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European Journal of Nuclear Medicine and Molecular Imaging

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01.07.2009 | Original Article

Effects of medial temporal lobe degeneration on brain perfusion in amnestic MCI of AD type: deafferentation and functional compensation?

verfasst von: Eric Guedj, Emmanuel J. Barbeau, Mira Didic, Olivier Felician, Catherine de Laforte, Jean-Philippe Ranjeva, Michel Poncet, Patrick J. Cozzone, Olivier Mundler, Mathieu Ceccaldi

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 7/2009

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Abstract

Purpose

Cortical atrophy is correlated with the progression of neuropathological lesions within the medial temporal lobes (MTL) in Alzheimer’s disease (AD). Our aim was to determine which local and remote functional changes result from MTL volume loss at the predementia stage.

Methods

We studied the relationship between entorhinal and hippocampal MR volumes and whole-brain SPECT perfusion via a voxel-based correlative analysis in 19 patients with amnestic mild cognitive impairment with a memory profile suggestive of early AD.

Results

Right MTL volumes were positively correlated with remote posterior perfusion of the posterior cingulate cortex, and negatively correlated with remote anterior perfusion of the right medial and dorsolateral prefrontal cortex. There was no local correlation between volumes and perfusion within the MTL.

Conclusion

These findings provide further insight into functional changes that result from MTL volume loss during the predementia stage of AD. The positive correlation between MTL volumes and posterior cingulate perfusion may reflect the deafferentation of a temporocingulate network due to mediotemporal degeneration. The paradoxical negative correlation between MTL volumes and prefrontal perfusion may result from recruitment of an alternative anterior temporofrontal network. It remains to be investigated how the “net sum” of this perfusion modulation affects memory and other cognitive domains through a possible compensatory perspective.

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Titel: Effects of medial temporal lobe degeneration on brain perfusion in amnestic MCI of AD type: deafferentation and functional compensation?
verfasst von: Eric Guedj
Emmanuel J. Barbeau
Mira Didic
Olivier Felician
Catherine de Laforte
Jean-Philippe Ranjeva
Michel Poncet
Patrick J. Cozzone
Olivier Mundler
Mathieu Ceccaldi
Publikationsdatum: 01.07.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 7/2009
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1060-x

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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