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Cancer Immunology, Immunotherapy

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01.02.2007 | Original Article

Immune selective pressure and HLA class I antigen defects in malignant lesions

verfasst von: Chien-Chung Chang, Soldano Ferrone

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 2/2007

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Abstract

The revived cancer immune surveillance theory has emphasized the active role the immune system plays in eliminating tumor cells and in facilitating the emergence of their immunoresistant variants. MHC class I molecule abnormalities represent, at least in part, the molecular phenotype of these escape variants, given the crucial role of MHC class I molecules in eliciting tumor antigen-specific T cell responses, the high frequency of HLA class I antigen abnormalities in malignant lesions and their association with a poor clinical course of the disease. Here, we present evidence for this possibility and review the potential mechanisms by which T cell selective pressure participates in the generation of tumor cells with MHC class I molecule defects. Furthermore, we discuss the strategies to counteract tumor cell immune evasion.

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Titel: Immune selective pressure and HLA class I antigen defects in malignant lesions
verfasst von: Chien-Chung Chang
Soldano Ferrone
Publikationsdatum: 01.02.2007
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 2/2007
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-006-0183-1

Neu im Fachgebiet Onkologie

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Springer Medizin

Immune selective pressure and HLA class I antigen defects in malignant lesions

Abstract

Neu im Fachgebiet Onkologie

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ICI-Therapie in der Schwangerschaft wird gut toleriert

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Springer Medizin

Abstract

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