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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.01.2013 | Original Article

Dosimetry of ²²³Ra-chloride: dose to normal organs and tissues

verfasst von: Michael Lassmann, Dietmar Nosske

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 2/2013

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Abstract

Purpose

²²³Ra-Chloride (also called Alpharadin®) targets bone metastases with short range alpha particles. In recent years several clinical trials have been carried out showing, in particular, the safety and efficacy of palliation of painful bone metastases in patients with castration-resistant prostate cancer using ²²³Ra-chloride. The purpose of this work was to provide a comprehensive dosimetric calculation of organ doses after intravenous administration of ²²³Ra-chloride according to the present International Commission on Radiological Protection (ICRP) model for radium.

Methods

Absorbed doses were calculated for 25 organs or tissues.

Results

Bone endosteum and red bone marrow show the highest dose coefficients followed by liver, colon and intestines. After a treatment schedule of six intravenous injections with 0.05 MBq/kg of ²²³Ra-chloride each, corresponding to 21 MBq for a 70 kg patient, the absorbed alpha dose to the bone endosteal cells is about 16 Gy and the corresponding absorbed dose to the red bone marrow is approximately 1.5 Gy.

Conclusion

The comprehensive list of dose coefficients presented in this work will assist in comparing and evaluating organ doses from various therapy modalities used in nuclear medicine and will provide a base for further development of patient-specific dosimetry.

Developed at the Bundesamt für Strahlenschutz (BfS), Abteilung Strahlenschutz und Gesundheit, 85764 Oberschleißheim, Germany

As proposed by the ICRP in ICRP Publication 103 [16] as the unit for an RBE-weighted absorbed dose for deterministic biological effects

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Titel: Dosimetry of 223Ra-chloride: dose to normal organs and tissues
verfasst von: Michael Lassmann
Dietmar Nosske
Publikationsdatum: 01.01.2013
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 2/2013
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2265-y

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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