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Erschienen in: Abdominal Radiology 7/2016

08.03.2016

Dual-energy CT of pancreatic adenocarcinoma: reproducibility of primary tumor measurements and assessment of tumor conspicuity and margin sharpness

verfasst von: Shiva Gupta, Nicolaus Wagner-Bartak, Corey T. Jensen, Anthony Hui, Wei Wei, Patrick Lertdilok, Aliya Qayyum, Eric P. Tamm

Erschienen in: Abdominal Radiology | Ausgabe 7/2016

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Abstract

Purpose

To determine the inter- and intra-reader agreement of size, conspicuity, and margin sharpness of pancreatic adenocarcinoma on monochromatic, polychromatic, and iodine map dual-energy CT (DECT) images.

Methods

Retrospective review of DECT images from 61 patients with untreated pancreatic adenocarcinoma was performed by three radiologists independently. Pancreatic parenchymal phase images were generated as 50 and 70 keV, 140 kVp quality control (QC), and iodine map images. These were analyzed in a blinded randomized order during four reading sessions separated by 5–7 days. For each image set, readers recorded the longest axial and perpendicular primary tumor dimensions, and qualitatively scored tumor conspicuity and edge sharpness on 5-point scales. Linear mixed model was used to estimate and compare tumor measurements, tumor conspicuity, and tumor edge sharpness scores between readers and image sets. Kappa statistics were used to determine inter-observer agreement for tumor conspicuity and edge sharpness.

Results

The range of tumor measures (mean of longest dimension ± standard deviation) was 3.18 ± 1.41 to 3.83 ± 1.57 cm. Reproducibility of tumor measurements was very high with mild variability (s 2 = 0.01–0.10) between readers for the different image sets. Inter-observer agreement values for tumor conspicuity (κ = 0.01–0.17) and edge sharpness (κ = 0.12–0.25) were low for all image sets, although two of three readers scored tumor conspicuity and edge sharpness higher on monochromatic and iodine map DECT images than on 140 kVp QC images (p < 0.05).

Conclusions

Pancreatic adenocarcinoma measurements were highly reproducible on DECT images, and subjective reader preference trended toward monochromatic and iodine images rather than polychromatic images.
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Metadaten
Titel
Dual-energy CT of pancreatic adenocarcinoma: reproducibility of primary tumor measurements and assessment of tumor conspicuity and margin sharpness
verfasst von
Shiva Gupta
Nicolaus Wagner-Bartak
Corey T. Jensen
Anthony Hui
Wei Wei
Patrick Lertdilok
Aliya Qayyum
Eric P. Tamm
Publikationsdatum
08.03.2016
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 7/2016
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-016-0689-8

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