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Erschienen in: Abdominal Radiology 1/2018

24.06.2017

Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis

verfasst von: An Tang, Oussama Hallouch, Victoria Chernyak, Aya Kamaya, Claude B. Sirlin

Erschienen in: Abdominal Radiology | Ausgabe 1/2018

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Abstract

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer mortality worldwide. Incidence rates of liver cancer vary widely between geographic regions and are highest in Eastern Asia and sub-Saharan Africa. In the United States, the incidence of HCC has increased since the 1980s. HCC detection at an early stage through surveillance and curative therapy has considerably improved the 5-year survival. Therefore, medical societies advocate systematic screening and surveillance of target populations at particularly high risk for developing HCC to facilitate early-stage detection. Risk factors for HCC include cirrhosis, chronic infection with hepatitis B virus (HBV), hepatitis C virus (HCV), excess alcohol consumption, non-alcoholic fatty liver disease, family history of HCC, obesity, type 2 diabetes mellitus, and smoking. Medical societies utilize risk estimates to define target patient populations in which imaging surveillance is recommended (risk above threshold) or in which the benefits of surveillance are uncertain (risk unknown or below threshold). All medical societies currently recommend screening and surveillance in patients with cirrhosis and subsets of patients with chronic HBV; some societies also include patients with stage 3 fibrosis due to HCV as well as additional groups. Thus, target population definitions vary between regions, reflecting cultural, demographic, economic, healthcare priority, and biological differences. The Liver Imaging Reporting and Data System (LI-RADS) defines different patient populations for surveillance and for diagnosis and staging. We also discuss general trends pertaining to geographic region, age, gender, ethnicity, impact of surveillance on survival, mortality, and future trends.
Literatur
6.
Zurück zum Zitat Surveillance, Epidemiology, and End Results (SEER) Program. SEER*Stat database: incidence—SEER 9 Regs research data, Nov 2009 Sub (1973–2007). Bethesda, MD: National Cancer Institute, April 2010. Surveillance, Epidemiology, and End Results (SEER) Program. SEER*Stat database: incidence—SEER 9 Regs research data, Nov 2009 Sub (1973–2007). Bethesda, MD: National Cancer Institute, April 2010.
7.
Zurück zum Zitat Foundation CL (2013) Liver disease in Canada: A crisis in the making. Halifax: Foundation CL Foundation CL (2013) Liver disease in Canada: A crisis in the making. Halifax: Foundation CL
11.
Zurück zum Zitat European Association For The Study Of The L, European Organisation For R, Treatment Of C (2012) EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 56(4):908–943. doi:10.1016/j.jhep.2011.12.001 CrossRef European Association For The Study Of The L, European Organisation For R, Treatment Of C (2012) EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 56(4):908–943. doi:10.​1016/​j.​jhep.​2011.​12.​001 CrossRef
12.
Zurück zum Zitat Kudo M, Matsui O, Izumi N, et al. (2014) JSH consensus-based clinical practice guidelines for the management of hepatocellular carcinoma: 2014 Update by the Liver Cancer Study Group of Japan. Liver Cancer 3(3–4):458–468. doi:10.1159/000343875 CrossRefPubMedPubMedCentral Kudo M, Matsui O, Izumi N, et al. (2014) JSH consensus-based clinical practice guidelines for the management of hepatocellular carcinoma: 2014 Update by the Liver Cancer Study Group of Japan. Liver Cancer 3(3–4):458–468. doi:10.​1159/​000343875 CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Kudo M, Izumi N, Kokudo N, et al. (2011) Management of hepatocellular carcinoma in Japan: Consensus-based clinical practice guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version. Dig Dis 29(3):339–364. doi:10.1159/000327577 CrossRefPubMed Kudo M, Izumi N, Kokudo N, et al. (2011) Management of hepatocellular carcinoma in Japan: Consensus-based clinical practice guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version. Dig Dis 29(3):339–364. doi:10.​1159/​000327577 CrossRefPubMed
15.
