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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.07.2013 | Original Article

¹⁸F-FDOPA PET/CT for detection of recurrence in patients with glioma: prospective comparison with ¹⁸F-FDG PET/CT

verfasst von: Sellam Karunanithi, Punit Sharma, Abhishek Kumar, Bangkim Chandra Khangembam, Guru Pada Bandopadhyaya, Rakesh Kumar, Deepak Kumar Gupta, Arun Malhotra, Chandrasekhar Bal

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 7/2013

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Abstract

Purpose

Differentiation between recurrence and radiation necrosis in patients with glioma is crucial, since the two entities have completely different management and prognosis. The purpose of the present study was to compare the efficacies of ¹⁸F-FDG PET/CT and 3,4-dihydroxy-6-[¹⁸F]fluoro-phenylalanine (¹⁸F-FDOPA) PET/CT in detection of recurrent gliomas.

Methods

A total of 28 patients (age 38.82 ± 1.25 years; 85.7 % men) with histopathologically proven glioma with clinical/imaging suspicion of recurrence were evaluated using ¹⁸F-FDG PET/CT and ¹⁸F-FDOPA PET/CT. ¹⁸F-FDG PET/CT and ¹⁸F-FDOPA PET/CT images were evaluated qualitatively and semiquantitatively. The combination of clinical follow-up, repeat imaging and/or biopsy (when available) was taken as the reference standard.

Results

Based on the reference standard, 21 patients were positive and 7 were negative for tumour recurrence. The sensitivity, specificity and accuracy of ¹⁸F-FDG PET/CT were 47.6 %, 100 % and 60.7 %, respectively, and those of ¹⁸F-FDOPA PET/CT were 100 %, 85.7 % and 96.4 %, respectively. The results of ¹⁸F-FDG PET/CT and ¹⁸F-FDOPA PET/CT were concordant in 57.1 % of patients (16 of 28) and discordant in 42.9 % (12 of 28). The difference in the findings between ¹⁸F-FDG PET/CT and ¹⁸F-FDOPA PET/CT was significant (P = 0.0005, McNemar’s test). The difference was significant for low-grade tumours (P = 0.0039) but not for high-grade tumours (P = 0.250).

Conclusion

¹⁸F-FDOPA PET/CT is highly sensitive and specific for detection of recurrence in glioma patients. It is superior to ¹⁸F-FDG PET/CT for this purpose and is especially advantageous in patients with low-grade gliomas.

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Titel: 18F-FDOPA PET/CT for detection of recurrence in patients with glioma: prospective comparison with 18F-FDG PET/CT
verfasst von: Sellam Karunanithi
Punit Sharma
Abhishek Kumar
Bangkim Chandra Khangembam
Guru Pada Bandopadhyaya
Rakesh Kumar
Deepak Kumar Gupta
Arun Malhotra
Chandrasekhar Bal
Publikationsdatum: 01.07.2013
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 7/2013
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2384-0

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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