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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.10.2005 | Original Article

Early restaging whole-body ¹⁸F-FDG PET during induction chemotherapy predicts clinical outcome in patients with locoregionally advanced nasopharyngeal carcinoma

verfasst von: Ruoh-Fang Yen, Tony Hsiu-Hsi Chen, Lai-Lei Ting, Kai-Yuan Tzen, Mei-Hsiu Pan, Ruey-Long Hong

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2005

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Abstract

Purpose

This study was undertaken to evaluate the utility of whole-body ¹⁸F-FDG PET in monitoring therapeutic effect during induction chemotherapy (IC) and in predicting prognosis in patients with locoregionally advanced nasopharyngeal carcinoma (NPC).

Methods

Fifty patients who had histologically proven, locoregionally advanced NPC without distant metastasis and had received IC were recruited in this study. The study cohort consisted of 19 females and 31 males (age 17–72 years, mean 45.9±11.9). Whole-body ¹⁸F-FDG PET was performed in each patient after completion of one (33 patients) or two (17 patients) courses of IC. Each patient was restaged on the basis of the ¹⁸F-FDG PET results. Patients who were downstaged to stage I or II were classified as major responders; the rest were classified as non-major responders.

Results

Only 1 of the 23 major responders subsequently developed local recurrence. At the time of data analysis, all major responders were alive; by contrast, of the 27 non-major responders, 15 had locoregional recurrence or distant metastasis and nine had died (seven of NPC and two of treatment-related complications). Kaplan-Meier survival analysis showed significantly longer recurrence-free survival and overall survival in major responders (56.4±9.2 and 58.1±2.2 months) as compared with non-major responders (33.7±23.2 and 44.7±20.0 months), with p<0.0001 and p=0.0024, respectively.

Conclusion

The results of this study suggest that early restaging by a single whole-body ¹⁸F-FDG PET scan after the first or second course of IC is useful for predicting therapeutic response and outcome in patients with locoregionally advanced NPC.

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Titel: Early restaging whole-body 18F-FDG PET during induction chemotherapy predicts clinical outcome in patients with locoregionally advanced nasopharyngeal carcinoma
verfasst von: Ruoh-Fang Yen
Tony Hsiu-Hsi Chen
Lai-Lei Ting
Kai-Yuan Tzen
Mei-Hsiu Pan
Ruey-Long Hong
Publikationsdatum: 01.10.2005
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2005
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-005-1837-5

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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