Zurück zum Zitat Korean Liver Cancer Study G, National Cancer Center K (2015) 2014 Korean Liver Cancer Study Group-National Cancer Center Korea practice guideline for the management of hepatocellular carcinoma. Korean J Radiol: Off J Korean Radiol Soc 16(3):465–522. doi:10.3348/kjr.2015.16.3.465 CrossRef Korean Liver Cancer Study G, National Cancer Center K (2015) 2014 Korean Liver Cancer Study Group-National Cancer Center Korea practice guideline for the management of hepatocellular carcinoma. Korean J Radiol: Off J Korean Radiol Soc 16(3):465–522. doi:10.​3348/​kjr.​2015.​16.​3.​465 CrossRef
17.
Zurück zum Zitat An Tang, Kathryn J. Fowler, Victoria Chernyak, William C. Chapman, Claude B. Sirlin (2017) LI-RADS and transplantation for hepatocellular carcinoma. Abdom Radiol. doi:10.1007/s00261-017-1210-8 An Tang, Kathryn J. Fowler, Victoria Chernyak, William C. Chapman, Claude B. Sirlin (2017) LI-RADS and transplantation for hepatocellular carcinoma. Abdom Radiol. doi:10.​1007/​s00261-017-1210-8
21.
Zurück zum Zitat Fattovich G, Stroffolini T, Zagni I, Donato F (2004) Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 127(5 Suppl 1):S35–S50CrossRefPubMed Fattovich G, Stroffolini T, Zagni I, Donato F (2004) Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 127(5 Suppl 1):S35–S50CrossRefPubMed
22.
Zurück zum Zitat Theise ND (1996) Cirrhosis and hepatocellular neoplasia: more like cousins than like parent and child. Gastroenterology 111(2):526–528CrossRefPubMed Theise ND (1996) Cirrhosis and hepatocellular neoplasia: more like cousins than like parent and child. Gastroenterology 111(2):526–528CrossRefPubMed
28.
Zurück zum Zitat Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ (2015) Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet 386(10003):1546–1555. doi:10.1016/S0140-6736(15)61412-X CrossRefPubMed Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ (2015) Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet 386(10003):1546–1555. doi:10.​1016/​S0140-6736(15)61412-X CrossRefPubMed
37.
Zurück zum Zitat Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW (2010) Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 138 (2):513–521, 521 e511–516. doi:10.1053/j.gastro.2009.09.067 Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW (2010) Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 138 (2):513–521, 521 e511–516. doi:10.​1053/​j.​gastro.​2009.​09.​067
39.
Zurück zum Zitat Donato F, Tagger A, Gelatti U, et al. (2002) Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women. Am J Epidemiol 155(4):323–331CrossRefPubMed Donato F, Tagger A, Gelatti U, et al. (2002) Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women. Am J Epidemiol 155(4):323–331CrossRefPubMed
41.
Zurück zum Zitat La Vecchia C, Negri E, Cavalieri d’Oro L, Franceschi S (1998) Liver cirrhosis and the risk of primary liver cancer. Eur J Cancer Prev 7(4):315–320CrossRefPubMed La Vecchia C, Negri E, Cavalieri d’Oro L, Franceschi S (1998) Liver cirrhosis and the risk of primary liver cancer. Eur J Cancer Prev 7(4):315–320CrossRefPubMed
42.
Zurück zum Zitat Yuan JM, Govindarajan S, Arakawa K, Yu MC (2004) Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Cancer 101(5):1009–1017. doi:10.1002/cncr.20427 CrossRefPubMed Yuan JM, Govindarajan S, Arakawa K, Yu MC (2004) Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Cancer 101(5):1009–1017. doi:10.​1002/​cncr.​20427 CrossRefPubMed
43.
Zurück zum Zitat Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M (2015) Global epidemiology of non-alcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence and outcomes. Hepatology. doi:10.1002/hep.28431 Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M (2015) Global epidemiology of non-alcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence and outcomes. Hepatology. doi:10.​1002/​hep.​28431
46.
Zurück zum Zitat Mittal S, El-Serag HB, Sada YH, Kanwal F, Duan Z, Temple S, May SB, Kramer JR, Richardson PA, Davila JA (2016) Hepatocellular carcinoma in the absence of cirrhosis in United States veterans is Associated with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 14(1):124–131 e121. doi:10.1016/j.cgh.2015.07.019 Mittal S, El-Serag HB, Sada YH, Kanwal F, Duan Z, Temple S, May SB, Kramer JR, Richardson PA, Davila JA (2016) Hepatocellular carcinoma in the absence of cirrhosis in United States veterans is Associated with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 14(1):124–131 e121. doi:10.​1016/​j.​cgh.​2015.​07.​019
