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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.04.2015 | Original Article

Cortical activity during olfactory stimulation in multiple chemical sensitivity: a ¹⁸F-FDG PET/CT study

verfasst von: Agostino Chiaravalloti, Marco Pagani, Alessandro Micarelli, Barbara Di Pietro, Giuseppe Genovesi, Marco Alessandrini, Orazio Schillaci

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 5/2015

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Abstract

Purpose

To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals.

Methods

Two ¹⁸F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in ¹⁸F-FDG uptake were analysed by statistical parametric mapping (SPM2).

Results

In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10.

Conclusion

The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.

Dantoft TM, Elberling J, Brix S, Szecsi PB, Vesterhauge S, Skovbjerg S. An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity. Psychoneuroendocrinology. 2014;40:140–50.CrossRefPubMed

Alessandrini M, Micarelli A, Chiaravalloti A, Candidi M, Bruno E, Di Pietro B, et al. Cortico-subcortical metabolic correlates of olfactory processing in healthy resting subjects. Sci Rep. 2014;4:5146.CrossRefPubMedCentralPubMed

Karnekull SC, Jonsson FU, Larsson M, Olofsson JK. Affected by smells? Environmental chemical responsivity predicts odor perception. Chem Senses. 2011;36:641–8.CrossRefPubMed

Andersson L, Claeson AS, Nyberg L, Stenberg B, Nordin S. Brain responses to olfactory and trigeminal exposure in idiopathic environmental illness (IEI) attributed to smells – an fMRI study. J Psychosom Res. 2014;77:401–8.CrossRefPubMed

Orriols R, Costa R, Cuberas G, Jacas C, Castell J, Sunyer J. Brain dysfunction in multiple chemical sensitivity. J Neurol Sci. 2009;287:72–8.CrossRefPubMed

Hillert L, Musabasic V, Berglund H, Ciumas C, Savic I. Odor processing in multiple chemical sensitivity. Hum Brain Mapp. 2007;28:172–82.CrossRefPubMed

Alessandrini M, Micarelli A, Bruno E, Ottaviani F, Conetta M, Cormano A, et al. Intranasal administration of hyaluronan as a further resource in olfactory performance in multiple chemical sensitivity syndrome. Int J Immunopathol Pharmacol. 2013;26:1019–25.PubMed

Firestein S. How the olfactory system makes sense of scents. Nature. 2001;413:211–8.CrossRefPubMed

Price JL. The olfactory system. In: Paxinos G, editor. The human nervous system. San Diego: Academic; 2003. p. 1198–212.

10.

Carmichael ST, Clugnet MC, Price JL. Central olfactory connections in the macaque monkey. J Comp Neurol. 1994;346:403–34.CrossRefPubMed

11.

Price JL. Beyond the primary olfactory cortex: olfactory-related areas in the neocortex, thalamus and hypothalamus. Chem Senses. 1985;10:239–58. doi:10.1093/chemse/10.2.239.CrossRef

12.

Rolls ET, Critchley HD, Treves A. Representation of olfactory information in the primate orbitofrontal cortex. J Neurophysiol. 1996;75:1982–96.

13.

Lundstrom JN, Boyle JA, Zatorre RJ, Jones-Gotman M. The neuronal substrates of human olfactory based kin recognition. Hum Brain Mapp. 2009;30:2571–80.CrossRefPubMed

14.

Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E. Functional localization and lateralization of human olfactory cortex. Nature. 1992;360:339–40.CrossRefPubMed

15.

Kobal G, Hummel T, Sekinger B, Barz S, Roscher S, Wolf S. “Sniffin’ sticks”: screening of olfactory performance. Rhinology. 1996;34:222–6.PubMed

16.

Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med. 1987;2:655–61.PubMed

17.

Laffon E, Bardies M, Barbet J, Marthan R. Kinetic model analysis for absorbed dose calculation applied to brain in [18F]-fluorodeoxyglucose positron emission tomography imaging. Cancer Biother Radiopharm. 2010;25:665–9.CrossRefPubMed

18.

Schmidt K, Mies G, Sokoloff L. Model of kinetic behavior of deoxyglucose in heterogeneous tissues in brain: a reinterpretation of the significance of parameters fitted to homogeneous tissue models. J Cereb Blood Flow Metab. 1991;11:10–24.CrossRefPubMed

19.

Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977;28:897–916.CrossRefPubMed

20.

Savic I. Brain imaging studies of the functional organization of human olfaction. Neuroscientist. 2002;8:204–11.CrossRefPubMed

21.

