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Abdominal Radiology
Erschienen in: Abdominal Radiology 1/2020

08.10.2019 | Hepatobiliary

A comparative study of monoexponential versus biexponential models of diffusion-weighted imaging in differentiating histologic grades of hepatitis B virus-related hepatocellular carcinoma

verfasst von: Qungang Shan, Sichi Kuang, Yao Zhang, Bingjun He, Jun Wu, Tianhui Zhang, Jin Wang

Erschienen in: Abdominal Radiology | Ausgabe 1/2020

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Abstract

Purpose

To compare the diagnostic value of apparent diffusion coefficient (ADC) and intravoxel incoherent motion metrics in discriminating histologic grades of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection.

Methods

117 chronic HBV patients with 120 pathologically confirmed HCCs after surgical resection or liver transplantation were enrolled in this retrospective study. Diffusion-weighted imaging was performed using eleven b values (0–1500 s/mm2) and two b values (0, 800 s/mm2) successively on a 3.0 T system. ADC0, 800, ADCtotal, diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were calculated. The parameters of three histologically differentiated subtypes were investigated using Kruskal–Wallis test, Spearman rank correlation, and receiver-operating characteristic analysis. Interobserver agreement was assessed using the intraclass correlation coefficient.

Results

There was excellent agreement for ADCtotal/D/f, good agreement for ADC0,800, and moderate agreement for D*. ADCtotal, ADC0, 800,D, and f were significantly different for well, moderately, and poorly differentiated HCCs (P < 0.001), and they were all inversely correlated with histologic grades: r = − 0.633, − 0.394, − 0.435, and − 0.358, respectively (P < 0.001). ADCtotal demonstrated higher performance than ADC0,800 in diagnosing both well and poorly differentiated HCCs (P < 0.001 and P = 0.04, respectively). ADCtotal showed higher performance than D and f in diagnosing well differentiated HCCs (P < 0.001) and similar performance in diagnosing poorly differentiated HCCs (P = 0.06 and 0.13, respectively).

Conclusions

ADCtotal showed better diagnostic performance than ADC0,800, D, and f to discriminate histologic grades of HCC.
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Metadaten
Titel
A comparative study of monoexponential versus biexponential models of diffusion-weighted imaging in differentiating histologic grades of hepatitis B virus-related hepatocellular carcinoma
verfasst von
Qungang Shan
Sichi Kuang
Yao Zhang
Bingjun He
Jun Wu
Tianhui Zhang
Jin Wang
Publikationsdatum
08.10.2019
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 1/2020
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-019-02253-3

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