Erschienen in:
01.04.2014 | Original Article
PD-1+ immune cell infiltration inversely correlates with survival of operable breast cancer patients
verfasst von:
Shenyou Sun, Xiaochun Fei, Yan Mao, Xiumin Wang, David H. Garfield, Ou Huang, Jinglong Wang, Fei Yuan, Long Sun, Qixiang Yu, Xiaolong Jin, Jianhua Wang, Kunwei Shen
Erschienen in:
Cancer Immunology, Immunotherapy
|
Ausgabe 4/2014
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Abstract
The programmed death-1 (PD-1) molecule is mainly expressed on functionally “exhausted” CD8+ T cells, dampening the host antitumor immune response. We evaluated the ratio between effective and regulatory T cells (Tregs) and PD-1 expression as a prognostic factor for operable breast cancer patients. A series of 218 newly diagnosed invasive breast cancer patients who had undergone primary surgery at Ruijin Hospital were identified. The influence of CD8+ cytotoxic T lymphocytes, FOXP3+ (Treg cell marker), and PD-1+ immune cell counts on prognosis was analyzed utilizing immunohistochemistry. Both PD-1+ immune cells and FOXP3+ Tregs counts were significantly associated with unfavorable prognostic factors. In bivariate, but not multivariate analysis, high tumor infiltrating PD-1+ cell counts correlated with significantly shorter patient survival. Our results suggest a prognostic value of the PD-1+ immune cell population in such breast cancer patients. Targeting the PD-1 pathway may be a feasible approach to treating patients with breast cancer.