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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.07.2006

Is 3′-deoxy-3′-¹⁸F-fluorothymidine a better marker for tumour response than ¹⁸F-fluorodeoxyglucose?

verfasst von: Sven N. Reske, Sandra Deisenhofer

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Sonderheft 1/2006

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Abstract

3′-Deoxy-3′-¹⁸F-fluorothymidine (FLT) was developed in 1998 by Shields and co-workers because monitoring of treatment response would be facilitated by imaging agents able to provide measures of tissue and tumour proliferation. Since then, FLT metabolism has been clarified in more detail in cell culture and experimental animal tumour models and also in clinical studies. Recently, FLT has increasingly been used for the assessment of response to anticancer treatment, mainly in tumour xenograft SCID mouse models; in contrast, clinical data are scarce. In this article we briefly summarise the intermediary metabolism of FLT and its application as an anticancer treatment response probe. The potential value and limitations of FLT as a highly promising proliferation imaging probe and its use for monitoring of treatment response are discussed.

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Titel: Is 3′-deoxy-3′-18F-fluorothymidine a better marker for tumour response than 18F-fluorodeoxyglucose?
verfasst von: Sven N. Reske
Sandra Deisenhofer
Publikationsdatum: 01.07.2006
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe Sonderheft 1/2006
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-006-0134-2

Springer Medizin

Abstract

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