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European Journal of Nuclear Medicine and Molecular Imaging

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01.08.2013 | Short Communication

¹⁸F-FDG PET/CT diagnosis of unexpected extracardiac septic embolisms in patients with suspected cardiac endocarditis

verfasst von: Rachele Bonfiglioli, Cristina Nanni, Joshua James Morigi, Maddalena Graziosi, Filippo Trapani, Michele Bartoletti, Fabio Tumietto, Valentina Ambrosini, Alice Ferretti, Domenico Rubello, Claudio Rapezzi, Pier Luigi Viale, Stefano Fanti

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 8/2013

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Abstract

Purpose

Acute infective endocarditis is a potentially life-threatening disease. Its outcome strongly depends on systemic embolization and extracardiac infections. When present, these conditions usually lead to a more aggressive therapeutic approach. However, the diagnosis of peripheral septic embolism is very challenging. ¹⁸F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT has proven to be accurate for the detection of inflammatory diseases and occult infections. The aim of this study was to assess the added value of ¹⁸F-FDG PET/CT in the detection of extracardiac embolisms in the evaluation of patients with suspected valvular endocarditis (VE).

Methods

Seventy-one patients with suspected infective endocarditis, enrolled between June 2010 and December 2012, underwent ¹⁸F-FDG PET/CT with the standard procedure on a dedicated PET/CT scanner. Extracardiac findings were subsequently evaluated with other imaging procedures.

Results

Of the 71 patients with suspicion of infective endocarditis, we found unexpected extracardiac findings in 17 patients (24 %) without any clinical suspicion. Extracardiac findings were subsequently evaluated with other imaging procedures.

Conclusion

PET/CT detected unexpected extra sites of infection in 24 % of cases, leading to changes in therapeutic management in a very relevant percentage of patients. These findings may have important therapeutic implications.

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Titel: 18F-FDG PET/CT diagnosis of unexpected extracardiac septic embolisms in patients with suspected cardiac endocarditis
verfasst von: Rachele Bonfiglioli
Cristina Nanni
Joshua James Morigi
Maddalena Graziosi
Filippo Trapani
Michele Bartoletti
Fabio Tumietto
Valentina Ambrosini
Alice Ferretti
Domenico Rubello
Claudio Rapezzi
Pier Luigi Viale
Stefano Fanti
Publikationsdatum: 01.08.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 8/2013
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2426-7

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

¹⁸F-FDG PET/CT diagnosis of unexpected extracardiac septic embolisms in patients with suspected cardiac endocarditis

Abstract

Purpose

Methods

Results

Conclusion

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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