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Erschienen in: Cancer Immunology, Immunotherapy 12/2005

01.12.2005 | Original Article

CD8 T cells expressing NK associated receptors are increased in melanoma patients and display an effector phenotype

verfasst von: Javier G. Casado, Rocío Soto, Olga DelaRosa, Esther Peralbo, Maria del Carmen Muñoz-Villanueva, Luis Rioja, José Peña, Rafael Solana, Raquel Tarazona

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 12/2005

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Abstract

CD8+ T cells can express NK-associated receptors (NKRs) that may regulate their cytolytic function. We have characterized the expression of several NKRs on peripheral blood CD8+ T cells from melanoma patients and compared them to age-matched healthy donors. The analysis performed includes HLA class I specific receptors (KIRs, LILRB1 and CD94/NKG2) and other NK receptors like CD57, CD56 and CD16. Melanoma patients showed a higher variability in the expression of NKRs on circulating CD8+ T cells than age-matched healthy donors. NKR expression on CD8+ T cells from melanoma patients showed a significant increase of KIR2DL2/L3/S2 (mAb gl183), CD244, CD57, CD56 and CD16. We have also found an increase of CD8+ CD28 CD27 T cells in melanoma patients. This subset represents terminally differentiated effector cells expressing CD244 and high levels of perforin. The expression of NKRs was also mainly restricted to this T cell subset. Altogether, circulating CD8+ T cells from melanoma patients display a distinct phenotype characterized by downregulation of costimulatory molecules and higher expression of NKRs. We suggest that the increased expression of NKRs on T cells may contribute to the final outcome of the immune response against melanoma both stimulating or inhibiting activation and differentiation to effector cells. Blocking inhibitory receptor function and enhancing activating receptors may represent new strategies with therapeutic potential against melanoma.
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Metadaten
Titel
CD8 T cells expressing NK associated receptors are increased in melanoma patients and display an effector phenotype
verfasst von
Javier G. Casado
Rocío Soto
Olga DelaRosa
Esther Peralbo
Maria del Carmen Muñoz-Villanueva
Luis Rioja
José Peña
Rafael Solana
Raquel Tarazona
Publikationsdatum
01.12.2005
Erschienen in
Cancer Immunology, Immunotherapy / Ausgabe 12/2005
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-005-0682-5

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