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Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 1/2016

01.01.2016 | Original Article

Locoregional tumour evaluation of squamous cell carcinoma in the head and neck area: a comparison between MRI, PET/CT and integrated PET/MRI

verfasst von: Benedikt Michael Schaarschmidt, Philipp Heusch, Christian Buchbender, Marcus Ruhlmann, Christoph Bergmann, Verena Ruhlmann, Marc Schlamann, Gerald Antoch, Michael Forsting, Axel Wetter

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 1/2016

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Abstract

Purpose

To evaluate the accuracy of integrated 18F-FDG PET/MR imaging for locoregional tumour evaluation compared to 18F-FDG PET/CT and MR imaging in initial tumour and recurrence diagnosis in histopathologically confirmed head and neck squamous cell carcinoma (HNSCC).

Methods

18F-FDG PET/CT and integrated 18F-FDG PET/MR imaging were performed for initial tumour staging or recurrence diagnosis in 25 patients with HNSCC. MR, fused 18F-FDG PET/CT and fused 18F-FDG PET/MR images were analysed by two independent readers in separate sessions in random order. In initial tumour staging, T and N staging was performed while individual lesions were analysed in patients with suspected cancer recurrence. In T and N staging, histopathological results after tumour resection served as the reference standard while histopathological sampling as well as cross-sectional and clinical follow-up were accepted in cancer recurrence diagnosis. The diagnostic accuracy of each modality was calculated separately for T and N staging as well as for tumour recurrence, and compared using McNemar’s test. Values of p <0.017 were considered statistically significant after Bonferroni correction.

Results

In 12 patients undergoing 18F-FDG PET/CT and 18F-FDG PET/MR for initial tumour staging, T staging was accurate in 50 % with MRI, in 59 % with PET/CT and in 75 % with PET/MR while N staging was accurate in 75 % with MRI, in 77 % with PET/CT and in 71 % with PET/MR in relation to the reference standard. No significant differences were observed in T and N staging among the three modalities (p > 0.017). In 13 patients undergoing hybrid imaging for cancer recurrence diagnosis, diagnostic accuracy was 57 % with MRI and in 72 % with 18F-FDG PET/CT and 18F-FDG PET/MR, respectively. Again, no significant differences were found among the three modalities (p > 0.017).

Conclusion

In this initial study, no significant differences were found among 18F-FDG PET/MR, 18F-FDG PET/CT and MRI in local tumour staging and cancer recurrence diagnosis.
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Metadaten
Titel
Locoregional tumour evaluation of squamous cell carcinoma in the head and neck area: a comparison between MRI, PET/CT and integrated PET/MRI
verfasst von
Benedikt Michael Schaarschmidt
Philipp Heusch
Christian Buchbender
Marcus Ruhlmann
Christoph Bergmann
Verena Ruhlmann
Marc Schlamann
Gerald Antoch
Michael Forsting
Axel Wetter
Publikationsdatum
01.01.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 1/2016
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-015-3145-z

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