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Erschienen in: Skeletal Radiology 10/2012

01.10.2012 | Scientific Article

Enchondromas in children: imaging appearance with pathological correlation

verfasst von: Guillaume Bierry, Darcy A. Kerr, G. Petur Nielsen, Andrew E. Rosenberg, Ambrose J. Huang, Martin Torriani, Miriam A. Bredella

Erschienen in: Skeletal Radiology | Ausgabe 10/2012

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Abstract

Objective

Enchondromas are benign lesions that may present with nonspecific features on imaging in children. Correlation of histology with imaging findings is often required to make the final diagnosis of a benign lesion. The aim of this study was to review imaging and pathological findings of enchondromas in children.

Materials and methods

Imaging examinations of 12 enchondromas in 11 patients (median age 14 years) were retrospectively reviewed. Imaging evaluation included an assessment of lesion size, relationship to the growth plate, mineralization, matrix and periosteal reaction, intrinsic MR signal characteristics, and intraosseous and soft-tissue edema. Pathological findings were reviewed.

Results

Lesions were located in the phalanx in 33% (4 out of 12), metacarpal in 25% (3 out of 12), femur in 33% (4 out of 12) and tibia in 8% cases (1 out of 12). The mean size was 28 mm (range, 11–70 mm). Matrix mineralization in a typical “rings-and-arcs” pattern was observed in 20% of the lesions with available radiographs/CT (2 out of 10). Lesions were expansive with endosteal scalloping in 75% of cases (9 out 12) and contacted the growth plate in 50% of cases (6 out of 12). All enchondromas in which MR imaging was available (5 out of 5) demonstrated typical cartilaginous matrix of lobules of high T2 signal, low T1 signal, and peripheral enhancement.

