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European Journal of Nuclear Medicine and Molecular Imaging

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01.09.2008 | Original Article

Regional wall thickening in gated myocardial perfusion SPECT in a Japanese population: effect of sex, radiotracer, rotation angles and frame rates

verfasst von: Nasima Akhter, Kenichi Nakajima, Koichi Okuda, Shinro Matsuo, Tatsuya Yoneyama, Junichi Taki, Seigo Kinuya

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 9/2008

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Abstract

Purpose

Gated single-photon emission computed tomography (SPECT) imaging of myocardium by ^99mTc and ²⁰¹Tl is used extensively to measure quantitative cardiac functional parameters. However, factors affecting normal values for myocardial functional parameters and population-specific standards have not yet been established. The aim of the study was to determine the effect of sex, radiotracer, rotation angles and frame rates on resting myocardial wall thickening (WT) and to develop a Japanese standard of normal values for WT.

Methods

Data from a total of 202 patients with low possibility of having cardiac problems were collected from nine hospitals throughout Japan. Patients were divided into five groups according to study protocol, and WT was evaluated according to the 17-segment and four-region (basal, mid and apical regions and the apex) polar map distribution.

Result

WT was generally higher in women than in men irrespective of the use of radiotracers, rotation angles or frame rates, and the difference was highly significant in the mid and apical regions. In any protocol used, resting myocardial thickening in the apex was higher than in the mid and apical regions, and thickening was lowest in the basal region, suggesting heterogeneous regional myocardial thickening (%) in normal subjects. Different rotation angles showed no significant change on WT, but different frame rates and tracers showed significant WT change in both sexes. Percent thickening of the myocardium was significantly higher in imaging by ^99mTc-labelled tracers than in ²⁰¹Tl.

Conclusion

Sex, radiotracers and frame rates had a significant effect on myocardial thickening, and the importance of population-specific standards should be emphasized. A normal database can serve as a standard for gated SPECT evaluation of myocardial thickening in a Japanese population and might be applicable to Asian populations having a similar physique.

Shen MY, Liu YH, Sinusas AJ, Fetterman R, Bruni W, Drozhinin OE, et al. Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging. J Nucl Cardiol 1999;6:583–95.PubMedCrossRef

Ababneh AA, Sciacca RR, Kim B, Bergmann SR. Normal limits for left ventricular ejection fraction and volumes estimated with gated myocardial perfusion imaging in patients with normal exercise test results: influence of tracer, gender, and acquisition camera. J Nucl Cardiol 2000;7:661–8.PubMedCrossRef

De Bondt P, Van de Wiele C, De Sutter J, De Winter F, De Backer G, Dierckx RA. Age- and gender-specific differences in left ventricular cardiac function and volumes determined by gated SPET. Eur J Nucl Med 2001;28:620–4.PubMedCrossRef

Nakajima K, Kusuoka H, Nishimura S, Yamashina A, Nishimura T. Normal limits of ejection fraction and volumes determined by gated SPECT in clinically normal patients without cardiac events: a study based on the J-ACCESS database. Eur J Nucl Med Mol Imaging 2007;34:1088–96.PubMedCrossRef

Clark AN, Beller GA. The present role of nuclear cardiology in clinical practice. Q J Nucl Med Mol Imaging 2005;49:43–58.PubMed

Wahba FF, Lamb HJ, Bax JJ, Dibbets-Schneider P, Bavelaar-Croon CD, Zwinderman AH, et al. Assessment of regional myocardial wall motion and thickening by gated 99Tcm-tetrofosmin SPECT: a comparison with magnetic resonance imaging. Nucl Med Commun 2001;22:663–71.PubMedCrossRef

Kurihara H, Nakamura S, Hatada K, Takehana K, Hamada S, Watanabe J, et al. Early prediction of regional functional recovery in reperfused myocardium using single-injection resting quantitative electrocardiographic gated SPET. Eur J Nucl Med Mol Imaging 2002;29:458–64.PubMedCrossRef

