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Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 4/2014

01.04.2014 | Original Article

Image acquisition and interpretation criteria for 99mTc-HMPAO-labelled white blood cell scintigraphy: results of a multicentre study

verfasst von: Paola A. Erba, Andor W. J. M. Glaudemans, Niels C. Veltman, Martina Sollini, Marta Pacilio, Filippo Galli, Rudi A. J. O. Dierckx, Alberto Signore

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 4/2014

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Abstract

Purpose

There is no consensus yet on the best protocol for planar image acquisition and interpretation of radiolabelled white blood cell (WBC) scintigraphy. This may account for differences in reported diagnostic accuracy amongst different centres.

Methods

This was a multicentre retrospective study analysing 235 WBC scans divided into two groups. The first group of scans (105 patients) were acquired with a fixed-time acquisition protocol and the second group (130 patients) were acquired with a decay time-corrected acquisition protocol. Planar images were interpreted both qualitatively and semiquantitatively. Three blinded readers analysed the images.

Results

The most accurate imaging acquisition protocol comprised image acquisition at 3 – 4 h and at 20 – 24 h in time mode with acquisition times corrected for isotope decay.

Conclusion

Using this protocol, visual analysis had high sensitivity and specificity in the diagnosis of infection. Semiquantitative analysis could be used in doubtful cases, with no cut-off for the percentage increase in radiolabelled WBC over time, as a criterion to define a positive scan.
Literatur
1.
Zurück zum Zitat Van der Bruggen W, Bleeker-Rovers CP, Boerman OC, Gotthardt M, Oyen WJ. PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review. Semin Nucl Med. 2010;40:3–15.PubMedCrossRef Van der Bruggen W, Bleeker-Rovers CP, Boerman OC, Gotthardt M, Oyen WJ. PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review. Semin Nucl Med. 2010;40:3–15.PubMedCrossRef
2.
Zurück zum Zitat Signore A, Glaudemans AW. The molecular imaging approach to image infections and inflammation by nuclear medicine techniques. Ann Nucl Med. 2011;25:681–700.PubMedCrossRef Signore A, Glaudemans AW. The molecular imaging approach to image infections and inflammation by nuclear medicine techniques. Ann Nucl Med. 2011;25:681–700.PubMedCrossRef
3.
Zurück zum Zitat Palestro CJ, Love C, Bhargava KK. Labeled leukocyte imaging: current status and future directions. Q J Nucl Med Mol Imaging. 2009;53:105–23.PubMed Palestro CJ, Love C, Bhargava KK. Labeled leukocyte imaging: current status and future directions. Q J Nucl Med Mol Imaging. 2009;53:105–23.PubMed
4.
Zurück zum Zitat Love C, Marwin SE, Palestro CJ. Nuclear medicine and the infected joint replacement. Semin Nucl Med. 2009;39:66–78.PubMedCrossRef Love C, Marwin SE, Palestro CJ. Nuclear medicine and the infected joint replacement. Semin Nucl Med. 2009;39:66–78.PubMedCrossRef
5.
Zurück zum Zitat Gemmel F, Van den Wyngaert H, Love C, Welling MM, Gemmel P, Palestro CJ. Prosthetic joint infections: radionuclide state-of-the-art imaging. Eur J Nucl Med Mol Imaging. 2012;39:892–909.PubMedCrossRef Gemmel F, Van den Wyngaert H, Love C, Welling MM, Gemmel P, Palestro CJ. Prosthetic joint infections: radionuclide state-of-the-art imaging. Eur J Nucl Med Mol Imaging. 2012;39:892–909.PubMedCrossRef
6.
Zurück zum Zitat Tondeur MC, Sand A, Ham HH. Interobserver reproducibility in the interpretation of 99mTc-labelled white blood cell scintigraphic images. Nucl Med Commun. 2008;29:1093–9.PubMedCrossRef Tondeur MC, Sand A, Ham HH. Interobserver reproducibility in the interpretation of 99mTc-labelled white blood cell scintigraphic images. Nucl Med Commun. 2008;29:1093–9.PubMedCrossRef
7.
Zurück zum Zitat Glaudemans AW, Galli F, Pacilio M, Signore A. Leukocyte and bacteria imaging in prosthetic joint infections. Eur Cell Mater. 2013;25:61–77.PubMed Glaudemans AW, Galli F, Pacilio M, Signore A. Leukocyte and bacteria imaging in prosthetic joint infections. Eur Cell Mater. 2013;25:61–77.PubMed
8.
Zurück zum Zitat De Vries EF, Roca M, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37:842–8.PubMedCentralPubMedCrossRef De Vries EF, Roca M, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37:842–8.PubMedCentralPubMedCrossRef
9.
Zurück zum Zitat Roca M, De Vries EF, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with (111)In-oxine. Inflammation/infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37:835–41.PubMedCentralPubMedCrossRef Roca M, De Vries EF, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with (111)In-oxine. Inflammation/infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37:835–41.PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat Gotthardt M, Bleeker-Rovers CP, Boerman OC, Oyen WJ. Imaging of inflammation by PET, conventional scintigraphy, and other imaging techniques. J Nucl Med. 2010;51:1937–49.PubMed Gotthardt M, Bleeker-Rovers CP, Boerman OC, Oyen WJ. Imaging of inflammation by PET, conventional scintigraphy, and other imaging techniques. J Nucl Med. 2010;51:1937–49.PubMed