Conclusion

Enchondromas in children are relatively large lesions, with frequent endosteal scalloping and rare matrix mineralization.
Literatur
1.
Zurück zum Zitat Adler CP, Kozlowski K. Primary bone tumors and tumorous conditions in children. Berlin Heidelberg New York: Springer; 1993.CrossRef Adler CP, Kozlowski K. Primary bone tumors and tumorous conditions in children. Berlin Heidelberg New York: Springer; 1993.CrossRef
2.
Zurück zum Zitat Van den Berg H, Slaar A, Kroon HM, Taminiau AHM, Hogendoorn P. Results of diagnostic review in pediatric bone tumors and tumorlike lesions. J Pediatr Orthop. 2008;28:561–4.PubMedCrossRef Van den Berg H, Slaar A, Kroon HM, Taminiau AHM, Hogendoorn P. Results of diagnostic review in pediatric bone tumors and tumorlike lesions. J Pediatr Orthop. 2008;28:561–4.PubMedCrossRef
3.
Zurück zum Zitat Parkin DM, Stiller CA, Draper GJ, Bieber CA. The international incidence of childhood cancer. Int J Cancer. 1988;42:511–20.PubMedCrossRef Parkin DM, Stiller CA, Draper GJ, Bieber CA. The international incidence of childhood cancer. Int J Cancer. 1988;42:511–20.PubMedCrossRef
4.
Zurück zum Zitat Dorfman H, Czerniak B. Bone tumors. Philadelphia: Mosby; 1998. Dorfman H, Czerniak B. Bone tumors. Philadelphia: Mosby; 1998.
5.
Zurück zum Zitat Unni K. Dahlin’s bone tumors: general aspects and data on 11,087 cases. Philadelphia: Lippincott-Raven; 1996. Unni K. Dahlin’s bone tumors: general aspects and data on 11,087 cases. Philadelphia: Lippincott-Raven; 1996.
6.
Zurück zum Zitat Murphey MD, Flemming DJ, Boyea SR, et al. Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features. Radiographics. 1998;18:1213–37.PubMed Murphey MD, Flemming DJ, Boyea SR, et al. Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features. Radiographics. 1998;18:1213–37.PubMed
7.
Zurück zum Zitat Biermann JS. Common benign lesions of bone in children and adolescents. J Pediatr Orthop. 2002;22:268–73.PubMedCrossRef Biermann JS. Common benign lesions of bone in children and adolescents. J Pediatr Orthop. 2002;22:268–73.PubMedCrossRef
8.
Zurück zum Zitat Jaffe HL, Lichtenstein L. Solitary benign enchondroma of bone. Arch Surg. 1943;46:480–93.CrossRef Jaffe HL, Lichtenstein L. Solitary benign enchondroma of bone. Arch Surg. 1943;46:480–93.CrossRef
9.
Zurück zum Zitat Amary MF, Bacsi K, Maggiani F, et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol. 2011;224:334–43.PubMedCrossRef Amary MF, Bacsi K, Maggiani F, et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol. 2011;224:334–43.PubMedCrossRef
10.
Zurück zum Zitat Walden MJ, Murphey MD, Vidal JA. Incidental enchondromas of the knee. AJR Am J Roentgenol. 2008;190:1611–5.PubMedCrossRef Walden MJ, Murphey MD, Vidal JA. Incidental enchondromas of the knee. AJR Am J Roentgenol. 2008;190:1611–5.PubMedCrossRef
11.
Zurück zum Zitat Cawte TG, Steiner GC, Beltran J, Dorfman HD. Chondrosarcoma of the short tubular bones of the hands and feet. Skelet Radiol. 1998;27:625–32.CrossRef Cawte TG, Steiner GC, Beltran J, Dorfman HD. Chondrosarcoma of the short tubular bones of the hands and feet. Skelet Radiol. 1998;27:625–32.CrossRef
12.
Zurück zum Zitat Kendell SD, Collins MS, Adkins MC, Sundaram M, Unni KK. Radiographic differentiation of enchondroma from low-grade chondrosarcoma in the fibula. Skelet Radiol. 2004;33:458–66.CrossRef Kendell SD, Collins MS, Adkins MC, Sundaram M, Unni KK. Radiographic differentiation of enchondroma from low-grade chondrosarcoma in the fibula. Skelet Radiol. 2004;33:458–66.CrossRef
13.
Zurück zum Zitat Bui KL, Ilaslan H, Bauer TW, et al. Cortical scalloping and cortical penetration by small eccentric chondroid lesions in the long tubular bones: not a sign of malignancy? Skelet Radiol. 2009;38:791–6.CrossRef Bui KL, Ilaslan H, Bauer TW, et al. Cortical scalloping and cortical penetration by small eccentric chondroid lesions in the long tubular bones: not a sign of malignancy? Skelet Radiol. 2009;38:791–6.CrossRef
14.
Zurück zum Zitat Hasegawa T, Seki K, Yang P, et al. Differentiation and proliferative activity in benign and malignant cartilage tumors of bone. Hum Pathol. 1995;26:838–45.PubMedCrossRef Hasegawa T, Seki K, Yang P, et al. Differentiation and proliferative activity in benign and malignant cartilage tumors of bone. Hum Pathol. 1995;26:838–45.PubMedCrossRef
15.
Zurück zum Zitat Wootton-Gorges SL. MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am. 2009;17:469–87.PubMedCrossRef Wootton-Gorges SL. MR imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imaging Clin N Am. 2009;17:469–87.PubMedCrossRef
16.
Zurück zum Zitat Amling M, Werner M, Pösl M, et al. Calcifying solitary bone cyst: morphological aspects and differential diagnosis of sclerotic bone tumours. Virchows Arch. 1995;426:235–42.PubMedCrossRef Amling M, Werner M, Pösl M, et al. Calcifying solitary bone cyst: morphological aspects and differential diagnosis of sclerotic bone tumours. Virchows Arch. 1995;426:235–42.PubMedCrossRef
17.
Zurück zum Zitat Schmit P, Glorion C. Osteomyelitis in infants and children. Eur Radiol. 2004;14(Suppl 4):L44–54.PubMed Schmit P, Glorion C. Osteomyelitis in infants and children. Eur Radiol. 2004;14(Suppl 4):L44–54.PubMed
18.
Zurück zum Zitat Sailhan F, Chotel F, Parot R. Chondroblastoma of bone in a pediatric population. J Bone Joint Surg Br. 2009;91:2159–68.CrossRef Sailhan F, Chotel F, Parot R. Chondroblastoma of bone in a pediatric population. J Bone Joint Surg Br. 2009;91:2159–68.CrossRef
Metadaten
Titel
Enchondromas in children: imaging appearance with pathological correlation
verfasst von
Guillaume Bierry
Darcy A. Kerr
G. Petur Nielsen
Andrew E. Rosenberg
Ambrose J. Huang
Martin Torriani
Miriam A. Bredella
Publikationsdatum
01.10.2012
Verlag
Springer-Verlag
Erschienen in
Skeletal Radiology / Ausgabe 10/2012
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-012-1377-6

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