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Cancer Immunology, Immunotherapy

Erschienen in:

01.05.2009 | Focussed Research Review

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008

verfasst von: Wolfgang Uckert, Ton N. M. Schumacher

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 5/2009

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Abstract

The genetic introduction of T cell receptor genes into T cells has been developed over the past decade as a strategy to induce defined antigen-specific T cell immunity. With the potential value of TCR gene therapy well-established in murine models and the feasibility of infusion of TCR-modified autologous T cells shown in a first phase I trial, the next key step will be to transform TCR gene transfer from an experimental technique into a robust clinical strategy. In this review, we discuss the different properties of the TCR transgene and transgene cassette that can strongly affect both the efficacy and the safety of TCR gene transfer.

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Titel: TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008
verfasst von: Wolfgang Uckert
Ton N. M. Schumacher
Publikationsdatum: 01.05.2009
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 5/2009
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-008-0649-4

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Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie