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Cancer Immunology, Immunotherapy

Erschienen in:

01.07.2012 | Review

Targeted immunotherapy of cancer with CAR T cells: achievements and challenges

verfasst von: Grazyna Lipowska-Bhalla, David E. Gilham, Robert E. Hawkins, Dominic G. Rothwell

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 7/2012

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Abstract

The adoptive transfer of chimeric antigen receptor (CAR)-expressing T cells is a relatively new but promising approach in the field of cancer immunotherapy. This therapeutic strategy is based on the genetic reprogramming of T cells with an artificial immune receptor that redirects them against targets on malignant cells and enables their destruction by exerting T cell effector functions. There has been an explosion of interest in the use of CAR T cells as an immunotherapy for cancer. In the pre-clinical setting, there has been a considerable focus upon optimizing the structural and signaling potency of the CAR while advances in bio-processing technology now mean that the clinical testing of these gene-modified T cells has become a reality. This review will summarize the concept of CAR-based immunotherapy and recent clinical trial activity and will further discuss some of the likely future challenges facing CAR-modified T cell therapies.

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Titel: Targeted immunotherapy of cancer with CAR T cells: achievements and challenges
verfasst von: Grazyna Lipowska-Bhalla
David E. Gilham
Robert E. Hawkins
Dominic G. Rothwell
Publikationsdatum: 01.07.2012
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 7/2012
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-012-1254-0

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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