49.
Zurück zum Zitat Qian GS, Ross RK, Yu MC, et al. (1994) A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epidemiol Biomarkers Prev 3(1):3–10PubMed Qian GS, Ross RK, Yu MC, et al. (1994) A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epidemiol Biomarkers Prev 3(1):3–10PubMed
50.
Zurück zum Zitat Ross RK, Yuan JM, Yu MC, et al. (1992) Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 339(8799):943–946CrossRefPubMed Ross RK, Yuan JM, Yu MC, et al. (1992) Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 339(8799):943–946CrossRefPubMed
51.
Zurück zum Zitat Fan JH, Wang JB, Jiang Y, et al. (2013) Attributable causes of liver cancer mortality and incidence in china. Asian Pac J Cancer Prev 14(12):7251–7256CrossRefPubMed Fan JH, Wang JB, Jiang Y, et al. (2013) Attributable causes of liver cancer mortality and incidence in china. Asian Pac J Cancer Prev 14(12):7251–7256CrossRefPubMed
53.
Zurück zum Zitat Elmberg M, Hultcrantz R, Ekbom A, et al. (2003) Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives. Gastroenterology 125(6):1733–1741CrossRefPubMed Elmberg M, Hultcrantz R, Ekbom A, et al. (2003) Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives. Gastroenterology 125(6):1733–1741CrossRefPubMed
55.
Zurück zum Zitat Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348(17):1625–1638. doi:10.1056/NEJMoa021423 CrossRefPubMed Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348(17):1625–1638. doi:10.​1056/​NEJMoa021423 CrossRefPubMed
56.
Zurück zum Zitat Weng CJ, Hsieh YH, Tsai CM, et al. (2010) Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma. Ann Surg Oncol 17(7):1808–1815. doi:10.1245/s10434-009-0904-8 CrossRefPubMed Weng CJ, Hsieh YH, Tsai CM, et al. (2010) Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma. Ann Surg Oncol 17(7):1808–1815. doi:10.​1245/​s10434-009-0904-8 CrossRefPubMed
58.
60.
Zurück zum Zitat Humans IWGotEoCRt (2004) Tobacco smoke and involuntary smoking. IARC Monogr Eval Carcinog Risks Hum 83:1–1438 Humans IWGotEoCRt (2004) Tobacco smoke and involuntary smoking. IARC Monogr Eval Carcinog Risks Hum 83:1–1438
61.
Zurück zum Zitat Bosch FX, Ribes J, Diaz M, Cleries R (2004) Primary liver cancer: worldwide incidence and trends. Gastroenterology 127(5 Suppl 1):S5–S16CrossRefPubMed Bosch FX, Ribes J, Diaz M, Cleries R (2004) Primary liver cancer: worldwide incidence and trends. Gastroenterology 127(5 Suppl 1):S5–S16CrossRefPubMed
62.
Zurück zum Zitat McGavock JM, Victor RG, Unger RH, Szczepaniak LS (2006) Adiposity of the heart, revisited. Ann Internal Med 144(7):517–524CrossRef McGavock JM, Victor RG, Unger RH, Szczepaniak LS (2006) Adiposity of the heart, revisited. Ann Internal Med 144(7):517–524CrossRef
68.
Zurück zum Zitat Myers RP, Krajden M, Bilodeau M, et al. (2014) Burden of disease and cost of chronic hepatitis C infection in Canada. Can J Gastroenterol Hepatol 28(5):243–250CrossRefPubMedPubMedCentral Myers RP, Krajden M, Bilodeau M, et al. (2014) Burden of disease and cost of chronic hepatitis C infection in Canada. Can J Gastroenterol Hepatol 28(5):243–250CrossRefPubMedPubMedCentral
71.
Zurück zum Zitat Beasley RP, Hwang LY, Lin CC, Chien CS (1981) Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 2(8256):1129–1133CrossRefPubMed Beasley RP, Hwang LY, Lin CC, Chien CS (1981) Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 2(8256):1129–1133CrossRefPubMed
72.
Zurück zum Zitat Sherman M, Peltekian KM, Lee C (1995) Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North American urban population. Hepatology 22(2):432–438PubMed Sherman M, Peltekian KM, Lee C (1995) Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North American urban population. Hepatology 22(2):432–438PubMed
74.
Metadaten
Titel
Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis
verfasst von
An Tang
Oussama Hallouch
Victoria Chernyak
Aya Kamaya
Claude B. Sirlin
Publikationsdatum
24.06.2017
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 1/2018
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-017-1209-1

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