11.
Zurück zum Zitat Erba PA, Conti U, Lazzeri E, Sollini M, Doria R, De Tommasi SM, et al. Added value of 99mTc-HMPAO labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis. J Nucl Med. 2012;53:1235–43.PubMedCrossRef Erba PA, Conti U, Lazzeri E, Sollini M, Doria R, De Tommasi SM, et al. Added value of 99mTc-HMPAO labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis. J Nucl Med. 2012;53:1235–43.PubMedCrossRef
12.
Zurück zum Zitat Glaudemans AWJM, de Vries EFJ, Vermeulen LEM, Slart RHJA, Dierckx RAJO, Signore A. A large retrospective single-centre study to define the best image acquisition protocols and interpretation criteria for white blood cell scintigraphy with 99mTc-HMPAO-labelled leukocytes in musculoskeletal infections. Eur J Nucl Med Mol Imaging. 2013;40:1760–9.PubMedCrossRef Glaudemans AWJM, de Vries EFJ, Vermeulen LEM, Slart RHJA, Dierckx RAJO, Signore A. A large retrospective single-centre study to define the best image acquisition protocols and interpretation criteria for white blood cell scintigraphy with 99mTc-HMPAO-labelled leukocytes in musculoskeletal infections. Eur J Nucl Med Mol Imaging. 2013;40:1760–9.PubMedCrossRef
13.
Zurück zum Zitat Raoult D, Casalta JP, Richet H, et al. Contribution of systematic serological testing in diagnosis of infective endocarditis. J Clin Microbiol. 2005;43:5238–42.PubMedCentralPubMedCrossRef Raoult D, Casalta JP, Richet H, et al. Contribution of systematic serological testing in diagnosis of infective endocarditis. J Clin Microbiol. 2005;43:5238–42.PubMedCentralPubMedCrossRef
14.
Zurück zum Zitat Familiari D, Glaudemans AW, Vitale V, Prosperi D, Bagni O, Lenza A, et al. Can sequential 18F-FDG PET/CT replace WBC imaging in the diabetic foot? J Nucl Med. 2011;52:1012–9.PubMedCrossRef Familiari D, Glaudemans AW, Vitale V, Prosperi D, Bagni O, Lenza A, et al. Can sequential 18F-FDG PET/CT replace WBC imaging in the diabetic foot? J Nucl Med. 2011;52:1012–9.PubMedCrossRef
15.
Zurück zum Zitat Grippaudo FR, Pacilio M, Di Girolamo M, Dierckx RA, Signore A. Radiolabelled white blood cells in the work out of dermal filler complications. Eur J Nucl Med Mol Imaging. 2013;40:418–25.PubMedCrossRef Grippaudo FR, Pacilio M, Di Girolamo M, Dierckx RA, Signore A. Radiolabelled white blood cells in the work out of dermal filler complications. Eur J Nucl Med Mol Imaging. 2013;40:418–25.PubMedCrossRef
16.
Zurück zum Zitat Signore A. Techniques, image acquisition and interpretation criteria. In: Signore A, Quintero AM, editors. Diagnostic imaging of infections and inflammatory diseases: a multidisciplinary approach. New York: Wiley; 2013. p. 149–67.CrossRef Signore A. Techniques, image acquisition and interpretation criteria. In: Signore A, Quintero AM, editors. Diagnostic imaging of infections and inflammatory diseases: a multidisciplinary approach. New York: Wiley; 2013. p. 149–67.CrossRef
17.
Zurück zum Zitat Glaudemans AW, De Vries EF, Vermeulen LE, Slart RH, Dierckx RA, Signore A. A large retrospective single-centre study to define the best image acquisition protocols and interpretation criteria for white blood cell scintigraphy with 99mTc-HMPAO-labelled leucocytes in musculoskeletal infections. Eur J Nucl Med Mol Imaging. 2013;40:1760–9.PubMedCrossRef Glaudemans AW, De Vries EF, Vermeulen LE, Slart RH, Dierckx RA, Signore A. A large retrospective single-centre study to define the best image acquisition protocols and interpretation criteria for white blood cell scintigraphy with 99mTc-HMPAO-labelled leucocytes in musculoskeletal infections. Eur J Nucl Med Mol Imaging. 2013;40:1760–9.PubMedCrossRef
18.
Zurück zum Zitat Schillaci O. Hybrid imaging systems in the diagnosis of osteomyelitis and prosthetic joint infection. Q J Nucl Med Mol Imaging. 2009;53:95–104.PubMed Schillaci O. Hybrid imaging systems in the diagnosis of osteomyelitis and prosthetic joint infection. Q J Nucl Med Mol Imaging. 2009;53:95–104.PubMed
Metadaten
Titel
Image acquisition and interpretation criteria for 99mTc-HMPAO-labelled white blood cell scintigraphy: results of a multicentre study
verfasst von
Paola A. Erba
Andor W. J. M. Glaudemans
Niels C. Veltman
Martina Sollini
Marta Pacilio
Filippo Galli
Rudi A. J. O. Dierckx
Alberto Signore
Publikationsdatum
01.04.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 4/2014
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-013-2631-4

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