogenous osteomalacia: a case study. Bone Miner. 1989;6:191–7.

    Article  CAS  Google Scholar 

  20. Jan de Beur SM. Tumor-induced osteomalacia. JAMA. 2005;14(294):1260–7.

    Article  Google Scholar 

  21. Roarke MC, Nguyen BD. PET/CT localization of phosphaturic mesenchymal neoplasm causing tumor-induced osteomalacia. Clin Nucl Med. 2007;32:300–1.

    Article  Google Scholar 

  22. Jan de Beur SM, Streeten EA, Civelek AC, McCarthy EF, Uribe L, Marx SJ, et al. Localisation of mesenchymal tumours by somatostatin receptor imaging. Lancet. 2002;359:761–3.

    Article  CAS  Google Scholar 

  23. Kumar R. Tumor-induced osteomalacia and the regulation of phosphate homeostasis. Bone. 2000;27:333–8.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Tata Memorial Hospital, E. Borges Marg, Parel, Mumbai, 400 012, India

    Pallavi Suryawanshi, Rahul Dhake, Saral Desai, Bharat Rekhi & Nirmala Ajit Jambhekar

  2. Department of Orthopaedic Surgery, Tata Memorial Hospital, Mumbai, India

    Manish Agarwal & Kishor B. Reddy

Authors
  1. Pallavi Suryawanshi
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  2. Manish Agarwal
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  3. Rahul Dhake
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  4. Saral Desai
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  5. Bharat Rekhi
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  6. Kishor B. Reddy
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  7. Nirmala Ajit Jambhekar
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Correspondence to Nirmala Ajit Jambhekar.

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Suryawanshi, P., Agarwal, M., Dhake, R. et al. Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: an unusual morphological appearance. Skeletal Radiol 40, 1481–1485 (2011). https://doi.org/10.1007/s00256-011-1159-6

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  • DOI: https://doi.org/10.1007/s00256-011-1159-6

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