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European Journal of Nuclear Medicine and Molecular Imaging

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01.05.2004 | Original Article

Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with ¹⁵O-labelled carbon dioxide or water, carbon monoxide and oxygen: a multicentre study in Japan

verfasst von: Hiroshi Ito, Iwao Kanno, Chietsugu Kato, Toshiaki Sasaki, Kenji Ishii, Yasuomi Ouchi, Akihiko Iida, Hidehiko Okazawa, Kohei Hayashida, Naohiro Tsuyuguchi, Kazunari Ishii, Yasuo Kuwabara, Michio Senda

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 5/2004

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Abstract

Measurement of cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO₂) by positron emission tomography (PET) with oxygen-15 labelled carbon dioxide (C¹⁵O₂) or ¹⁵O-labelled water (H₂ ¹⁵O), ¹⁵O-labelled carbon monoxide (C¹⁵O) and ¹⁵O-labelled oxygen (¹⁵O₂) is useful for diagnosis and treatment planning in cases of cerebrovascular disease. The measured values theoretically depend on various factors, which may differ between PET centres. This study explored the applicability of a database of ¹⁵O-PET by examining between-centre and within-centre variation in values. Eleven PET centres participated in this multicentre study; seven used the steady-state inhalation method, one used build-up inhalation and three used bolus administration of C¹⁵O₂ (or H₂ ¹⁵O) and ¹⁵O₂. All used C¹⁵O for measurement of CBV. Subjects comprised 70 healthy volunteers (43 men and 27 women; mean age 51.8±15.1 years). Overall mean±SD values for cerebral cortical regions were: CBF=44.4±6.5 ml 100 ml⁻¹ min⁻¹; CBV=3.8±0.7 ml 100 ml⁻¹; OEF=0.44±0.06; CMRO₂=3.3±0.5 ml 100 ml⁻¹ min⁻¹. Significant between-centre variation was observed in CBV, OEF and CMRO₂ by one-way analysis of variance. However, the overall inter-individual variation in CBF, CBV, OEF and CMRO₂ was acceptably small. Building a database of normal cerebral haemodynamics obtained by the¹⁵O-PET methods may be practicable.

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Titel: Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 15O-labelled carbon dioxide or water, carbon monoxide and oxygen: a multicentre study in Japan
verfasst von: Hiroshi Ito
Iwao Kanno
Chietsugu Kato
Toshiaki Sasaki
Kenji Ishii
Yasuomi Ouchi
Akihiko Iida
Hidehiko Okazawa
Kohei Hayashida
Naohiro Tsuyuguchi
Kazunari Ishii
Yasuo Kuwabara
Michio Senda
Publikationsdatum: 01.05.2004
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 5/2004
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-003-1430-8

Springer Medizin

Abstract

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