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Erschienen in: Cancer Immunology, Immunotherapy 11/2010

01.11.2010 | Original Article

Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer

verfasst von: Jingting Jiang, Yibei Zhu, Changping Wu, Yueping Shen, Wenxiang Wei, Lujun Chen, Xiao Zheng, Jing Sun, Binfeng Lu, Xueguang Zhang

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 11/2010

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Abstract

To establish the prognostic value of B7-H4 expression by tumor cells in gastric cancer patients, we evaluated the association of B7-H4 expression with clinicopathologic factors and overall survival of gastric cancer patients. A retrospective cohort study including 156 gastric cancer patients was performed in the present report. Immunohistochemical assay was used to evaluate the expression of B7-H4 in the surgical specimens of gastric cancer tissues. Multi-univariate COX model was then used to evaluate the association of B7-H4 expression with the patients’ survival and clinicopathological parameters. B7-H4 expression in the gastric cancer cells was observed in about 44.9% gastric cancer specimens. Univariate analysis demonstrated that there was no correlation between B7-H4 expression and sex, age, histological type, pathological grade or tumor size. In contrast, B7-H4 expression correlated positively with cancer invasiveness and lymph node metastasis. In addition, the median overall survival time of patients with lower B7-H4 expression was 13 months longer than that of patients with higher expression (χ2 = 12.38, P < 0.0001), and the median disease-free survival time of patients with lower B7-H4 expression was significantly longer than that of patients with higher expression (33 vs. 16 months, χ2 = 14.977, P < 0.0001). After adjustment for other confounding factors, the COX model analysis indicated that the death risk was significantly higher in patients with higher B7-H4 expression than those with lower expression (RR = 1.85, 95% CI = 1.15–2.96). The present study demonstrated that higher B7-H4 expression in cancer cells was associated with poor prognosis of gastric cancer patients. This is consistent with the idea that B7-H4 promotes cancer progression, likely via inhibition of anti-tumor immune responses.
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Metadaten
Titel
Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
verfasst von
Jingting Jiang
Yibei Zhu
Changping Wu
Yueping Shen
Wenxiang Wei
Lujun Chen
Xiao Zheng
Jing Sun
Binfeng Lu
Xueguang Zhang
Publikationsdatum
01.11.2010
Verlag
Springer-Verlag
Erschienen in
Cancer Immunology, Immunotherapy / Ausgabe 11/2010
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-010-0900-7

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