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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.03.2009

Pre-clinical PET/MR: technological advances and new perspectives in biomedical research

verfasst von: Hans F. Wehrl, Martin S. Judenhofer, Stefan Wiehr, Bernd J. Pichler

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Sonderheft 1/2009

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Abstract

Introduction

Combined PET/MRI allows for multi-parametric imaging and reveals one or more functional processes simultaneously along with high-resolution morphology. Especially in small-animal research, where high soft tissue contrast is required, and the scan time as well as radiation dose are critical factors, the combination of PET and MRI would be beneficial compared with PET/CT.

Development

In the mid-1990’s, several research groups used different approaches to integrate PET detectors into high-field MRI. First, systems were based on optical fibres guiding the scintillation light to the PMT’s, which reside outside the fringe magnetic field. Recent advances in gamma ray detector technology, which were initiated mainly by the advent of avalanche photodiodes (APD’s) as well as the routine availability of fast scintillation materials like lutetium oxyorthosilicate (LSO), paved the way towards the development of fully magnetic-field-insensitive high-performance PET detectors.

Technology

Current animal PET/MR technologies are reviewed and pitfalls when engineering a full integration of a PET and a high-field MRI are discussed. Compact PET detectors can be integrated in small-bore, high-field MRI tomographs. Detailed performance evaluations have shown that the mutual interference between the two imaging systems could be minimized. The performance of all major MR applications, ranging from T1- or T2-weighted imaging up to echo-planar imaging (EPI) for functional MRI (fMRI) or magnetic resonance spectroscopy (MRS), could be maintained, even when the PET insert was built into the MRI and acquiring PET data simultaneously. Similarly, the PET system performance was not influenced by the static magnetic field or applied MRI sequences.

Applications

Initial biomedical research applications range from the combination of functional information from PET with the anatomical information from the MRI to multi-functional imaging combining metabollic PET and MRI data.

Discussion

Compared to other multi-modality approaches PET/MR offers a multitude of complementary function and anatomical information. The ability to obtain simultaneous PET and MRI data with this new imaging modality could have tremendous impact on small animal imaging research.

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Titel: Pre-clinical PET/MR: technological advances and new perspectives in biomedical research
verfasst von: Hans F. Wehrl
Martin S. Judenhofer
Stefan Wiehr
Bernd J. Pichler
Publikationsdatum: 01.03.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe Sonderheft 1/2009
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1078-0

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Pre-clinical PET/MR: technological advances and new perspectives in biomedical research

Abstract

Introduction

Development

Technology

Applications

Discussion

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Introduction

Development

Technology

Applications

Discussion

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