Taki J, Higuchi T, Nakajima K, Matsunari I, Hwang EH, Bunko H, et al. Electrocardiographic gated ^99mTc-MIBI SPECT for functional assessment of patients after coronary artery bypass surgery: comparison of wall thickening and wall motion analysis. J Nucl Med 2002;43:589–95.PubMed

Murashita T, Makino Y, Kamikubo Y, Yasuda K, Mabuchi M, Tamaki N. Quantitative gated myocardial perfusion single photon emission computed tomography improves the prediction of regional functional recovery in akinetic areas after coronary bypass surgery: useful tool for evaluation of myocardial viability. J Thorac Cardiovasc Surg 2003;126:1328–34.PubMedCrossRef

10.

Mabuchi M, Kubo N, Morita K, Makino Y, Matsui Y, Murashita T, et al. Prediction of functional recovery after coronary bypass surgery using quantitative gated myocardial perfusion SPECT. Nucl Med Commun 2003;24:625–31.PubMedCrossRef

11.

Nakajima K, Kumita S, Ishida Y, Momose M, Hashimoto J, Morita K, et al. Creation and characterization of Japanese standards for myocardial perfusion SPECT: database from the Japanese Society of Nuclear Medicine Working Group. Ann Nucl Med 2007;21:505–11.PubMedCrossRef

12.

Germano G, Erel J, Lewin H, Kavanagh PB, Berman DS. Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol 1997;30:1360–7.PubMedCrossRef

13.

Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. J Nucl Cardiol 2002;9:240–5.PubMedCrossRef

14.

Shirakawa S, Hattori N, Tamaki N, Fujita T, Yano S, Kudoh T, et al. Assessment of left ventricular wall thickening with gated 99mTc-MIBI SPECT—value of normal file (in Japanese). Kaku Igaku (Jpn J Nucl Med) 1995;32:643–50.

15.

Adachi I, Morita K, Imran MB, Konno M, Mochizuki T, Kubo N, et al. Heterogeneity of myocardial wall motion and thickening in the left ventricle evaluated with quantitative gated SPECT. J Nucl Cardiol 2000;7:296–300.PubMedCrossRef

16.

Sharir T, Berman DS, Waechter PB, Areeda J, Kavanagh PB, Gerlach J, et al. Quantitative analysis of regional motion and thickening by gated myocardial perfusion SPECT: normal heterogeneity and criteria for abnormality. J Nucl Med 2001;42:1630–8.PubMed

17.

Germano G, Erel J, Kiat H, Kavanagh PB, Berman DS. Quantitative LVEF and qualitative regional function from gated thallium-201 perfusion SPECT. J Nucl Med 1997;38:749–54.PubMed

18.

Germano G, Kavanagh PB, Waechter P, Areeda J, Van Kriekinge S, Sharir T, et al. A new algorithm for the quantitation of myocardial perfusion SPECT. I: technical principles and reproducibility. J Nucl Med 2000;41:712–9.PubMed

19.

Nakajima K, Taki J, Higuchi T, Kawano M, Taniguchi M, Maruhashi K, et al. Gated SPET quantification of small hearts: mathematical simulation and clinical application. Eur J Nucl Med 2000;27:1372–9.PubMedCrossRef

20.

Hambye AS, Vervaet A, Dobbeleir A. Variability of left ventricular ejection fraction and volumes with quantitative gated SPECT: influence of algorithm, pixel size and reconstruction parameters in small and normal-sized hearts. Eur J Nucl Med Mol Imaging 2004;31:1606–13.PubMedCrossRef

Titel: Regional wall thickening in gated myocardial perfusion SPECT in a Japanese population: effect of sex, radiotracer, rotation angles and frame rates
verfasst von: Nasima Akhter
Kenichi Nakajima
Koichi Okuda
Shinro Matsuo
Tatsuya Yoneyama
Junichi Taki
Seigo Kinuya
Publikationsdatum: 01.09.2008
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 9/2008
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-0804-3

Springer Medizin

Abstract

Purpose

Methods

Result

Conclusion

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