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European Journal of Nuclear Medicine and Molecular Imaging

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01.06.2009 | Original Article

The value of FDG-PET/CT in assessing single pulmonary nodules in patients at high risk of lung cancer

verfasst von: Olga Kagna, Anna Solomonov, Zohar Keidar, Rachel Bar-Shalom, Oren Fruchter, Mordechai Yigla, Ora Israel, Luda Guralnik

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2009

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Abstract

Purpose

To evaluate whether PET/low-dose CT (ldCT) using ¹⁸F-fluorodeoxyglucose (FDG) improves characterization of indeterminate single pulmonary nodules (SPNs) in patients at high risk of lung cancer.

Methods

Retrospective analysis of 307 patients who underwent FDG-PET/CT for indeterminate SPNs identified 93 (70 men, age range 46–90 years) at high risk of lung cancer (age >40 years, minimum 10 pack-year smokers). SPNs were evaluated for the presence and intensity of FDG avidity and ldCT patterns. The performance of visual and semiquantitative FDG-PET/ldCT algorithms for characterization of SPNs was compared to that of ldCT. Incongruent FDG-PET and ldCT patterns were analyzed for significance in further patient management.

Results

Malignancy was diagnosed in 38% patients. FDG avidity defined 33 SPNs as true-positive (TP) and 2 as false-negative (FN) (malignant), and 41 as true-negative (TN) and 17 as false-positive (FP) (benign). For SUVmax of 2.2 (by ROC analysis) there were 27 TP, 8 FN, 48 TN and 10 FP SPNs. LdCT defined 34 TP, 1 FN, 28 TN and 30 FP lesions. Of the FP lesions on ldCT, 60% were FDG-negative. Visual PET/ldCT analysis had a sensitivity of 94%, a specificity of 70%, an accuracy of 80%, a positive predictive value (PPV) of 66%, and a negative predictive value (NPV) of 95% as compared to 77%, 83%, 81%, 73%, 86% for semiquantitative PET/ldCT and 97%, 48%, 66%, 53%, 96% for ldCT, respectively. Both PET/ldCT algorithms had statistically significantly higher specificity and accuracy than ldCT. Semiquantitative analysis showed significantly higher PPV and lower sensitivity and NPV than found with ldCT.

Conclusion

A single screening procedure encompassing FDG-PET and ldCT may improve screening for lung cancer in high-risk patients. The significantly improved specificity may potentially reduce FP ldCT results and further unnecessary invasive procedures.

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Titel: The value of FDG-PET/CT in assessing single pulmonary nodules in patients at high risk of lung cancer
verfasst von: Olga Kagna
Anna Solomonov
Zohar Keidar
Rachel Bar-Shalom
Oren Fruchter
Mordechai Yigla
Ora Israel
Luda Guralnik
Publikationsdatum: 01.06.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2009
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1061-9

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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