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Staging of uterine cervical carcinoma: whole-body diffusion-weighted magnetic resonance imaging

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Abstract

Purpose

To evaluate the clinical value of magnetic resonance whole-body diffusion-weighted imaging (WB-DWI) in the staging of uterine cervical carcinoma.

Materials and methods

Twenty-six patients with untreated uterine cervical carcinoma received preoperative conventional MR and WB-DWI scans. WB-DWI scans were also obtained in 30 healthy volunteers. Measurements of apparent diffusion coefficient (ADC) were made on scans of normal uterine cervix and uterine cervical carcinoma, and benign and metastatic lymph nodes. Statistical analysis was applied to the obtained data.

Results

Mean ADC value of uterine cervical carcinoma was significantly lower than the 3 layers of normal uterine cervix (P = 0.00). When an ADC value of 1.28 × 10−3 mm2/s is used as the threshold, its sensitivity is 96%, specificity is 100%, and accuracy is 98%. Mean ADC value of metastatic nodes [(0.96 ± 0.14) × 10−3 mm2/s] was significantly lower than that of benign nodes [(1.39 ± 0.19) × 10−3 mm2/s] (t = 9.93, P = 0.00). When an ADC value of 1.14 × 10−3 mm2/s is used as the threshold, its sensitivity is 83%, specificity is 98%, and accuracy is 94%.

Conclusion

WB-DWI scan is capable of distinguishing uterine cervical carcinoma from normal uterine cervix, and is capable of separating metastatic nodes from benign nodes.

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Authors and Affiliations

  1. Department of Radiology, Fujian Medical University Teaching Hospital, Fujian Provincial Cancer Hospital & Institute, Fuzhou, Fujian, China

    Yun B. Chen, Chun M. Hu & Jiang Liao

  2. Department of Gynecological Oncology, Fujian Medical University Teaching Hospital, Fujian Provincial Cancer Hospital & Institute, Fuzhou, Fujian, China

    Gui L. Chen

  3. Department of Pathology, Fujian Medical University Teaching Hospital, Fujian Provincial Cancer Hospital & Institute, Fuzhou, Fujian, China

    Dan Hu

Authors
  1. Yun B. Chen
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  2. Chun M. Hu
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  3. Gui L. Chen
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  4. Dan Hu
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  5. Jiang Liao
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Correspondence to Yun B. Chen.

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Chen, Y.B., Hu, C.M., Chen, G.L. et al. Staging of uterine cervical carcinoma: whole-body diffusion-weighted magnetic resonance imaging. Abdom Imaging 36, 619–626 (2011). https://doi.org/10.1007/s00261-010-9642-4

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