Alessandrini M, Pagani M, Napolitano B, Micarelli A, Candidi M, Bruno E, et al. Early and phasic cortical metabolic changes in vestibular neuritis onset. PLoS One. 2013;8:e57596.CrossRefPubMedCentralPubMed

22.

Bennett CM, Wolford GL, Miller MB. The principled control of false positives in neuroimaging. Soc Cogn Affect Neurosci. 2009;4:417–22.CrossRefPubMedCentralPubMed

23.

Kinomura S, Kawashima R, Yamada K, Ono S, Itoh M, Yoshioka S, et al. Functional anatomy of taste perception in the human brain studied with positron emission tomography. Brain Res. 1994;659:263–6.CrossRefPubMed

24.

Wang J, Eslinger PJ, Smith MB, Yang QX. Functional magnetic resonance imaging study of human olfaction and normal aging. J Gerontol A Biol Sci Med Sci. 2005;60:510–4.CrossRefPubMed

25.

Arshamian A, Iannilli E, Gerber JC, Willander J, Persson J, Seo HS, et al. The functional neuroanatomy of odor evoked autobiographical memories cued by odors and words. Neuropsychologia. 2013;51:123–31.CrossRefPubMed

26.

Royet JP, Zald D, Versace R, Costes N, Lavenne F, Koenig O, et al. Emotional responses to pleasant and unpleasant olfactory, visual, and auditory stimuli: a positron emission tomography study. J Neurosci. 2000;20:7752–9.PubMed

27.

Rolls ET, Grabenhorst F, Margot C, da Silva MA, Velazco MI. Selective attention to affective value alters how the brain processes olfactory stimuli. J Cogn Neurosci. 2008;20:1815–26.CrossRefPubMed

28.

Rolls ET, Kringelbach ML, de Araujo IE. Different representations of pleasant and unpleasant odours in the human brain. Eur J Neurosci. 2003;18:695–703.CrossRefPubMed

29.

Gottfried JA, Zald DH. On the scent of human olfactory orbitofrontal cortex: meta-analysis and comparison to non-human primates. Brain Res Brain Res Rev. 2005;50:287–304.CrossRefPubMed

30.

Boyle JA, Djordjevic J, Olsson MJ, Lundstrom JN, Jones-Gotman M. The human brain distinguishes between single odorants and binary mixtures. Cereb Cortex. 2009;19:66–71.CrossRefPubMed

31.

Catani M, Jones DK, Donato R, Ffytche DH. Occipito-temporal connections in the human brain. Brain. 2003;126:2093–107.CrossRefPubMed

32.

Chan D, Fox NC, Scahill RI, Crum WR, Whitwell JL, Leschziner G, et al. Patterns of temporal lobe atrophy in semantic dementia and Alzheimer’s disease. Ann Neurol. 2001;49:433–42.CrossRefPubMed

33.

Azuma K, Uchiyama I, Takano H, Tanigawa M, Azuma M, Bamba I, et al. Changes in cerebral blood flow during olfactory stimulation in patients with multiple chemical sensitivity: a multi-channel near-infrared spectroscopic study. PLoS One. 2013;8:e80567.CrossRefPubMedCentralPubMed

34.

Ahs F, Miller SS, Gordon AR, Lundstrom JN. Aversive learning increases sensory detection sensitivity. Biol Psychol. 2013;92:135–41.CrossRefPubMed

35.

Berg ND, Linneberg A, Dirksen A, Elberling J. Prevalence of self-reported symptoms and consequences related to inhalation of airborne chemicals in a Danish general population. Int Arch Occup Environ Health. 2008;81:881–7.CrossRefPubMed

36.

Siddiqui SV, Chatterjee U, Kumar D, Siddiqui A, Goyal N. Neuropsychology of prefrontal cortex. Indian J Psychiatr. 2008;50:202–8.CrossRef

37.

Bornschein S, Hausteiner C, Zilker T, Forstl H. Psychiatric and somatic disorders and multiple chemical sensitivity (MCS) in 264 ‘environmental patients’. Psychol Med. 2002;32:1387–94.CrossRefPubMed

Titel: Cortical activity during olfactory stimulation in multiple chemical sensitivity: a 18F-FDG PET/CT study
verfasst von: Agostino Chiaravalloti
Marco Pagani
Alessandro Micarelli
Barbara Di Pietro
Giuseppe Genovesi
Marco Alessandrini
Orazio Schillaci
Publikationsdatum: 01.04.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 5/2015
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-014-2969-2

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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