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Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 3/2005

01.03.2005 | Review Article

Genetic and epigenetic features in radiation sensitivity

Part II: implications for clinical practice and radiation protection

verfasst von: Michel H. Bourguignon, Pablo A. Gisone, Maria R. Perez, Severino Michelin, Diana Dubner, Marina Di Giorgio, Edgardo D. Carosella

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 3/2005

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Abstract

Recent progress especially in the field of gene identification and expression has attracted greater attention to the genetic and epigenetic susceptibility to cancer, possibly enhanced by ionising radiation. This issue is especially important for radiation therapists since hypersensitive patients may suffer from adverse effects in normal tissues following standard radiation therapy, while normally sensitive patients could receive higher doses of radiation, offering a better likelihood of cure for malignant tumours. Although only a small percentage of individuals are “hypersensitive” to radiation effects, all medical specialists using ionising radiation should be aware of the aforementioned progress in medical knowledge. The present paper, the second of two parts, reviews human disorders known or strongly suspected to be associated with hypersensitivity to ionising radiation. The main tests capable of detecting such pathologies in advance are analysed, and ethical issues regarding genetic testing are considered. The implications for radiation protection of possible hypersensitivity to radiation in a part of the population are discussed, and some guidelines for nuclear medicine professionals are proposed.
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Metadaten
Titel
Genetic and epigenetic features in radiation sensitivity
Part II: implications for clinical practice and radiation protection
verfasst von
Michel H. Bourguignon
Pablo A. Gisone
Maria R. Perez
Severino Michelin
Diana Dubner
Marina Di Giorgio
Edgardo D. Carosella
Publikationsdatum
01.03.2005
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 3/2005
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-004-1731-6

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